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Yumi Hayashi et al.
The Journal of biological chemistry, 289(15), 10530-10539 (2014-02-27)
The Lol system comprising five Lol proteins, LolA through LolE, sorts Escherichia coli lipoproteins to outer membranes. The LolCDE complex, an ATP binding cassette transporter in inner membranes, releases outer membrane-specific lipoproteins in an ATP-dependent manner, causing formation of the
Gaetano Santulli et al.
The Journal of clinical investigation, 125(5), 1968-1978 (2015-04-07)
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional
S Ishiwata et al.
The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)
To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The
Adam L Hartman et al.
Neurobiology of disease, 82, 46-53 (2015-06-10)
There are no effective treatments for millions of patients with intractable epilepsy. High-fat ketogenic diets may provide significant clinical benefit but are challenging to implement. Low carbohydrate levels appear to be essential for the ketogenic diet to work, but the
L H Elvers et al.
Journal of inherited metabolic disease, 30(4), 609-609 (2007-06-19)
Neonatal screening for congenital disorders like phenylketonuria (PKU), congenital hypothyroidism (CH) and congenital adrenal hyperplasia (CAH) is generally performed in dried blood spots on filter paper. The analytes of interest for testing for PKU, CH and CAH are phenylalanine, thyrotropin
Initial experience with L-leucine therapy in myelodysplastic syndromes with associated chromosome 5q deletion.
David P Steensma et al.
Blood, 121(21), 4428-4428 (2013-05-25)
Jenna L Jewell et al.
Science (New York, N.Y.), 347(6218), 194-198 (2015-01-09)
The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth. Amino acids stimulate mTORC1 activation at the lysosome in a manner thought to be dependent on the Rag small guanosine triphosphatases (GTPases)
Magda S Santos et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10634-10646 (2013-06-28)
Increasing evidence indicates that individual synaptic vesicle proteins may use different signals, endocytic adaptors, and trafficking pathways for sorting to distinct pools of synaptic vesicles. Here, we report the identification of a unique amino acid motif in the vesicular GABA
Plasma concentrations of phenyllactic acid in phenylketonuria.
P C Clemens et al.
Journal of inherited metabolic disease, 13(2), 227-228 (1990-01-01)
K J Bär et al.
Neurobiology of aging, 24(2), 333-338 (2002-12-25)
Increasing evidence suggests an interaction of oxidative stress and the formation of advanced glycation end products (AGE) in the onset and progression of Alzheimer's disease. We studied levels of pentosidine and N(epsilon)-(carboxymethyl)-lysine (CML) in serum and cerebrospinal fluid (CSF) of
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
Stefanie R Mullins et al.
Biological chemistry, 393(12), 1405-1416 (2013-05-15)
The expression of the cysteine protease cathepsin B is increased in early stages of human breast cancer.To assess the potential role of cathepsin B in premalignant progression of breast epithelial cells, we employed a 3D reconstituted basement membrane overlay culture
Sakshi Arora et al.
Journal of virology, 88(16), 9141-9152 (2014-06-06)
HIV-1 modulates key host cellular pathways for successful replication and pathogenesis through viral proteins. By evaluating the hijacking of the host ubiquitination pathway by HIV-1 at the whole-cell level, we now show major perturbations in the ubiquitinated pool of the
Florian Veillard et al.
Biological chemistry, 393(12), 1471-1476 (2013-05-15)
Bestatin, a specific inhibitor of metalloaminopeptidases,inhibits the growth of Porphyromonas gingivalis. To identify its target enzyme, a library of fluorescent substrates was used but no metalloaminopeptidase activity was found. The aminopeptidase activity of P. gingivalis was bestatin-insensitive and directed exclusively
Dragana Nikitovic et al.
IUBMB life, 60(12), 818-823 (2008-10-25)
Lumican belongs to the family of small leucine-rich repeat proteoglycans. Recent studies have shown that lumican participates in the maintenance of tissue homeostasis and modulates cellular functions including cell proliferation, migration, and differentiation. The expression of lumican has been correlated
Anders Boysen et al.
Journal of microbiological methods, 116, 66-79 (2015-07-06)
Comparative studies of pathogenic bacteria and their non-pathogenic counterparts has led to the discovery of important virulence factors thereby generating insight into mechanisms of pathogenesis. Protein-based antigens for vaccine development are primarily selected among unique virulence-related factors produced by the
Michèle Balage et al.
Current opinion in clinical nutrition and metabolic care, 13(3), 265-270 (2010-01-30)
Leucine does not only serve as a substrate for protein synthesis but is also recognized as a potent signal nutrient that regulates protein metabolism. Accordingly, leucine supplementation has been suggested to develop muscle mass or prevent protein loss in several
A Mero
Sports medicine (Auckland, N.Z.), 27(6), 347-358 (1999-07-27)
Leucine, isoleucine and valine, the branched-chain amino acids (BCAA), make up about one-third of muscle protein. Of these, leucine has been the most thoroughly investigated because its oxidation rate is higher than that of isoleucine or valine. Leucine also stimulates
Iris Thondorf et al.
Bioorganic & medicinal chemistry, 19(21), 6409-6418 (2011-10-01)
The proton-coupled amino acid transporter hPAT1 has recently gained much interest due to its ability to transport small drugs thereby allowing their oral administration. A three-dimensional quantitative structure-activity relationship (3D QSAR) study has been performed on its natural and synthetic
T Yoshimasa et al.
The Journal of clinical investigation, 69(3), 643-650 (1982-03-01)
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with
J K Nicholson et al.
The Biochemical journal, 217(2), 365-375 (1984-01-15)
Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of
Gabriel Oluga Aboge et al.
The Journal of parasitology, 101(5), 536-541 (2015-06-10)
The M17 leucine aminopeptidase (M17LAP) enzymes of the other apicomplexan parasites have been characterized and shown to be inhibited by bestatin. Though Babesia bovis also belongs to the apicomplexan group, it is not known whether its M17LAP could display similar
Xiangbing Mao et al.
PloS one, 10(9), e0137380-e0137380 (2015-09-04)
The present study was mainly conducted to determine whether dietary leucine supplementation could attenuate the decrease of the mucin production in the jejunal mucosa of weaned pigs infected by porcine rotavirus (PRV). A total of 24 crossbred barrows weaned at
Anna Walter et al.
Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)
Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).
Heidi Turkia et al.
Talanta, 131, 366-371 (2014-10-05)
The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino
Y Yang et al.
Journal of dental research, 92(6), 500-506 (2013-04-30)
Hypodontia, a tooth developmental disease, can affect chewing and pronunciation. Mutations in the ectodysplasin-A (EDA) gene can lead to both X-linked hypohidrotic ectodermal dysplasia (XLHED) and non-syndromic hypodontia (NSH). However, the mechanism by which these 2 related but different disorders
Takashi Abe et al.
Journal of neuroscience research, 70(3), 447-450 (2002-10-23)
To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and
Molecular profiling for druggable genetic abnormalities in carcinoma of unknown primary.
Daniel S-W Tan et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(14), e237-e239 (2013-04-03)
Henry J Russell et al.
The FEBS journal, 280(23), 6070-6082 (2013-09-17)
The ability of hemoproteins to discriminate between diatomic molecules, and the subsequent affinity for their chosen ligand, is fundamental to the existence of life. These processes are often controlled by precise structural arrangements in proteins, with heme pocket residues driving
Elin Hadler-Olsen et al.
Journal of cellular physiology, 230(1), 160-169 (2014-06-07)
Matrix metalloproteinase 2 (MMP-2) is a proteolytic enzyme implicated in motility, differentiation, and regeneration of skeletal muscle fibers through processing of extracellular substrates. Although MMP-2 has been found to be localized intracellularly in cardiomyocytes where the enzyme is thought to
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