W3500

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Influence of copper content on the electrocatalytic activity toward methanol oxidation of Co(χ)Cu(y) alloy nanoparticles-decorated CNFs.

Zafar Khan Ghouri et al.

Scientific reports, 5, 16695-16695 (2015-11-17)

In this study, CoCu alloy nanoparticles-incorporated carbon nanofibers are introduced as effective non precious electrocatalyst for methanol oxidation in alkaline medium. The introduced electrocatalyst has been synthesized by simple and effective process; electrospinning. Typically, calcination, in nitrogen atmosphere, of electrospun

Cytoprotective effects of berry anthocyanins against induced oxidative stress and inflammation in primary human diabetic aortic endothelial cells.

Anahita Aboonabi et al.

Chemico-biological interactions, 317, 108940-108940 (2020-01-15)

Type 2 diabetes is associated with oxidative stress and low-grade inflammation resulting in endothelial dysfunction (ED). This study determined to explore the protective effects of berry-derived anthocyanins (AC) with potent antioxidant and anti-inflammatory activities in human diabetic endothelial cells upon

Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells.

Astrid Petermann et al.

Journal of neuro-oncology, 122(3), 451-459 (2015-02-13)

Brain-invasive growth of a subset of meningiomas is associated with less favorable prognosis. The molecular mechanisms causing invasiveness are only partially understood, however, the expression of matrix metalloproteinases (MMPs) has been identified as a contributing factor. We have previously found

Phase II metabolism in human skin: skin explants show full coverage for glucuronidation, sulfation, N-acetylation, catechol methylation, and glutathione conjugation.

Nenad Manevski et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(1), 126-139 (2014-10-24)

Although skin is the largest organ of the human body, cutaneous drug metabolism is often overlooked, and existing experimental models are insufficiently validated. This proof-of-concept study investigated phase II biotransformation of 11 test substrates in fresh full-thickness human skin explants

Effect of salts on the solubility of ionic liquids in water: experimental and electrolyte Perturbed-Chain Statistical Associating Fluid Theory.

Catarina M S S Neves et al.

Physical chemistry chemical physics : PCCP, 17(47), 32044-32052 (2015-11-18)

Due to scarce available experimental data, as well as due to the absence of predictive models, the influence of salts on the solubility of ionic liquids (ILs) in water is still poorly understood. To this end, this work addresses the

Amelioration of the Fitness Costs of Antibiotic Resistance Due To Reduced Outer Membrane Permeability by Upregulation of Alternative Porins.

Michael Knopp et al.

Molecular biology and evolution, 32(12), 3252-3263 (2015-09-12)

The fitness cost of antibiotic resistance is a key parameter in determining the evolutionary success of resistant bacteria. Studies of the effect of antibiotic resistance on bacterial fitness are heavily biased toward target alterations. Here we investigated how the costs

Refluxing synthesis, photoluminescence and binding ability to deoxyribonucleic acid of water-soluble rare earth ion-doped LaF3 nanoparticles.

Zhenling Wang et al.

Journal of nanoscience and nanotechnology, 14(6), 4506-4512 (2014-04-18)

Water-soluble rare earth ion (Ce3+, Tb3+)-doped LaF3 nanoparticles with the ability to bind to deoxyribonucleic acid (DNA) were prepared by the refluxing method in a glycerol/water mixture and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), photoluminescence (PL) spectra

Influence of E. coli-induced prostatic inflammation on expression of androgen-responsive genes and transforming growth factor beta 1 cascade genes in rats.

Yasuhito Funahashi et al.

The Prostate, 75(4), 381-389 (2014-12-03)

Prostatic inflammation is reportedly associated with the development of prostatic hyperplasia. We investigated the effects of prostatic inflammation on expression levels of androgen-responsive genes and growth factors in the rat prostate. Prostatic inflammation was induced by Escherichia coli (strain 1677)

Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.

Susanne Herbst et al.

EMBO molecular medicine, 7(3), 240-258 (2015-02-01)

Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of

Swift adsorptive removal of Congo red from aqueous solution by K1.33Mn8O16 nanowires.

Junshu Wu et al.

Journal of nanoscience and nanotechnology, 13(8), 5452-5460 (2013-07-26)

A swift and efficient approach to converting organic dye effluents into fresh water could be of substantial benefit. In this study, we presented facile hydrothermal synthesis of K1.33Mn8O16 nanowires in ammonium fluoride (NH4F) aqueous solution. The crystallization process of K1.33Mn8O16

Loss of loop adenines alters human telomere d[AG3(TTAG3)3] quadruplex folding.

Martin Babinský et al.

Nucleic acids research, 42(22), 14031-14041 (2014-11-28)

Abasic (AP) lesions are the most frequent type of damages occurring in cellular DNA. Here we describe the conformational effects of AP sites substituted for 2'-deoxyadenosine in the first (ap7), second (ap13) or third (ap19) loop of the quadruplex formed

Enchytraeid Reproduction Test(PLUS): hatching, growth and full life cycle test--an optional multi-endpoint test with Enchytraeus crypticus.

Rita C Bicho et al.

Ecotoxicology (London, England), 24(5), 1053-1063 (2015-03-17)

Soil ecotoxicity standard tests for invertebrates are usually limited to the assessment of endpoints like survival and reproduction. Adverse effects may occur at other developmental stages, e.g. embryo development, hatching or growth. The species Enchytraeus crypticus is a model organism

The host plant metabolite glucose is the precursor of diffusible signal factor (DSF) family signals in Xanthomonas campestris.

Yinyue Deng et al.

Applied and environmental microbiology, 81(8), 2861-2868 (2015-02-15)

Plant pathogen Xanthomonas campestris pv. campestris produces cis-11-methyl-2-dodecenoic acid (diffusible signal factor [DSF]) as a cell-cell communication signal to regulate biofilm dispersal and virulence factor production. Previous studies have demonstrated that DSF biosynthesis is dependent on the presence of RpfF

A new phenolic glycoside from Spiraea prunifolia var. simpliciflora twigs.

Sung Wan Jang et al.

Archives of pharmacal research, 38(11), 1943-1951 (2015-05-01)

The phytochemical investigation of the methanol extract from the twigs of Spiraea prunifolia var. simpliciflora (Rosaceae) using column chromatography led to the isolation of a new phenol glycoside, 1-O-(E)-caffeoyl-2-O-p-(E)-coumaroyl-β-D-glucopyranose (1), together with 16 known phenolic compounds (2-17). The structure of

B lymphocytes regulate airway granulocytic inflammation and cytokine production in a murine model of fungal allergic asthma.

Sumit Ghosh et al.

Cellular & molecular immunology, 12(2), 202-212 (2014-11-05)

Sensitization to fungi often leads to a severe form of asthma that is particularly difficult to manage clinically, resulting in increased morbidity and hospitalizations in these patients. Although B lymphocytes might exacerbate asthma symptoms through the production of IgE, these

Behavioral pattern of physicochemical constituents of the postharvest mango (Mangifera indica L.) influenced by storage stimuli.

Md Khairul Islam

Pakistan journal of biological sciences : PJBS, 16(24), 1985-1990 (2014-02-13)

An investigation was carried at the laboratory of the Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh during the period from May, 2010 to September, 2011 to study the behavioral pattern of some physicochemical constituents of the mango

PAH toxicity at aqueous solubility in the fish embryo test with Danio rerio using passive dosing.

Thomas-Benjamin Seiler et al.

Chemosphere, 112, 77-84 (2014-07-23)

As part of the risk assessment process within REACh, prior to manufacturing and distribution of chemical substances their (eco)toxicological impacts have to be investigated. The fish embryo toxicity test (FET) with the zebrafish Danio rerio has gained a high significance

Germline mutation of CBL is associated with moyamoya disease in a child with juvenile myelomonocytic leukemia and Noonan syndrome-like disorder.

Nobuyuki Hyakuna et al.

Pediatric blood & cancer, 62(3), 542-544 (2014-10-07)

Germline mutations in CBL have been identified in patients with Noonan syndrome-like phenotypes, while juvenile myelomonocytic leukemia (JMML) harbors duplication of a germline CBL, resulting in acquired isodisomy. The association between moyamoya disease and Noonan syndrome carrying a PTPN11 mutation

Future species composition will affect forest water use after loss of eastern hemlock from southern Appalachian forests.

Steven Brantley et al.

Ecological applications : a publication of the Ecological Society of America, 23(4), 777-790 (2013-07-20)

Infestation of eastern hemlock (Tsuga canadensis (L.) Carr.) with hemlock woolly adelgid (HWA, Adelges tsugae) has caused widespread mortality of this key canopy species throughout much of the southern Appalachian Mountains in the past decade. Because eastern hemlock is heavily

High-content assay for measuring intracellular growth of Leishmania in human macrophages.

Michael J Dagley et al.

Assay and drug development technologies, 13(7), 389-401 (2015-08-08)

Leishmania species are sandfly-transmitted protozoan parasites that cause a spectrum of diseases, ranging from localized skin lesions to fatal visceral disease, in more than 12 million people worldwide. These parasites primarily target macrophages in their mammalian hosts and proliferate as

Fate of phosphorus in diluted urine with tap water.

Xiaoning Liu et al.

Chemosphere, 113, 146-150 (2014-07-30)

P loss during the fresh urine storage process is inevitable because of the presence of Ca and Mg. Dilution is one of the most important parameters influencing urine composition and subsequent P recovery. This study aimed to investigate the fate

Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity.

U Taschler et al.

British journal of pharmacology, 172(17), 4419-4429 (2015-06-16)

Monoglyceride lipase (MGL) degrades 2-arachidonoyl glycerol (2-AG), an endogenous agonist of cannabinoid receptors (CB1/2 ). Because the CB1 receptor is involved in the control of gut function, we investigated the effects of pharmacological inhibition and genetic deletion of MGL on

Anharmonicities and coherent vibrational dynamics of phosphate ions in bulk H2O.

Rene Costard et al.

Physical chemistry chemical physics : PCCP, 17(44), 29906-29917 (2015-10-22)

Phosphates feature prominently in the energetics of metabolism and are important solvation sites of DNA and phospholipids. Here we investigate the ion H2PO4(-) in aqueous solution combining 2D IR spectroscopy of phosphate stretching vibrations in the range from 900-1300 cm(-1)

Assays of fibrin network properties altered by VKAs in atrial fibrillation - importance of using an appropriate coagulation trigger.

Michal Ząbczyk et al.

Thrombosis and haemostasis, 113(4), 851-861 (2014-12-19)

Atrial fibrillation (AF) is a prothrombotic condition, involving increased thrombin generation and fibrinogen concentrations. Vitamin K antagonists (VKAs) prevent arterial thromboembolism if optimal anticoagulation is achieved by individualised drug doses, assessed by determining the Prothrombin time-related International Normalized Ratio (Pt-INR).

Comparative proteomic analysis of biofilm and planktonic cells of Lactobacillus plantarum DB200.

Maria De Angelis et al.

Proteomics, 15(13), 2244-2257 (2015-03-03)

This study investigated the relative abundance of extracellular and cell wall associated proteins (exoproteome), cytoplasmic proteins (proteome), and related phenotypic traits of Lactobacillus plantarum grown under planktonic and biofilm conditions. Lactobacillus plantarum DB200 was preliminarily selected due to its ability

Bioconversion of D-glucose to D-psicose with immobilized D-xylose isomerase and D-psicose 3-epimerase on Saccharomyces cerevisiae spores.

Zijie Li et al.

Journal of industrial microbiology & biotechnology, 42(8), 1117-1128 (2015-06-13)

Saccharomyces cerevisiae spores are dormant cells, which can tolerate various types of environmental stress. In our previous work, we successfully developed biological and chemical methods for enzyme immobilization based on the structures of S. cerevisiae spore wall. In this study

Electrochemical immunosensor based on bismuth nanocomposite film and cadmium ions functionalized titanium phosphates for the detection of anthrax protective antigen toxin.

Mukesh K Sharma et al.

Biosensors & bioelectronics, 74, 299-304 (2015-07-08)

Bacillus anthracis is a bioterrorism agent classified by the Centers for Disease Control and Prevention (CDC). Herein, a novel electrochemical immunosensor for the sensitive, specific and easy detection of anthrax protective antigen (PA) toxin in picogram concentration was developed. The

Water channel structures analysed by electron crystallography.

Kazutoshi Tani et al.

Biochimica et biophysica acta, 1840(5), 1605-1613 (2013-10-15)

The mechanisms underlying water transport through aquaporin (AQP) have been debated for two decades. The water permeation phenomenon of AQP seems inexplicable because the Grotthuss mechanism does not allow for simultaneous fast water permeability and inhibition of proton transfer through

Nanotubular structured Si-based multicomponent anodes for high-performance lithium-ion batteries with controllable pore size via coaxial electro-spinning.

Jaegeon Ryu et al.

Nanoscale, 7(14), 6126-6135 (2015-03-17)

We demonstrate a simple but straightforward process for the synthesis of nanotube-type Si-based multicomponents by combining a coaxial electrospinning technique and subsequent metallothermic reduction reaction. Si-based multicomponent anodes consisting of Si, alumina and titanium silicide show several advantages for high-performance

Contrasting patterns of allochthony among three major groups of crustacean zooplankton in boreal and temperate lakes.

Martin Berggren et al.

Ecology, 95(7), 1947-1959 (2014-08-29)

The importance of terrestrial-derived organic matter for lake zooplankton communities remains debated, partly because little is known about the basic pathways by which allochthonous carbon is transferred to zooplankton, and whether these vary among the major taxonomic and functional groups.

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