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Dan Wang et al.
BMC cancer, 14, 591-591 (2014-08-17)
The cytokine TRAIL (tumor necrotic factor-related apoptosis-inducing ligand) selectively induces apoptosis in cancer cells, but cancer stem cells (CSCs) that contribute to cancer-recurrence are frequently TRAIL-resistant. Here we examined hitherto unknown effects of the dietary anti-carcinogenic compound phenethyl isothiocyanate (PEITC)
Breeze E Cavell et al.
Journal of natural products, 75(6), 1051-1057 (2012-05-23)
Phenethyl isothiocyanate (1) is a natural dietary phytochemical with cytostatic, cytotoxic, and antitumor activity. The effects of 1 were investigated on the activity of mTOR, a kinase that enhances the translation of many RNAs encoding proteins critical for cancer cell
Robert W Li et al.
Molecular carcinogenesis, 52(6), 426-437 (2012-02-07)
Temporal growth of tumor xenografts in mice on a control diet was compared to mice supplemented daily with 3 µmol/g of the cancer preventive compound phenethyl isothiocyanate. Phenethyl isothiocyanate decreased the rate of tumor growth. The effects of phenethyl isothiocyanate
Noriyuki Miyoshi et al.
Analytical biochemistry, 429(2), 124-131 (2012-07-28)
In this study, we have developed a novel method to identify isothiocyanate (ITC)-targeted molecules using two well-studied ITCs: benzyl ITC (BITC) and phenethyl ITC (PEITC). The principle of this method is based on identifying a pattern of differences between BITC
Reduced susceptibility of Brassica napus to Pratylenchus neglectus in plants with elevated root levels of 2-phenylethyl glucosinolate.
Potter MJ, et al.
Journal of Nematology, 31(3), 291-291 (1999)
Long G Wang et al.
International journal of oncology, 37(3), 533-539 (2010-07-29)
Prostate cancer is one of the most commonly diagnosed cancers in men. The number of affected men is expected to rapidly increase as the population of males over the age of 50 grows worldwide. For patients who are not cured
Jing Xiao et al.
The Prostate, 72(14), 1514-1522 (2012-02-09)
Aberrant expressions of microRNAs, including upregulation of miR-141, are closely associated with the tumorigenesis of prostate cancer (PCa). The orphan receptor small heterodimer partner (Shp) is a co-repressor to androgen receptor (AR) and represses AR-regulated transcriptional activity. Here, we investigated
Sinara Mônica Vitalino de Almeida et al.
International journal of molecular sciences, 16(6), 13023-13042 (2015-06-13)
In this work, the acridine nucleus was used as a lead-compound for structural modification by adding different substituted thiosemicarbazide moieties. Eight new (Z)-2-(acridin-9-ylmethylene)-N-phenylhydrazinecarbothioamide derivatives (3a-h) were synthesized, their antiproliferative activities were evaluated, and DNA binding properties were performed with calf
Atsunori Yafune et al.
Toxicology letters, 219(3), 203-210 (2013-03-29)
We have previously reported that hepatocarcinogens increase liver cells expressing p21(Cip1), a G1 checkpoint protein and M phase proteins after 28-day treatment in rats. This study aimed to identify early prediction markers of carcinogens available in many target organs after
Anabela Borges et al.
Journal of food science and technology, 52(8), 4737-4748 (2015-08-06)
Plants contain numerous components that are important sources of new bioactive molecules with antimicrobial properties. Isothiocyanates (ITCs) are plant secondary metabolites found in cruciferous vegetables that are arising as promising antimicrobial agents in food industry. The aim of this study
A E Elaine van Ommen Kloeke et al.
Chemosphere, 89(9), 1084-1090 (2012-06-16)
Glucosinolates are compounds produced by commercial crops which can hydrolyse in a range of natural toxins that may exert detrimental effects on beneficial soil organisms. This study examined the effects of 2-phenylethyl isothiocyanate and 3-phenylpropionitrile on the survival and growth
Zhen Xiao et al.
The Journal of nutrition, 142(7), 1377S-1381S (2012-06-01)
Although isothiocyanates (ITC), which are found in cruciferous vegetables, have been shown to inhibit carcinogenesis in animal models and induce apoptosis and cell cycle arrest in tumor cells, the biochemical mechanisms of cell growth inhibition by these compounds are not
I S Chen et al.
Human & experimental toxicology, 31(12), 1251-1261 (2012-06-02)
The effect of the natural compound phenethyl isothiocyanate (PEITC) on cytosolic Ca(2+) concentrations ([Ca(2+)](i)) and viability in MDCK renal cells is unknown. This study explored whether PEITC changed [Ca(2+)](i) in MDCK cells using the Ca(2+)-sensitive fluorescent dye fura-2. PEITC at
Urvi Aras et al.
Biopharmaceutics & drug disposition, 34(2), 98-106 (2012-11-10)
The effect of phenethyl isothiocyanate (PEITC), a component of cruciferous vegetables, on the initiation and progression of cancer was investigated in a chemically induced estrogen-dependent breast cancer model. Breast cancer was induced in female Sprague Dawley rats (8 weeks old)
In vitro inhibition of soil microorganisms by 2?phenylethyl isothiocyanate.
Smith BJ & Kirkegaard JA
Plant Pathology, 51(5), 585-593 (2002)
Hiroki Ishibashi et al.
The journal of medical investigation : JMI, 59(3-4), 246-252 (2012-10-06)
Bile and pancreatic juice contain a number of parameters for cancer chemoprevention. Indole-3-carbinol (I3C) and phenethyl isothiocyanate (PEITC), which are hydrolytic products of brassica plants, have been established to be anti-cancer agents. Here, we developed a method for the continuous
Jianzhong Zhu et al.
Journal of immunology (Baltimore, Md. : 1950), 190(8), 4400-4407 (2013-03-20)
Naturally occurring isothiocyanates (ITCs) from cruciferous vegetables are widely studied for their cancer chemopreventive effects. In this study, we investigated the effects of ITCs on TLR signaling, and found that the two most promising ITCs, phenethyl ITCs (PEITC) and D,L-sulforaphane
Antibacterial activity and synergistic effect between watercress extracts, 2?phenylethyl isothiocyanate and antibiotics against 11 isolates of Escherichia coli from clinical and animal source.
Freitas E, et al.
Letters in Applied Microbiology, 57(4), 266-273 (2013)
Sivakumar Loganathan et al.
PloS one, 7(8), e43577-e43577 (2012-09-07)
Ovarian cancer is the leading cause of cancer related deaths in women. Genetic alterations including overexpression of EGFR play a crucial role in ovarian carcinogenesis. Here we evaluated the effect of phenethyl isothiocyanate (PEITC) in ovarian tumor cells in vitro
L D Huong et al.
Oral diseases, 18(5), 513-519 (2012-02-09)
β-Phenylethyl isothiocyanate (PEITC) has been demonstrated to fight many types of cancers through various molecular pathways. In this study, we focused on its effect on the induction of apoptosis to inhibit cell growth and molecular mechanism in oral cancer. 3-(4,5-dimethylthiazol-2-yl)-5-(2,4-disulfophenyl)-2-(4
Ka Lung Cheung et al.
The AAPS journal, 12(1), 87-97 (2009-12-17)
Development of cancer is a long-term and multistep process which comprises initiation, progression, and promotion stages of carcinogenesis. Conceivably, it can be targeted and interrupted along these different stages. In this context, many naturally occurring dietary compounds from our daily
Joel D A Tyndall et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 68(Pt 9), 999-1002 (2012-09-06)
Macrophage migration inhibitory factor is irreversibly inhibited via covalent modification by phenethyl isothiocyanate, a naturally occurring compound with anti-inflammatory and anticancer properties. The structure of the modified protein obtained from X-ray diffraction data to 1.64 Å resolution is presented. The
Sarah Weiler et al.
Molecular cancer, 14, 30-30 (2015-02-04)
Members of the inhibitor of DNA-binding (ID) family of helix-loop-helix proteins have been causally implicated in the pathogenesis of several types of B-cell lineage malignancy, either on the basis of mutation or by altered expression. B-cell chronic lymphocytic leukemia encompasses
Parul Gupta et al.
BMC medicine, 10, 80-80 (2012-07-25)
HER2 is an oncogene, expression of which leads to poor prognosis in 30% of breast cancer patients. Although trastuzumab is apparently an effective therapy against HER2-positive tumors, its systemic toxicity and resistance in the majority of patients restricts its applicability.
Ahmad F Abdull Razis et al.
Molecular nutrition & food research, 56(3), 425-434 (2011-12-17)
The aryl hydrocarbon (Ah) receptor is a ligand-activated transcription factor that is activated by many carcinogens, and its target gene products play a major role in tumour development, so that antagonists of the Ah receptor represent potential chemopreventive agents. Experimental
Shivendra V Singh et al.
Journal of the National Cancer Institute, 104(16), 1228-1239 (2012-08-04)
Phenethyl isothiocyanate (PEITC) is a natural plant compound with chemopreventative potential against some cancers and the ability to induce apoptosis in breast cancer cells. Female mouse mammary tumor virus-neu mice were fed a control AIN-76A diet (n = 35) or
Molecular and life-history effects of a natural toxin on herbivorous and non-target soil arthropods.
A E Elaine van Ommen Kloeke et al.
Ecotoxicology (London, England), 21(4), 1084-1093 (2012-02-09)
Natural toxins, such as isothiocyanate (ITC), are harmful secondary metabolites produced by plants. Many natural toxins occur in commercial crops, yet their possible negative repercussions on especially non-target soil organisms are largely unknown. This study examined life-history and gene transcriptional
L Truitt et al.
Oncogenesis, 3, e122-e122 (2014-10-21)
Chronic myelogenous leukemia (CML) is maintained by a minor population of leukemic stem cells (LSCs) that exhibit innate resistance to tyrosine kinase inhibitors (TKIs) targeting BCR-ABL. Innate resistance can be induced by secreted bone marrow stromal cytokines and growth factors
Andrzej Pawlik et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(10), 3577-3594 (2012-08-01)
Isothiocyanates are known for their anticarcinogenic and antitumor potential, however, the exact mechanism of their action has not been fully elucidated. The present study was designed to investigate and compare the effects of phenethyl isothiocyanate on cell morphology, the cytoskeleton
Sharifah S Syed Alwi et al.
Cell stress & chaperones, 17(5), 529-538 (2012-02-22)
Phenethyl isothiocyanate (PEITC) is a naturally occurring electrophile which depletes intracellular glutathione (GSH) levels and triggers accumulation of reactive oxygen species (ROS). PEITC is of considerable interest as a potential chemopreventive/chemotherapeutic agent, and in this work, we have investigated the
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