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Maria Luiza Zeraik et al.
PloS one, 9(10), e110277-e110277 (2014-10-24)
Pro-oxidant effects of phenolic compounds are usually correlated to the one-electron redox potential of the phenoxyl radicals. Here we demonstrated that, besides their oxidizability, hydrophobicity can also be a decisive factor. We found that esterification of protocatechuic acid (P0) provoked
Volatile composition of aged wine in used barrels of French oak and of American oak.
Cerdan TG, et al.
Food Research International, 35(7), 603-610 (2002)
Peter N Mittwede et al.
American journal of physiology. Renal physiology, 308(2), F157-F163 (2014-11-28)
After trauma, obese patients have an increased risk of developing acute kidney injury (AKI). We have demonstrated that obese Zucker (OZ) rats, but not lean Zucker (LZ) rats, develop AKI 24 h after orthopedic trauma. ROS have been implicated in
Sivareddy Kotla et al.
Free radical biology & medicine, 76, 147-162 (2014-08-26)
15(S)-Hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1/2 (15-LO1/2) metabolite of arachidonic acid (AA), induces CD36 expression through xanthine oxidase and NADPH oxidase-dependent ROS production and Syk and Pyk2-dependent STAT1 activation. In line with these observations, 15(S)-HETE also induced foam cell
R P Mason et al.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 66(1), 65-72 (2015-02-27)
Clinical trials have shown that atorvastatin benefits patients with diabetes even with normal baseline LDL levels. We hypothesized that atorvastatin improves endothelial cell (EC) function and reduces inflammation in hypertensive rats with diabetes. Non-diabetic and streptozotocin-induced type 2 diabetic male
Yibo Zhuang et al.
American journal of physiology. Renal physiology, 307(4), F396-F406 (2014-02-28)
Hyperuricemia is associated with kidney complications including glomerulosclerosis and mesangial cell (MC) proliferation by poorly understood mechanisms. The present study investigated the underlying mechanisms that mediate uric acid (UA)-induced MC proliferation. A rat MC line, HBZY-1, was treated with various
Hardik Chandasana et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 985, 180-188 (2015-02-16)
Apocynin is a major active constituent of Picrorhiza kurroa that exhibits potent anti-inflammatory activity by inhibiting superoxide-generating NADPH oxidase enzyme. To elucidate detailed pharmacokinetic profile of apocynin, high-performance liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed in
Matthew R DiStasi et al.
American journal of physiology. Heart and circulatory physiology, 309(7), H1207-H1217 (2015-08-25)
The present study was undertaken to establish the role of NADPH oxidase (Nox) in impaired vascular compensation to arterial occlusion that occurs in the presence of risk factors associated with oxidative stress. Diet-induced obese (DIO) mice characterized by multiple comorbidities
Vasyl Holobotovskyy et al.
Science translational medicine, 7(290), 290ra88-290ra88 (2015-06-05)
Preeclampsia is a systemic vascular disorder of pregnancy and is associated with increased sensitivity to angiotensin II (AngII) and hypertension. The cause of preeclampsia remains unknown. We identified the role of regulator of G protein (heterotrimeric guanine nucleotide-binding protein) signaling
Julio Madrigal-Matute et al.
Journal of the American Heart Association, 3(4) (2014-08-07)
Galectin-3 (Gal-3) participates in different mechanisms involved in atherothrombosis, such as inflammation, proliferation, or macrophage chemotaxis. Thus, there have been committed intensive efforts to elucidate the function of Gal-3 in cardiovascular (CV) diseases. The role of Gal-3 as a circulating
Byung Hee Han et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(8), E881-E890 (2015-02-13)
Cerebral amyloid angiopathy (CAA) is characterized by deposition of amyloid β peptide (Aβ) within walls of cerebral arteries and is an important cause of intracerebral hemorrhage, ischemic stroke, and cognitive dysfunction in elderly patients with and without Alzheimer's Disease (AD).
Aurélia Lelli et al.
Glia, 61(9), 1542-1555 (2013-07-10)
The phagocyte NADPH oxidase Nox2 generates superoxide ions implicated in the elimination of microorganisms and the redox control of inflammatory signaling. However, the role of Nox2 in phagocyte functions unrelated to immunity or pathologies is unknown. During development, oriented cell
Ayumu Takeno et al.
Bone, 77, 135-141 (2015-05-03)
Elevated plasma homocysteine (Hcy) level is associated with the risk of osteoporotic fracture. While Hcy increases oxidative stress, AMP-activated protein kinase (AMPK) activation ameliorates it. This study aimed to investigate whether Hcy induces apoptosis of osteocytic MLO-Y4 cells through regulating
Madonna R Peter et al.
Mediators of inflammation, 2014, 767185-767185 (2014-08-13)
Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng (+/-)) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and
Rukhsana Gul et al.
Obesity (Silver Spring, Md.), 23(11), 2251-2259 (2015-09-19)
Resistance to obesity is observed in rodents and humans treated with rapamycin (Rap) or nebivolol (Neb). Because cardiac miR-208a promotes obesity, this study tested whether the modes of actions of Rap and Neb involve inhibition of miR-208a. Mouse cardiomyocyte HL-1
Hiroshi Itoh et al.
Journal of leukocyte biology, 98(1), 107-117 (2015-04-25)
Autophagy occurs in human neutrophils after the phagocytosis of multidrug-resistant bacteria and drug-sensitive strains, including Escherichia coli and Pseudomonas aeruginosa. The present study detected autophagy by immunoblot analysis of LC3B conversion, by confocal scanning microscopic examination of LC3B aggregate formation
Katarzyna Winiarska et al.
Chemico-biological interactions, 218, 12-19 (2014-05-07)
Apocynin (4'-hydroxy-3'-methoxyacetophenone) is the most commonly used NADPH oxidase (Nox) inhibitor. However, its application raises serious controversies, as the compound has been reported to reveal some prooxidative effects. The aim of this study was to elucidate apocynin action on glutathione
Souichi Nakashima et al.
Bioorganic & medicinal chemistry, 18(6), 2337-2345 (2010-03-02)
The methanolic extract from the whole plants of Anastatica hierochuntica, an Egyptian herbal medicine, was found to inhibit melanogenesis in theophylline-stimulated murine B16 melanoma 4A5 cells. Among the constituents isolated, anastatin A, silybin A, isosilybins A and B, eriodictyol, luteolin
Marvin S Medow et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(1), 45-51 (2012-11-10)
Local cutaneous heating causes vasodilation as an initial first peak, a nadir, and increase to plateau. Reactive oxygen species (ROS) modulate the heat plateau in healthy controls. The initial peak, due to C-fiber nociceptor-mediated axon reflexes, is blunted with local
Xiao-Long Hu et al.
Neurochemistry international, 87, 66-76 (2015-06-13)
A major cause of cerebral ischemia is overactivation of the N-methyl-D-aspartate receptors (NMDARs). Therefore, NMDAR antagonists are needed for the treatment of cerebral ischemia. In our research, KuB protected the SH-SY5Y cells against NMDA-induced injury, apoptosis, LDH release and MMP
Xin-Ling Fang et al.
PloS one, 8(1), e53142-e53142 (2013-01-18)
Serotonin (5-HT) is a central inhibitor of food intake in mammals. Thus far, the intracellular mechanisms for the effect of serotonin on appetite regulation remain unclear. It has been recently demonstrated that reactive oxygen species (ROS) in the hypothalamus are
Hiroka Suzuki et al.
American journal of physiology. Cell physiology, 307(4), C384-C394 (2014-06-20)
Transient receptor potential ankyrin 1 (TRPA1) is a Ca(2+)-permeable nonselective cation channel expressed in neuronal and nonneuronal cells and plays an important role in acute and inflammatory pain. Here, we show that an NADPH oxidase (NOX) inhibitor, diphenyleneiodonium (DPI), functions
Luana Chiquetto Paracatu et al.
Evidence-based complementary and alternative medicine : eCAM, 2014, 793629-793629 (2014-09-26)
Numerous anti-inflammatory properties have been attributed to caffeic acid phenethyl ester (CAPE), an active component of propolis. NADPH oxidases are multienzymatic complexes involved in many inflammatory diseases. Here, we studied the importance of the CAPE hydrophobicity on cell-free antioxidant capacity
Joana B Sousa et al.
Neurochemistry international, 80, 7-13 (2014-12-03)
The present study intends to clarify if endothelium dysfunction impairs vascular sympathetic neurotransmission. Electrically-evoked tritium overflow (100 pulses/5 Hz) was evaluated in arteries (intact and denuded) or exhibiting some degree of endothelium dysfunction (spontaneously hypertensive arteries), pre-incubated with [(3)H]-noradrenaline in the
Nina Queisser et al.
Antioxidants & redox signaling, 21(15), 2126-2142 (2014-02-12)
An increased kidney cancer risk was found in hypertensive patients, who frequently exhibit hyperaldosteronism, known to contribute to kidney injury, with oxidative stress playing an important role. The capacity of kidney cells to up-regulate transcription factor nuclear factor-erythroid-2-related factor 2
Chao-Wei Hu et al.
Pflugers Archiv : European journal of physiology, 466(11), 2049-2057 (2014-02-11)
Cardiac T-type Ca(2+) channels are reexpressed in atrial and ventricular myocytes under various pathological conditions such as post-myocardial infarction, hypertrophy, and heart failure, but relatively little is known about the mechanisms. Our previous study found that bone morphogenetic protein-4 (BMP4)
Sushma Reddy Gundala et al.
Toxicology and applied pharmacology, 280(1), 86-96 (2014-07-30)
Dietary phytochemicals are excellent ROS-modulating agents and have been shown to effectively enhance ROS levels beyond toxic threshold in cancer cells to ensure their selective killing while leaving normal cells unscathed. Here we demonstrate that hydroxychavicol (HC), extracted and purified
Rebecca Lim et al.
American journal of obstetrics and gynecology, 212(1), 86-86 (2014-07-22)
Clinical management of preeclampsia has remained unchanged for almost 5 decades. We now understand that maternal endothelial dysfunction likely arises because of placenta-derived vasoactive factors. Activin A is one such antiangiogenic factor that is released by the placenta and that
W K Eddie Ip et al.
Nature communications, 6, 6931-6931 (2015-05-12)
Interstitial osmolality is a key homeostatic variable that varies depending on the tissue microenvironment. Mammalian cells have effective mechanisms to cope with osmotic stress by engaging various adaptation responses. Hyperosmolality due to high dietary salt intake has been linked to
Liang Liang et al.
Molecular endocrinology (Baltimore, Md.), 28(8), 1291-1303 (2014-06-24)
Males develop kidney stones far more frequently than females with a ratio of 2-3:1, suggesting that androgen receptor (AR) signaling might play a key role in the development of nephrolithiasis. Using the cre-loxP system to selectively knock out AR in
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