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X100
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Mohsen Saeedi et al.
Journal of environmental management, 214, 204-214 (2018-03-12)
The effects of soil components such as clay minerals and as humic acids, as well as co-existing metals and polycyclic aromatic hydrocarbons, on desorption and mobility are examined. Three types of artificially blended clay and clay mineral mixtures (pure kaolinite
Weiling Zou et al.
Analytical and bioanalytical chemistry, 413(5), 1429-1440 (2021-01-07)
The sensitive chitosan (CTS) detection methods based on the resonance Rayleigh scattering (RRS) quenching method and fluorescence quenching of Eosin Y were put forward. In the HAC-NaAC buffer solution, Eosin Y interacted with Triton X-100 to generate the binary complex
Samantha T Clark et al.
Colloids and surfaces. B, Biointerfaces, 187, 110609-110609 (2019-12-07)
The effects of lipid charge and head group size on liposome partitioning by detergents is an important consideration for applications such as liposomal drug delivery or proteoliposome formation. Yet, the solubilization of mixed-lipid liposomes, those containing multiple types of lipids
Marta Vignola et al.
Water research, 143, 66-76 (2018-06-26)
Rapid quantification of absolute microbial cell abundances is important for a comprehensive interpretation of microbiome surveys and crucial to support theoretical modelling and the design of engineered systems. In this paper, we propose a protocol specifically optimised for the quantification
Evaluation of different decellularization protocols on the generation of pancreas-derived hydrogels.
Roberto Gaetani et al.
Tissue engineering. Part C, Methods (2018-11-07)
Different approaches have investigated the effects of the different extracellular matrices (ECMs) and 3D culture on islets function, showing encouraging results. Ideally, the proper scaffold should mimic the biochemical composition of the native tissue as it drives numerous signaling pathways
Daniel J Spade et al.
Biology of reproduction, 93(5), 110-110 (2015-09-25)
In utero exposure to some phthalate esters adversely affects the development of the rat seminiferous cord, causing germ cell loss and increasing the number of multinucleated germ cells (MNGs). To understand the timing of MNG formation and determine whether it
Anusha Chidambaram et al.
Investigational new drugs, 35(6), 691-705 (2017-08-05)
Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene expression through their effects on the compact chromatin structure. In clinical studies, several classes of histone deacetylase inhibitors (HDACi) have demonstrated potent anticancer activities with metal complexes.
Fangbiao Zhang et al.
The International journal of artificial organs, 42(9), 500-507 (2019-05-14)
To study the different concentrations of Triton X-100 and nuclease needed to remove cells from the tracheal matrix of rabbits and analyse their biocompatibility and cellular compatibility. Fifty tracheas were harvested from donor New Zealand rabbits. Thirty tracheas were randomly
Lin Gan et al.
Nature cell biology, 21(5), 614-626 (2019-05-01)
Cell growth is controlled by a lysosomal signalling complex containing Rag small GTPases and mammalian target of rapamycin complex 1 (mTORC1) kinase. Here, we carried out a microscopy-based genome-wide human short interfering RNA screen and discovered a lysosome-localized G protein-coupled
Hong-Mei Li et al.
Archives of pharmacal research, 38(6), 1066-1071 (2014-09-07)
Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were
Zhen Huang et al.
Clinica chimica acta; international journal of clinical chemistry, 483, 222-226 (2018-05-08)
In clinical diagnosis of cancer, immunology assay with single tumor marker often lead to a false and missed inspection. A quantitative method with a high degree of accuracy, sensitivity, and effectiveness is required for its diagnosis. We developed a dual-label
Patrick Aouad et al.
Anti-cancer drugs, 28(7), 757-770 (2017-05-05)
Despite recent advances in chemotherapy, aggressive and metastatic breast cancers remain refractory to targeted therapy and the development of novel drugs is urgently needed. Retinoids are crucial regulators of cellular proliferation, differentiation, and cell death, and have shown potent chemotherapeutic
Gabriele Picco et al.
EMBO molecular medicine, 9(3), 293-303 (2017-01-20)
In colorectal cancer (CRC), WNT pathway activation by genetic rearrangements of RSPO3 is emerging as a promising target. However, its low prevalence severely limits availability of preclinical models for in-depth characterization. Using a pipeline designed to suppress stroma-derived signal, we
Magdalena K Baaske et al.
Neurobiology of disease, 146, 105119-105119 (2020-09-30)
Abnormally sustained beta-frequency synchronisation between the motor cortex and subthalamic nucleus (STN) is associated with motor symptoms in Parkinson's disease (PD). It is currently unclear whether STN neurons have a preference for beta-frequency input (12-35 Hz), rather than cortical input at
Yan Nie et al.
Clinical hemorheology and microcirculation, 76(2), 329-340 (2020-09-15)
The formation of spheroids is tightly regulated by intrinsic cell-cell and cell-substrate interactions. The chitosan (CS)-coating was applied to investigate the driven force directed the spheroid formation. The effects of CS on cell functions were studied. Atomic force microscopy was
P Ghosh et al.
Free radical research, 49(4), 453-471 (2015-03-03)
The widely used anti-cancer drug cisplatin imparts various toxic manifestations in the host, with nephrotoxicity being the most severe one. The trace element selenium shows antioxidant activity in both human and animals. The present study was designed to assess the
Tae-Muk Kim et al.
Journal of ethnopharmacology, 253, 112082-112082 (2019-07-17)
Eriobotrya japonica leaves has a very long history of medicinal use as an anti-inflammatory and antitussive agent for bronchial inflammation. The aim of this study was to evaluate the anti-inflammatory activities of Eriobotrya japonica (EJ) leaf water extract in an
Daniel A Berg et al.
Cell, 177(3), 654-668 (2019-04-02)
New neurons arise from quiescent adult neural progenitors throughout life in specific regions of the mammalian brain. Little is known about the embryonic origin and establishment of adult neural progenitors. Here, we show that Hopx+ precursors in the mouse dentate
S Rößler et al.
Scientific reports, 10(1), 118-118 (2020-01-12)
Multiphasic silica/collagen xerogels are biomaterials designed for bone regeneration. Biphasic silica/collagen xerogels (B30) and triphasic xerogels (B30H20 or B30CK20) additionally containing hydroxyapatite or calcite were demonstrated to exhibit several structural levels. On the first level, low fibrillar collagen serves as
Katharina Leitmeyer et al.
BioMed research international, 2015, 925890-925890 (2015-04-29)
Rapamycin is an antifungal agent with immunosuppressive properties. Rapamycin inhibits the mammalian target of rapamycin (mTOR) by blocking the mTOR complex 1 (mTORC1). mTOR is an atypical serine/threonine protein kinase, which controls cell growth, cell proliferation, and cell metabolism. However
Ching-Hui Lin et al.
Lab on a chip, 15(14), 2928-2938 (2015-06-11)
In vitro culture of single cells facilitates biological studies by deconvoluting complications from cell population heterogeneity. However, there is still a lack of simple yet high-throughput methods to perform single cell culture experiments. In this paper, we report the development
Chaoshuai Zhao et al.
Journal of cellular and molecular medicine, 24(20), 12164-12175 (2020-09-13)
Vitiligo is a refractory disfiguring skin disease. However, the aetiology and pathogenesis of vitiligo have not been fully defined. Previous studies have shown that exosomes from normal human keratinocytes improve melanogenesis by up-regulating the expression of melanogenesis-related proteins. Several microRNAs
Junha Park et al.
ACS biomaterials science & engineering, 6(12), 6938-6948 (2020-12-16)
Mesenchymal stem-cell (MSC)-based therapies have been recognized as promising strategies for the treatment of various injuries or diseases because of their unique characteristics, such as self-renewal, differentiation potential, and secretion of various bioactive molecules. However, MSC transplantation often results in
Stephanie B M Miller et al.
The EMBO journal, 34(6), 778-797 (2015-02-13)
Disruption of the functional protein balance in living cells activates protective quality control systems to repair damaged proteins or sequester potentially cytotoxic misfolded proteins into aggregates. The established model based on Saccharomyces cerevisiae indicates that aggregating proteins in the cytosol
Daniel Wells et al.
eLife, 9 (2020-08-04)
During meiosis, homologous chromosomes pair and recombine, enabling balanced segregation and generating genetic diversity. In many vertebrates, double-strand breaks (DSBs) initiate recombination within hotspots where PRDM9 binds, and deposits H3K4me3 and H3K36me3. However, no protein(s) recognising this unique combination of
Jonas Fritze et al.
Stem cells (Dayton, Ohio), 38(9), 1175-1187 (2020-05-30)
Neurogenesis, the production of new neurons from neural stem cells, dramatically decreases during aging concomitantly with increased inflammation both systemically and in the brain. However, the precise role of inflammation and whether local or systemic factors drive the neurogenic decline
Dina G Zayed et al.
Journal of nanobiotechnology, 17(1), 7-7 (2019-01-21)
The rationale of this study is to combine the merits of both albumin nanoparticles and quantum dots (QDs) in improved drug tumor accumulation and strong fluorescence imaging capability into one carrier. However, premature drug release from protein nanoparticles and high
Lanqing Sun et al.
Frontiers in cellular and infection microbiology, 10, 606541-606541 (2021-01-05)
Salmonella are common enteric bacterial pathogens that infect both humans and animals. Intestinal epithelial barrier, formed by a single layer of epithelial cells and apical junctional complex (AJC), plays a crucial role in host defense against enteric pathogens to prevent
Alexey A Tinkov et al.
Biological trace element research, 175(2), 367-374 (2016-06-18)
The primary objective of the current study was to assess the influence of early high-fat feeding on tissue trace element content in young male Wistar rats. Twenty weanling male Wistar rats were divided into two groups fed standard (STD) or
Magdalena Zasada et al.
Pediatric research, 88(3), 391-397 (2020-02-14)
Retinal gene expression pattern is severely altered after exposition to hyperoxia in mice with oxygen-induced retinopathy (OIR), a common model of retinopathy of prematurity. Gene ontology and signaling pathway analyses may add new insights into a better understanding of the
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