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Maria Piisilä et al.
BMC plant biology, 15, 53-53 (2015-04-08)
The Arabidopsis thaliana F-box protein MORE AXILLARY GROWTH2 (MAX2) has previously been characterized for its role in plant development. MAX2 appears essential for the perception of the newly characterized phytohormone strigolactone, a negative regulator of polar auxin transport in Arabidopsis.
Xanthine oxidase: biochemistry, distribution and physiology.
D A Parks et al.
Acta physiologica Scandinavica. Supplementum, 548, 87-99 (1986-01-01)
Hlengiwe Pretty Madlala et al.
PloS one, 10(6), e0128192-e0128192 (2015-06-06)
The triterpene oleanolic acid (OA) is known to possess antihypertensive actions. In the present study we to compared the effects of the triterpene on mean arterial blood pressure (MAP) and kidney function following acute administration in normotensive animals with those
Guyue Cheng et al.
PloS one, 10(8), e0136450-e0136450 (2015-08-22)
Quinoxaline 1,4-di-N-oxides (QdNOs) are widely known as potent antibacterial agents, but their antibacterial mechanisms are incompletely understood. In this study, the transcriptomic and proteomic profiles of Escherichia coli exposed to QdNOs were integratively investigated, and the results demonstrated that QdNOs
Lei Zhang et al.
The Analyst, 137(13), 3126-3131 (2012-05-25)
A novel gold nanoparticles-single-walled carbon nanohorn (GNPs-SWCNH) hybrid was synthesized for the construction of an amperometric biosensing platform. The GNPs-SWCNH hybrid was stable in aqueous solution for at least two weeks, and was characterized with scanning electron microscopy, transmission electron
Yasuhiro Ishihara et al.
The Journal of biological chemistry, 290(37), 22805-22817 (2015-08-02)
Microglia are activated quickly in response to external pathogens or cell debris and clear these substances via the inflammatory response. However, excessive activation of microglia can be harmful to host cells due to the increased production of reactive oxygen species
L Narici et al.
Free radical biology & medicine, 53(3), 482-487 (2012-05-29)
Rod outer segments of photoreceptors are characterized by rhodopsin, a membrane protein surrounded by phospholipids containing a very high concentration of polyunsaturated fatty acids. These fatty acids can propagate free radicals, initiated by peroxidation, whose recombination is eventually associated with
Alexander C Roy et al.
Bioorganic & medicinal chemistry letters, 20(1), 141-144 (2009-12-17)
CTP synthase (CTPS) catalyzes the conversion of UTP to CTP and is a recognized target for the development of anticancer, antiviral, and antiprotozoal agents. Xanthine and related compounds inhibit CTPS activity (IC(50)=0.16-0.58mM). The presence of an 8-oxo function (i.e., uric
Sang Il Gum et al.
Biological & pharmaceutical bulletin, 37(10), 1626-1632 (2014-08-19)
Recently, Banhabackchulchunmatang (HMC05) has been implicated as a preventive and/or therapeutic candidate for cardiovascular diseases due to its inhibition of atherosclerosis lesions and its reduction of neointima formation. Knowledge of the mechanism of HMC05 in smooth muscle cells (SMC) is
Anna Zhachkina Michelson et al.
Journal of the American Chemical Society, 134(23), 9622-9633 (2012-05-05)
3-Methyladenine DNA glycosylase II (AlkA) is an enzyme that cleaves a wide range of damaged bases from DNA. The gas-phase thermochemical properties (tautomerism, acidity, and proton affinity) have been measured and calculated for a series of AlkA purine substrates (7-methyladenine
S K Hasan et al.
Human & experimental toxicology, 34(6), 628-641 (2014-10-30)
2-Acetylaminofluorene (2-AAF) is a known hepatic carcinogen which leads to tumour formation in rodents. 18-β Glycyrrhetinic acid (18β-GA) derived from liquorice plant has various pharmacological properties such as anti-ulcer, anti-inflammatory, antiviral, hepatoprotective and antioxidant. This study is designed to elucidate
Yangping Liu et al.
Free radical biology & medicine, 53(11), 2081-2091 (2012-09-25)
Superoxide (O(2)(•-)) plays crucial roles in normal physiology and disease; however, its measurement remains challenging because of the limited sensitivity and/or specificity of prior detection methods. We demonstrate that a tetrathiatriarylmethyl (TAM) radical with a single aromatic hydrogen (CT02-H) can
Lisa L Drewry et al.
mBio, 6(3), e00557-e00557 (2015-06-18)
Apicomplexan parasites actively invade host cells using a mechanism predicted to be powered by a parasite actin-dependent myosin motor. In the model apicomplexan Toxoplasma gondii, inducible knockout of the actin gene, ACT1, was recently demonstrated to limit but not completely
Jorge I Mardones et al.
Harmful algae, 98, 101892-101892 (2020-11-02)
Karenia selliformis is a bloom-forming toxic dinoflagellate known for production of gymnodimines (GYMs) and causing mass mortalities of marine fauna. Blooms have been reported from coastal waters of New Zealand, Mexico, Tunisia, Kuwait, Iran, China and Chile. Based on molecular
Xiaohong Pan et al.
Analytical chemistry, 87(14), 7092-7097 (2015-06-19)
Vitamin C (ascorbic acid; AA) is a well-known reducing agent and has been evaluated for its antitumor activity. However, the mechanism for its antitumor action remains unclear. Tracking the metabolism of AA may help to elucidate its antitumor mechanism. In
Yuki Ishii et al.
Archives of dermatological research, 306(5), 467-473 (2014-01-15)
Recent studies have shown that some probiotics affect not only the gut but also the skin. However, the effects of probiotics on ultraviolet (UV)-induced skin damage are poorly understood. In this study, we aim to examine whether oral administration of
Tara R deBoer et al.
Journal of inorganic biochemistry, 138, 24-30 (2014-05-27)
Peroxynitrite has been shown to play a critical role in inflammation and affords 3-nitrotyrosine as the hallmark product. The reported methods of generating this reactive nitrogen species in situ often fails to provide a high and steady flux of peroxynitrite
Harmanjit S Hira et al.
Annals of Saudi medicine, 34(4), 308-313 (2015-03-27)
Tissue hypoxia due to repeated apneas among patients of obstructive sleep apnea syndrome (OSAS) leads to cumulative oxidative stress. It is established that an increased plasma level of hypoxanthine/xanthine may serve as a criterion of tissue hypoxia. We presumed that
Gavin C Higgins et al.
Free radical biology & medicine, 53(10), 1960-1967 (2012-09-18)
Neurons can undergo a diverse range of death responses under oxidative stress, encompassing apoptosis (caspase-dependent, programmed cell death) to various forms of caspase-independent death, including necrosis. We recently showed that primary murine cortical neurons exposed acutely to hydrogen peroxide undergo
Masaichi-Chang-Il Lee et al.
Biochemistry, 53(41), 6615-6623 (2014-09-23)
The enzyme xanthine oxidoreductase (XOR) is an important source of oxygen free radicals and related postischemic injury. Xanthine dehydrogenase (XDH), the major form of XOR in tissues, can be converted to xanthine oxidase (XO) by oxidation of sulfhydryl residues or
Claudia Knake et al.
Biochemical and biophysical research communications, 452(1), 157-162 (2014-08-26)
Gout patients receiving a combination of allopurinol and furosemide require higher allopurinol doses to achieve the target serum urate (SU) of <6 mg/dl (Stamp et al., 2012) [1]. Our study aimed to identify the molecular basis for this observation. We
Progress in understanding algal bloom-mediated fish kills: the role of superoxide radicals, phycotoxins and fatty acids
Dorantes-Aranda JJ, et al.
PLoS ONE, 10(7), e0133549-e0133549 (2015)
Phanida Phanthong et al.
Natural product communications, 10(8), 1387-1390 (2015-10-06)
Dolichandrone serrulata (DC.) Seem flowers are widely used as vegetables in northern and eastern Thailand. Biological studies of the methanolic extract of these flowers have shown promising antioxidant activity. Biological-guided separation of D. serrulata flowers yielded six compounds, identified as
Sagiv Weintraub et al.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 20(8), 1287-1298 (2015-11-09)
The search for novel anticancer therapeutic agents is an urgent and important issue in medicinal chemistry. Here, we report on the biological activity of the copper-based bioinorganic complex Cu4 (2,4-di-tert-butyl-6-(1H-imidazo- [1, 10] phenanthrolin-2-yl)phenol)4]·10 CH3CN (2), which was tested in rat
Christian D Laourdakis et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 967, 127-133 (2014-08-05)
Targeted metabolite profiling has aided in the understanding of a variety of biological processes in the malaria parasite as well as in drug discovery. A fast and sensitive analytical method, based on ion-pairing reversed phase ultra-high performance liquid chromatography tandem
Szabolcs Gergely et al.
Oxidative medicine and cellular longevity, 2015, 178513-178513 (2015-07-03)
Antracyclines are effective antitumor agents. One of the most commonly used antracyclines is doxorubicin, which can be successfully used to treat a diverse spectrum of tumors. Application of these drugs is limited by their cardiotoxic effect, which is determined by
Eduardo Molina-Jijón et al.
The Journal of nutritional biochemistry, 26(5), 441-454 (2015-02-24)
We previously reported that diabetes decreased the expression of renal tight junction (TJ) proteins claudin-5 in glomerulus, and claudin-2 and occludin in proximal tubule through an oxidative stress dependent way. Now we investigated whether all-trans retinoic acid (atRA), a compound
A Dăneasă et al.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 122(3), 154-162 (2014-03-20)
Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose tolerance. The purpose of our study is to explore the effect
Osman Raif Karabacak et al.
Urology, 82(3), 532-537 (2013-08-31)
To evaluate the compositions of the kidney stones obtained from different regions of Turkey and to present the gender and regional differences. The study included 6453 kidney stones obtained from patients from different parts of Turkey. All of the stones
Susana Ravassa et al.
Free radical biology & medicine, 81, 1-12 (2015-01-18)
Oxidative stress (OS) contributes to cardiovascular damage in type 2 diabetes mellitus (T2DM). The peptide glucagon-like peptide-1 (GLP-1) inhibits OS and exerts cardiovascular protective actions. Our aim was to investigate whether cardiac remodeling (CR) and cardiovascular events (CVE) are associated
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