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显示 1-30 共 650 条结果 关于 "XTGHP-RO" 范围 论文
X L Bai et al.
Oncogene, 34(31), 4089-4097 (2014-10-21)
Hepatocellular carcinoma (HCC) is one of the leading malignancies worldwide. Myocyte enhancer factor 2C (MEF2C) was traditionally regarded as a development-associated factor and was recently reported to be an oncogene candidate. We have previously reported overexpression of MEF2C in HCC;
Jingwei Yu et al.
Biotechnology letters, 36(6), 1233-1243 (2014-02-25)
MiR-205 plays an important role during adipogenesis by modulating the Wnt signaling pathway. Here, we report that miR-205 can regulate the differentiation of 3T3-L1 preadipocyte cells by targeting glycogen synthase kinase 3 beta (GSK-3β), which is a negative regulatory factor
Tristan T Eifler et al.
Molecular and cellular biology, 35(2), 468-478 (2014-11-12)
Transcriptional cyclin-dependent kinases (CDKs) regulate RNA polymerase II initiation and elongation as well as cotranscriptional mRNA processing. In this report, we describe an important role for CDK12 in the epidermal growth factor (EGF)-induced c-FOS proto-oncogene expression in mammalian cells. This
Jiangnan Li et al.
Virus research, 189, 106-113 (2014-05-31)
Non-structural protein 9 (Nsp9), a RNA-dependent RNA polymerase (RdRp) of the porcine reproductive and respiratory syndrome virus (PRRSV), is necessary for PRRSV replication. However, the binding partners of Nsp9 have not been identified. In this study, seven host proteins were
Reiko Toyama et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 242(9), 1033-1042 (2013-06-12)
The zebrafish pineal gland (epiphysis) is a site of melatonin production, contains photoreceptor cells, and functions as a circadian clock pacemaker. Since it is located on the surface of the forebrain, it is accessible for manipulation and, therefore, is a
Qiang Ding et al.
Journal of hepatology, 59(1), 52-58 (2013-04-02)
Hepatitis C virus (HCV) is a major human viral pathogen that causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. In most cases, acute HCV infection becomes persistent, at least in part due to viral evasion of host innate immune response.
Hong-mei Gu et al.
Journal of lipid research, 54(12), 3345-3357 (2013-10-10)
Proprotein convertase subtilisin kexin-like 9 (PCSK9) promotes the degradation of low density lipoprotein receptor (LDLR) and plays an important role in regulating plasma LDL-cholesterol levels. We have shown that the epidermal growth factor precursor homology domain A (EGF-A) of the
Hong-Mei Gu et al.
Biochimica et biophysica acta, 1841(6), 847-858 (2014-03-01)
ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not
Kai Cui et al.
Integrative biology : quantitative biosciences from nano to macro, 6(12), 1141-1152 (2014-09-16)
The regulation of gene expression by microRNAs (miRNAs) is complex due to a number of variables involved. The potential for one miRNA to target many genes, the presence of multiple miRNA response elements (MREs) in one mRNA molecule and the
Tove Sivik et al.
PloS one, 7(7), e40568-e40568 (2012-07-14)
17β-Hydroxysteroid dehydrogenases (17βHSDs) are important enzymes regulating the pool of bioactive steroids in the breast. The current study was undertaken in order to evaluate implications of 17βHSD14 in breast cancer, measuring 17βHSD14 protein expression in breast tumours. An antibody targeting
Pavan Kumar Puvvula et al.
Nature communications, 5, 5323-5323 (2014-11-20)
Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding RNA PANDA differentially interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription
Holger H H Erb et al.
Endocrine-related cancer, 20(5), 677-689 (2013-08-06)
Development and progression of prostate cancer (PCa) are associated with chronic inflammation. The cytokine interleukin 6 (IL6) can influence progression, differentiation, survival, and angiogenesis of PCa. To identify novel pathways that are triggered by IL6, we performed a gene expression
Anne Mathilde Lund et al.
PloS one, 9(5), e96693-e96693 (2014-06-01)
A new versatile mammalian vector system for protein production, cell biology analyses, and cell factory engineering was developed. The vector system applies the ligation-free uracil-excision based technique--USER cloning--to rapidly construct mammalian expression vectors of multiple DNA fragments and with maximum
Ignacio Caballero et al.
PloS one, 8(1), e39441-e39441 (2013-01-16)
Implantation is a complex process that requires a delicate cooperation between the immune and reproductive system. Any interference in the fine balance could result in embryo loss and infertility. We have recently shown that Toll-like receptor 5 activation results in
Liesbeth Clinckemalie et al.
Molecular endocrinology (Baltimore, Md.), 27(12), 2028-2040 (2013-10-11)
More than 50% of prostate cancers have undergone a genomic reorganization that juxtaposes the androgen-regulated promoter of TMPRSS2 and the protein coding parts of several ETS oncogenes. These gene fusions lead to prostate-specific and androgen-induced ETS expression and are associated
Ana Osorio et al.
Human molecular genetics, 21(13), 2889-2898 (2012-03-28)
RAD51C was defined by Meindl et al. in 2010 as a high-risk gene involved in hereditary breast and ovarian cancers. Although this role seems to be clear, nowadays there is controversy about the indication of including the gene in routine
Keisuke Taniuchi et al.
Neoplasia (New York, N.Y.), 16(12), 1082-1093 (2014-12-17)
Pancreatic cancers are aggressive because they are highly invasive and highly metastatic; moreover, effective treatments for aggressive pancreatic cancers are lacking. Here, we report that the motor kinesin protein KIF20A promoted the motility and invasiveness of pancreatic cancer cells through
Man Chen et al.
Hypertension (Dallas, Tex. : 1979), 64(3), 610-618 (2014-06-11)
Our previous study demonstrated that pregnancy increased large-conductance Ca(2+)-activated potassium channel β1 subunit (BKβ1) expression and large-conductance Ca(2+)-activated potassium channel activity in uterine arteries, which were abrogated by chronic hypoxia. The present study tested the hypothesis that promoter methylation/demethylation is
Juping Wang et al.
Oncotarget, 5(20), 9727-9743 (2014-09-03)
Numerous studies have shown that various cancer cells express immunoglobulin G (IgG). However, the function of cancer-derived IgG and the underlying mechanism remain unclear. In this study, we demonstrated that IgG expression was significantly altered after exposure to LPS in
Yongfeng Li et al.
Virus research, 189, 67-74 (2014-05-13)
Real-time fluorescence imaging of viral proteins in living cells is a valuable means to study virus-host interactions, and tetracysteine (TC)-biarsenical technology has been used in several viruses but not in classical swine fever virus (CSFV). Here, we generated CSFV mutants
Andrew Nickerson et al.
PloS one, 9(6), e100589-e100589 (2014-06-26)
Bimolecular fluorescence complementation (BiFC) has been widely used to visualize protein-protein interactions (PPIs) in cells. Until now, however, the resolution of BiFC has been limited by the diffraction of light to ∼250 nm, much larger than the nanometer scale at
Hitomi Tsuiji et al.
EMBO molecular medicine, 5(2), 221-234 (2012-12-21)
Two motor neuron diseases, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA), are caused by distinct genes involved in RNA metabolism, TDP-43 and FUS/TLS, and SMN, respectively. However, whether there is a shared defective mechanism in RNA metabolism common
Jianfei Xue et al.
The Journal of clinical investigation, 124(2), 564-579 (2014-01-03)
A key feature of TGF-β signaling activation in cancer cells is the sustained activation of SMAD complexes in the nucleus; however, the drivers of SMAD activation are poorly defined. Here, using human and mouse breast cancer cell lines, we found
Yuan Lu et al.
The Journal of clinical investigation, 123(10), 4232-4241 (2013-09-04)
Activation of cells intrinsic to the vessel wall is central to the initiation and progression of vascular inflammation. As the dominant cellular constituent of the vessel wall, vascular smooth muscle cells (VSMCs) and their functions are critical determinants of vascular
J J Havel et al.
Oncogene, 34(12), 1487-1498 (2014-04-08)
The ribosomal protein (RP)-HDM2-p53 pathway has been shown to have key roles in oncogene-induced apoptosis and senescence, but the mechanism regulating this pathway remains elusive. The proline-rich Akt substrate of 40 kDa (PRAS40) has recently been identified as a binding partner and
Wei-qi Dang et al.
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology, 28(11), 1204-1207 (2012-11-07)
To construct and identify a lentivirus-mediated short hairpin RNA (shRNA) targeting human signal transducer and activator of transcription 3 (STAT3) gene. The shRNA chains targeting to human STAT3 gene were designed and synthesized, and then inserted into lentivirus expression vector
Dilip Rajasekhar Maddirela et al.
International journal of oncology, 42(4), 1279-1288 (2013-02-06)
The majority of glioblastoma multiforme (GBM) tumors recur after radiation (IR) treatment due to increased angiogenesis and IR-induced signaling events in endothelial cells (ECs) that are involved in tumor neovascularization; however, these signaling events have yet to be well characterized.
Hyun Suk Ko et al.
Journal of agricultural and food chemistry, 60(16), 4083-4089 (2012-04-07)
Cancer invasion and metastasis are the main causes of treatment failure and death in cancer patients. Piceatannol (3,3',4,5'-tetrahydroxy-trans-stilbene) is a natural analogue of resveratrol. This study investigated the anti-invasive mechanisms of piceatannol in MDA-MB-231 cells. Piceatannol significantly reduced serum-induced cell
Kaifan Yu et al.
The FEBS journal, 281(10), 2399-2409 (2014-03-29)
Adipose tissue is crucial for energy homeostasis and is a topic interest with respect to investigating the regulation of adipose tissue formation for the ever-increasing health concerns of obesity and type 2 diabetes. Adipocyte differentiation is tightly regulated by the
Santanu Banerjee et al.
Scientific reports, 3, 1977-1977 (2013-06-13)
Development of tolerance to endotoxin prevents sustained hyper inflammation during systemic infections. Here we report for the first time that chronic morphine treatment tempers endotoxin tolerance resulting in persistent inflammation, septicemia and septic shock. Morphine was found to down-regulate endotoxin/LPS
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