搜索范围
XTGHP-RO
应用筛选条件
关键词:'XTGHP-RO'
显示 1-30 #N/A 650 条结果 关于 "XTGHP-RO" 范围 论文
David R Friedmann et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(48), 19655-19660 (2012-10-17)
Protein acetylation is an important posttranslational modification with the recent identification of new substrates and enzymes, new links to disease, and modulators of protein acetylation for therapy. α-Tubulin acetyltransferase (αTAT1) is the major α-tubulin lysine-40 (K40) acetyltransferase in mammals, nematodes
Navasona Krishnan et al.
Nature chemical biology, 10(7), 558-566 (2014-05-23)
PTP1B, a validated therapeutic target for diabetes and obesity, has a critical positive role in HER2 signaling in breast tumorigenesis. Efforts to develop therapeutic inhibitors of PTP1B have been frustrated by the chemical properties of the active site. We define
Ge-Er Zhang et al.
International journal of molecular sciences, 14(7), 13005-13021 (2013-06-26)
Mitofusin-2 (Mfn2) is a mitochondrial outer membrane protein involved in mitochondrial fusion. Its mutation can cause Charcot-Marie-Tooth disease. Recent studies of Mfn2 in cancer research have not included gastric cancer. We confirmed that Mfn2 expression was lower in tumor tissue
Lu Zhang et al.
Biochimica et biophysica acta, 1853(2), 377-387 (2014-12-06)
Macroautophagy (autophagy) is an important factor affecting the function of vascular endothelial cells (VECs) and must be tightly regulated in these cells. However, the precise mechanisms underlying this process, particularly in the presence of serum, remain obscure. In this study
Meritxell Morró et al.
Human gene therapy, 25(9), 824-836 (2014-07-22)
Pancreatic gene transfer could be useful to treat several diseases, such as diabetes mellitus, cystic fibrosis, chronic pancreatitis, or pancreatic cancer. Helper-dependent adenoviral vectors (HDAds) are promising tools for gene therapy because of their large cloning capacity, high levels of
R Krishnan Kutty et al.
Molecular vision, 19, 737-750 (2013-04-18)
The inflammatory response of the retinal pigment epithelium (RPE) is implicated in the pathogenesis of age-related macular degeneration. The microRNAs miR-146a and miR-146b-5p can regulate the inflammatory process by attenuating cytokine signaling via the nuclear factor-κB pathway. The aim of
Vincenzo D'Angiolella et al.
Cell, 149(5), 1023-1034 (2012-05-29)
F-box proteins are the substrate binding subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes. Using affinity purifications and mass spectrometry, we identified RRM2 (the ribonucleotide reductase family member 2) as an interactor of the F-box protein cyclin F. Ribonucleotide reductase
Inhibition of protein phosphatase 2A enhances cytotoxicity and accessibility of chemotherapeutic drugs to hepatocellular carcinomas.
Bai XL, Zhang Q, Ye LY, et al.
Molecular Cancer Therapeutics, 13(8), 2062-2072 (2014)
Xing-Hua Liao et al.
Virus research, 192, 85-91 (2014-08-27)
Human cytomegalovirus (HCMV) may increase the incidence of restenosis and predispose to atherosclerosis. The lesions of restenosis and atherosclerosis often contain smooth muscle cells (SMCs) with high rates of proliferation and apoptosis. One of the immediate early (IE) gene products
Takeshi Chiyomaru et al.
The Journal of biological chemistry, 289(18), 12550-12565 (2014-03-13)
HOTAIR is a long non-coding RNA that interacts with the polycomb repressive complex and suppresses its target genes. HOTAIR has also been demonstrated to promote malignancy. MicroRNA-141 (miR-141) has been reported to play a role in the epithelial to mesenchymal
Characterization of conserved region 2-deficient mutants of the cytomegalovirus egress protein pM53.
Madlen Pogoda et al.
Journal of virology, 86(23), 12512-12524 (2012-09-21)
Dominant-negative (DN) mutants are powerful tools for studying essential protein-protein interactions. A systematic genetic screen of the essential murine cytomegalovirus (MCMV) protein pM53 identified the accumulation of inhibitory mutations within conserved region 2 (CR2) and CR4. The strong inhibitory potential
Sebastian Ahrens et al.
The Journal of biological chemistry, 288(2), 1397-1408 (2012-11-28)
Vibrio cholerae is the causative agent of the severe diarrheal disease cholera. For V. cholerae to colonize the intestinal epithelium, accessory toxins such as the multifunctional autoprocessing repeats-in-toxin (MARTX(Vc)) toxin are required. MARTX toxins are composite toxins comprised of arrayed
Cynthia R Hill et al.
Cellular signalling, 24(5), 1012-1022 (2012-01-13)
Coronary vessel development depends on a subpopulation of epicardial cells that undergo epithelial to mesenchymal transformation (EMT) and invade the subepicardial space and myocardium. These cells form the smooth muscle of the vessels and fibroblasts, but the mechanisms that regulate
Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity.
Tao L, Wang S, Zhao Y, et al.
Phytomedicine, 21(11), 1473-1482 (2014)
Guoliang Li et al.
Molecular medicine reports, 13(3), 2467-2475 (2016-02-06)
Mutations in the human ether‑à‑go‑go‑related gene (hERG) are responsible for long‑QT syndrome (LQTS) type 2 (LQT2). In the present study, a heterozygous missense mutation (A561V) linked to LQT2, syncope and epilepsy was identified in the S5/pore region of the hERG
Hong Sun et al.
Anti-cancer drugs, 23(10), 1039-1046 (2012-07-05)
Nuclear factor-κB (NF-κB) and Akt are two major cell-survival pathways that are often constitutively activated in cancer cells. It has been established that these two pathways contribute substantially toward the chemoresistance of cancer cells. Our previous study has demonstrated that
Bruno Correia et al.
PLoS pathogens, 9(10), e1003673-e1003673 (2013-10-23)
Latency-associated nuclear antigen (LANA) mediates γ2-herpesvirus genome persistence and regulates transcription. We describe the crystal structure of the murine gammaherpesvirus-68 LANA C-terminal domain at 2.2 Å resolution. The structure reveals an alpha-beta fold that assembles as a dimer, reminiscent of
Xiangjing Gao et al.
PloS one, 9(5), e97174-e97174 (2014-05-14)
Paraspeckle protein 1 (PSPC1) was first identified as a structural protein of the subnuclear structure termed paraspeckle. However, the exact physiological functions of PSPC1 are still largely unknown. Previously, using a proteomic approach, we have shown that exposure to cisplatin
Louise Giffin et al.
Journal of virology, 88(16), 9429-9441 (2014-06-13)
Kaposi's sarcoma-associated herpesvirus (KSHV, also called human herpesvirus 8) is linked to the development of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). KSHV expresses several proteins that modulate host cell signaling pathways. One of these
Ramon Y Birnbaum et al.
PLoS genetics, 10(10), e1004592-e1004592 (2014-10-24)
In addition to their protein coding function, exons can also serve as transcriptional enhancers. Mutations in these exonic-enhancers (eExons) could alter both protein function and transcription. However, the functional consequence of eExon mutations is not well known. Here, using massively
Zehua Wang et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(8), 3053-3058 (2012-02-09)
Androgen signaling through androgen receptor (AR) is critical for prostate tumorigenesis. Given that AR-mediated gene regulation is enhanced by AR coregulators, inactivation of those coregulators is emerging as a promising therapy for prostate cancer (PCa). Here, we show that the
Kiyohiro Ando et al.
Molecular cell, 47(5), 681-693 (2012-08-03)
Biochemical evidence implicates the death-domain (DD) protein PIDD as a molecular switch capable of signaling cell survival or death in response to genotoxic stress. PIDD activity is determined by binding-partner selection at its DD: whereas recruitment of RIP1 triggers prosurvival
Dana A Dodd et al.
mBio, 5(3), e01178-e01114 (2014-06-06)
Haemophilus ducreyi causes chancroid, a sexually transmitted infection. A primary means by which this pathogen causes disease involves eluding phagocytosis; however, the molecular basis for this escape mechanism has been poorly understood. Here, we report that the LspA virulence factors
An atrial-fibrillation-linked connexin40 mutant is retained in the endoplasmic reticulum and impairs the function of atrial gap-junction channels.
Sun Y, Tong X, Chen H, et al.
Disease models & mechanisms, 7(5), 561-569 (2014)
Shuqi Xiao et al.
Journal of virology, 89(8), 4494-4503 (2015-02-06)
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important viruses affecting the swine industry worldwide. Our previous research showed that PRRSV downregulates the expression of heme oxygenase-1 (HO-1), a pivotal cytoprotective enzyme, postinfection and that
Zhuoming Liu et al.
Journal of molecular medicine (Berlin, Germany), 90(10), 1209-1221 (2012-04-25)
Siderophores are best known as small iron binding molecules that facilitate microbial iron transport. In our previous study we identified a siderophore-like molecule in mammalian cells and found that its biogenesis is evolutionarily conserved. A member of the short chain
Jiaxu Liu et al.
BMC veterinary research, 10, 964-964 (2014-12-22)
The virulent Newcastle disease virus (NDV) strain NA-1 (genotype VII) was isolated from an epizootic involving a flock of geese in Jilin Province, Northeast China, in 1999. Compared with the classical NDV strains, which have a genome size of 15,186
Sabine Hulpke et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 26(12), 5071-5080 (2012-08-28)
The loading of antigen-derived peptides onto MHC class I molecules for presentation to cytotoxic T cells is a key process in adaptive immune defense. Loading of MHC I is achieved by a sophisticated machinery, the peptide-loading complex (PLC), which is
Shigenori Nagae et al.
Genes to cells : devoted to molecular & cellular mechanisms, 18(5), 387-396 (2013-02-26)
Animal cells contain two populations of microtubules: one radiating from the centrosome and the other growing from non-centrosomal sites. Whether or not they have differing roles in cellular architecture and function remains not fully understood. The cytoplasmic protein Nezha (also
William N Addison et al.
Molecular and cellular biology, 34(16), 3076-3085 (2014-06-04)
Osteoblasts and adipocytes arise from a common mesenchymal precursor cell. The cell fate decision of a mesenchymal precursor cell is under the influence of molecular cues and signaling pathways that lead to the activation or repression of lineage-specific transcription factors.
1/22