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V S Eckle et al.
British journal of anaesthesia, 114(3), 491-498 (2014-08-26)
Surgical interventions like skin incisions trigger withdrawal reflexes which require motor neurones and local circuit interneurones in the spinal ventral horn. This region plays a key role in mediating immobilizing properties of the GABAergic anaesthetic propofol. However, it is unclear
Nan Hu et al.
Drug metabolism and pharmacokinetics, 29(3), 229-236 (2013-11-22)
Oxyresveratrol (OXY) is a natural hydroxystilbene that shows similar bioactivity but better water solubility than resveratrol. This study aims to characterize its glucuronidation kinetics in human liver (HLMs) and intestinal (HIMs) microsomes and identify the main UDP-glucuronosyltransferase (UGT) isoforms involved.
Seung Jun Lee et al.
Toxicology letters, 232(2), 458-465 (2014-12-03)
In the present study, we evaluated the inhibitory potentials of finasteride for the major human hepatic UDP-glucuronosyltransferases (UGTs) (UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, and UGT2B15) in vitro using LC-MS/MS by specific marker reactions in human liver microsomes (except for
Death row incurs drug penalty.
Chris Woolston
Nature, 502(7472), 417-418 (2013-10-25)
Seiji Kawano et al.
Digestion, 91(2), 112-116 (2015-02-14)
Because peroral double-balloon endoscopy (DBE) is a time-consuming, painful procedure, sedation with analgesics, and/or anesthetics is generally required. The aim of this prospective study was to investigate the safety and efficacy of our sedation protocol for peroral DBE, which consisted
I Padrutt et al.
Research in veterinary science, 99, 23-29 (2015-02-05)
Incretin analogues and inhibitors of the breakdown of endogenous incretins are antidiabetic drugs that increase β-cell proliferation and glucose-stimulated insulin secretion in rodents and humans. Objectives were to test whether exenatide, exenatide extended-release, and sitagliptin can be safely used in
Yi Zhang et al.
Journal of pharmacological sciences, 126(4), 370-381 (2014-11-28)
The effects of anesthetics on the transmission and processing of sensory information within the thalamocortical pathway and the underlying mechanism are not fully understood. Using the extracellular recording technique, we investigated the changes of spontaneous and stimulation-evoked activities within and
Yasushi Koike et al.
Masui. The Japanese journal of anesthesiology, 62(4), 449-452 (2013-05-24)
A 64-year-old woman was scheduled for the removal of hepatic cystadenoarcinoma. The preoperative examination did not reveal any neurological disorders. Anesthesia was induced with midazolam (5 mg) and remifentanil (0.1.ag x kg-1 x min-1) and the trachea was intubated following
Byung-Moon Choi et al.
Journal of pharmacokinetics and pharmacodynamics, 42(2), 163-177 (2015-03-01)
There have been no pharmacokinetic parameters and blood-brain equilibration rate constant (k e0) of propofol obtained in a single population of children, by which propofol can be administered using a target effect-site concentration controlled infusion. Thirty-nine, American Society of Anesthesiologists
Susan T Herman et al.
Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society, 32(2), 96-108 (2015-01-30)
Critical Care Continuous EEG (CCEEG) is a common procedure to monitor brain function in patients with altered mental status in intensive care units. There is significant variability in patient populations undergoing CCEEG and in technical specifications for CCEEG performance. The
Katarzyna Wawrzyniak et al.
International forum of allergy & rhinology, 4(7), 542-547 (2014-03-05)
Inadequate surgical field visualization due to intraoperative bleeding during endoscopic sinus surgery (ESS) can cause major complications. The aim of this prospective study was to compare the effect of preoperative administration of clonidine and melatonin on the quality of the
L Chen et al.
Anaesthesia and intensive care, 41(6), 742-749 (2013-11-05)
Flexible fibreoptic bronchoscopy is an important tool in the evaluation and management of paediatric respiratory disease. Total intravenous anaesthesia (TIVA) and volatile agent induction and maintenance of anaesthesia (VIMA) are commonly used for these procedures. The aim of this study
Andreas Alexandrou et al.
Journal of investigative surgery : the official journal of the Academy of Surgical Research, 28(1), 8-17 (2014-09-03)
To evaluate the association between the Bsm1 vitamin D receptor polymorphism and the calcium-vitamin D-parathormone axis following bariatric surgery. This cross-sectional study included 86 morbidly obese patients, who underwent either gastric bypass or sleeve gastrectomy, with a mean follow-up of
Katarzyna Wawrzyniak et al.
Clinical and experimental otorhinolaryngology, 7(4), 307-311 (2014-12-02)
Premedication with clonidine has been found to reduce the bleeding during endoscopic sinus surgery (ESS), therefore lowering the risk of surgical complications. Premedication is an essential part of pre-surgical care and can potentially affect magnitude of systemic stress response to
Jing Song et al.
PloS one, 9(12), e114440-e114440 (2014-12-17)
Propofol (2, 6-diisopropylphenol) is an intravenous sedative-hypnotic agent administered to induce and maintain anesthesia. It has been recently revealed that propofol has anticancer properties including direct and indirect suppression of the viability and proliferation of cancer cells by promoting apoptosis
Xiao-Yu Yang et al.
International journal of clinical pharmacology and therapeutics, 53(1), 32-40 (2014-12-17)
Hemodynamic stability is one of the most critical concerns during induction of anesthesia. Whether the pharmacokinetic model by Marsh or the one by Schnider will produce better hemodynamic stability remains unclear. This study compared hemodynamic changes during induction between the
C Creeley et al.
British journal of anaesthesia, 110 Suppl 1, i29-i38 (2013-06-05)
Exposure of the fetal or neonatal non-human primate (NHP) brain to isoflurane or ketamine for 5 h causes widespread apoptotic degeneration of neurones, and exposure to isoflurane also causes apoptotic degeneration of oligodendrocytes (OLs). The present study explored the apoptogenic
Andrew Rowland et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(1), 147-153 (2014-11-09)
This study characterized the kinetics, variability, and factors that affect UDP-glucuronic acid (UDP-GlcUA) uptake by human liver microsomes (HLM). Biphasic kinetics were observed for UDP-GlcUA uptake by HLM. Uptake affinities (assessed as Kd) of the high- and low-affinity components differed
No difference in blood loss during endoscopic sinus surgery with total intravenous anesthesia?
Luca La Colla et al.
JAMA otolaryngology-- head & neck surgery, 139(10), 1077-1077 (2013-10-19)
Jan Hoffmann et al.
Neurobiology of disease, 74, 137-143 (2014-12-03)
To examine the effect of the orexinergic blockade with a dual orexin receptor antagonist (DORA) on experimental models of peripheral and central trigeminal as well as cortical activation relevant to migraine and migraine aura. In this study we used a
M Mukai et al.
Die Pharmazie, 69(11), 829-832 (2015-05-20)
Propofol (2,6-diisopropylphenol) is intravenously administered for anesthetic induction and maintenance, and is rapidly metabolized into its glucuronide, mainly by UDP-glucuronosyltransferase 1A9 (UGT1A9). In this study, propofol glucuronidation by liver microsomes (HLM), intestinal microsomes (HIM) and kidney microsomes (HKM) of humans
Kyra J Barnes et al.
European journal of clinical pharmacology, 70(9), 1097-1106 (2014-06-24)
To investigate the potential inhibitory effects of uremic toxins on the major human hepatic drug-metabolising cytochrome P450 (CYP) and UDP-glucuronosyltransferase (UGT) enzymes in vitro. Benzyl alcohol, p-cresol, indoxyl sulfate, hippuric acid and a combination of the four uremic toxins were
Jonas Sanberg Jensen et al.
The Journal of surgical research, 193(1), 145-152 (2014-08-27)
The antitumor necrosis factor (infliximab [IFX]) has gained widespread use in the treatment of inflammatory bowel disease. However, several patients must undergo surgical treatment due to treatment failure and there is a potential risk that preoperative IFX treatment may have
W-K Lee et al.
British journal of anaesthesia, 114(4), 663-668 (2014-12-17)
Two common general anaesthetic methods are total i.v. anaesthesia (TIVA) and inhalation anaesthesia, but it is unclear whether this affects the patient's perception of their quality of recovery. The Quality of Recovery-40 questionnaire (QoR-40) is a valid and reliable method
Brett Tortelli et al.
Human molecular genetics, 23(22), 6022-6033 (2014-06-27)
Niemann-Pick C1 (NPC1) disease is a rare, neurodegenerative lysosomal cholesterol storage disorder, typified by progressive cognitive and motor function impairment. Affected individuals usually succumb to the disease in adolescence. 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD) has emerged as a promising intervention that reduces lipid
Takayuki Kunisawa et al.
Journal of anesthesia, 29(2), 198-205 (2014-09-05)
We previously determined the pharmacokinetic (PK) parameters of landiolol in healthy male volunteers. In this study, we evaluated the usefulness of target-controlled infusion (TCI) of landiolol hydrochloride and determined PK parameters of landiolol in gynecologic patients. Nine patients who were
Amanda R Taylor et al.
Journal of neurotrauma, 31(18), 1561-1569 (2014-05-03)
Canine intervertebral disk herniation (IVDH) is a common, naturally occurring form of spinal cord injury (SCI) that is increasingly being used in pre-clinical evaluation of therapies. Although IVDH bears critical similarities to human SCI with respect to lesion morphology, imaging
Selma Sirin et al.
Investigative radiology, 50(1), 32-39 (2014-09-13)
Magnetic resonance colonography (MRC) is a well-accepted, noninvasive imaging modality for the depiction of inflammatory bowel disease. Diffusion-weighted imaging (DWI) is very helpful to display inflammatory lesions. The aim of this retrospective study was to assess whether intravenous contrast is
Soo Hyeon Bae et al.
Antimicrobial agents and chemotherapy, 58(9), 5036-5046 (2014-06-04)
Macrolactin A (MA) and 7-O-succinyl macrolactin A (SMA), polyene macrolides containing a 24-membered lactone ring, show antibiotic effects superior to those of teicoplanin against vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus. MA and SMA are currently being evaluated as antitumor agents
David Kylhammar et al.
European journal of applied physiology, 114(9), 1995-2006 (2014-06-16)
To investigate the role of P2Y₁ and P2Y₁₂ receptors in hypoxia- and adenosine diphosphate (ADP)-induced pulmonary vasoconstriction. 19 anaesthetized, mechanically ventilated pigs (31.3 ± 0.7 kg) were evaluated in normoxia and hypoxia, without (n = 6) or with P2Y₁ receptor
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