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Pancuronium bromide: a review of its pharmacological properties and clinical application.
T M Speight et al.
Drugs, 4(3), 163-226 (1972-01-01)
Ken-ichi Arita-Morioka et al.
Antimicrobial agents and chemotherapy, 59(1), 633-641 (2014-11-19)
Biofilms are complex communities of microorganisms that attach to surfaces and are embedded in a self-produced extracellular matrix. Since these cells acquire increased tolerance against antimicrobial agents and host immune systems, biofilm-associated infectious diseases tend to become chronic. We show
Andrew Curtright et al.
PloS one, 10(1), e0116766-e0116766 (2015-01-15)
Acute and chronic pain conditions are often debilitating, inflicting severe physiological, emotional and economic costs and affect a large percentage of the global population. However, the development of therapeutic analgesic agents based primarily on targeted drug development has been largely
J Simoes et al.
Journal of perinatology : official journal of the California Perinatal Association, 9(2), 215-218 (1989-06-01)
Nursing care of the newborn in respiratory distress has become highly sophisticated and technical, requiring skill in principles of neonatal assessment and therapeutic interventions. It is important to be knowledgeable about the technical aspects of the equipment and monitors. However
F Zoerner et al.
Acta anaesthesiologica Scandinavica, 59(4), 465-474 (2015-03-20)
Long-term survival after cardiac arrest (CA) due to shock-refractory ventricular fibrillation (VF) is low. Clearly, there is a need for new pharmacological interventions in the setting of cardiopulmonary resuscitation (CPR) to improve outcome. Here, hemodynamic parameters and cardiac damage are
Alina Teliban et al.
Journal of neurophysiology, 111(10), 2071-2083 (2014-02-28)
Intact and injured cutaneous C-fibers in the rat sural nerve are cold sensitive, heat sensitive, and/or mechanosensitive. Cold-sensitive fibers are either low-threshold type 1 cold sensitive or high-threshold type 2 cold sensitive. The hypothesis was tested, in intact and injured
Cristiana Marcozzi et al.
Experimental lung research, 41(4), 228-240 (2015-04-07)
To investigate the regional gravity-dependent impact of mechanical ventilation and fluid overload on lung extracellular matrix (ECM) in healthy lungs. The glycosaminoglycans (GAGs) composition of the ventral and dorsal lung parenchyma was determined in anesthetized supine healthy rats mechanically ventilated
Kun-Ze Lee et al.
Experimental neurology, 263, 314-324 (2014-12-03)
Repeated exposure to hypoxia can induce spinal neuroplasticity as well as respiratory and somatic motor recovery after spinal cord injury (SCI). The purpose of the present study was twofold: to define the capacity for a single bout of hypoxia to
M Bączyk et al.
The Journal of physiology, 592(19), 4313-4328 (2014-08-03)
The main aim of the present study was to examine to what extent long-lasting subcortical actions of transcranial direct current stimulation (tDCS) may be related to its presynaptic actions. This was investigated in the red nucleus, where tDCS was recently
Alonso G P Guedes et al.
American journal of physiology. Lung cellular and molecular physiology, 308(5), L485-L493 (2015-01-13)
CD38 is a cell-surface protein involved in calcium signaling and contractility of airway smooth muscle. It has a role in normal airway responsiveness and in airway hyperresponsiveness (AHR) developed following airway exposure to IL-13 and TNF-α but appears not to
Peter Halvorsen et al.
Upsala journal of medical sciences, 120(1), 11-19 (2015-02-04)
Our aim was to investigate cerebral and cardiac tissue injury subsequent to use of vasopressin and adrenaline in combination compared with vasopressin alone during cardiopulmonary resuscitation (CPR). In a randomized, prospective, laboratory animal study 28 anesthetized piglets were subject to
Corinna Scheffel et al.
Toxicology letters, 232(3), 557-565 (2014-12-20)
Poisoning by organophosphorus compounds (OP) used as pesticides and nerve agents is due to irreversible inhibition of the enzyme acetylcholinesterase (AChE). Oximes have been widely recognized for their potency to reactivate the inhibited enzyme. The limited efficacy of currently available
Erik Sjögren et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 214-223 (2013-10-01)
The pharmacokinetics (PK) of fexofenadine (FEX) in pigs were investigated with the focus on exploring the interplay between hepatic transport and metabolism when administered intravenously (iv) alone or with verapamil. The in vivo pig model enabled simultaneous sampling from plasma
The slow death of lethal injection.
Owen Dyer
BMJ (Clinical research ed.), 348, g2670-g2670 (2014-05-02)
M F Roizen et al.
Annals of internal medicine, 88(1), 64-68 (1978-01-01)
Pancuronium bromide is a nondepolarizing muscle relaxant approved to induce skeletal muscle relaxation during anesthesia and to facilitate the management of patients undergoing mechanical ventilation. The use of pancuronium bromide during surgery led to the appreciation that it has advantages
F Bolzoni et al.
The Journal of physiology, 593(4), 947-966 (2014-11-25)
Trans-spinal DC stimulation affects both postsynaptic neurons and the presynaptic axons providing input to these neurons. In the present study, we show that intraspinally applied cathodal current replicates the effects of trans-spinal direct current stimulation in deeply anaesthetized animals and
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