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Leena Chularojanamontri et al.
Journal of drugs in dermatology : JDD, 11(10), e43-e47 (2012-11-09)
Even though proton pump inhibitors (PPIs) are commonly used in clinical practice, a limited number of studies are available about cutaneous adverse reactions from PPIs, and most of these are case reports. To demonstrate the pattern of cutaneous reactions related
Thi Viet Ha Nguyen et al.
Helicobacter, 17(4), 319-325 (2012-07-05)
Low Helicobacter pylori eradication rates are common in pediatric trials especially in developing countries. The aim of the study was to investigate the role of antibiotic resistance, drug dosage, and administration frequency on treatment outcome for children in Vietnam. Antibiotics
Aneta Novotna et al.
PloS one, 9(8), e105580-e105580 (2014-08-21)
Benzimidazole drugs lansoprazole and omeprazole are used for treatment of various gastrointestinal pathologies. Both compounds cause drug-drug interactions because they activate aryl hydrocarbon receptor and induce CYP1A genes. In the current paper, we examined the effects of lansoprazole and omeprazole
Jyh-Ming Liou et al.
Lancet (London, England), 381(9862), 205-213 (2012-11-20)
Whether sequential treatment can replace triple therapy as the standard treatment for Helicobacter pylori infection is unknown. We compared the efficacy of sequential treatment for 10 days and 14 days with triple therapy for 14 days in first-line treatment. For
Education and imaging. Gastrointestinal: colonic mucosa-associated lymphoid tissue lymphoma regressed by levofloxacin.
T Matsumoto et al.
Journal of gastroenterology and hepatology, 28(4), 750-750 (2013-03-27)
Jun-Won Chung et al.
Journal of gastroenterology and hepatology, 27(11), 1675-1680 (2012-08-02)
Increased resistance of Helicobacter pylori to antibiotics has increased the need to develop new first-line treatments for H. pylori. We have prospectively evaluated 10-day sequential versus conventional triple therapy in peptic ulcer patients. One hundred and fifty-nine patients with peptic ulcer
Jeong Hwan Kim et al.
Digestive diseases and sciences, 58(6), 1663-1667 (2013-02-28)
The association of gastroesophageal reflux disease (GERD) and laryngeal symptoms is not clear. We aimed to examine the symptomatic and endoscopic relations between GERD and laryngeal symptoms and also to evaluate the response to a 2-week proton pump inhibitor (PPI)
Tina Kiffer-Moreira et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 28(1), 81-91 (2012-08-14)
Medial vascular calcification (MVC) is common in patients with chronic kidney disease, obesity, and aging. MVC is an actively regulated process that resembles skeletal mineralization, resulting from chondro-osteogenic transformation of vascular smooth muscle cells (VSMCs). Here, we used mineralizing murine
Yasunobu Yamashita et al.
PloS one, 9(5), e97419-e97419 (2014-05-23)
Lansoprazole is a potent anti-gastric ulcer drug that inhibits gastric proton pump activity. We identified a novel function for lansoprazole, as an inducer of anti-oxidative stress responses in the liver. Gastric administration of lansoprazole (10-100 mg/kg) to male Wistar rats
Hiroto Miwa et al.
Journal of gastroenterology and hepatology, 30(5), 834-841 (2015-01-07)
Non-erosive reflux disease (NERD) and functional dyspepsia (FD) share some common features, and the appropriateness of managing these diseases independently has been questioned. A post-hoc subgroup analysis of the LEGEND study was performed to compare demographics and treatment response between
Aneta Novotna et al.
PloS one, 9(6), e98711-e98711 (2014-06-03)
Proton pump inhibitors omeprazole and lansoprazole contain chiral sulfur atom and they are administered as a racemate, i.e. equimolar mixture of S- and R-enantiomers. The enantiopure drugs esomeprazole and dexlansoprazole have been developed and introduced to clinical practice due to
D A Peura et al.
Alimentary pharmacology & therapeutics, 37(8), 810-818 (2013-03-05)
Higher body mass index (BMI) is a recognised risk factor for gastro-oesophageal reflux disease (GERD). Data regarding the impact of BMI on proton pump inhibitor (PPI) therapy are conflicting. To assess the impact of BMI on baseline heartburn symptom severity
Nahuai Badiola et al.
PloS one, 8(3), e58837-e58837 (2013-03-23)
A key event in the pathogenesis of Alzheimer's disease (AD) is the accumulation of amyloid-β (Aβ) species in the brain, derived from the sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretases. Based on a systems biology
Christel A S Bergström et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 57, 224-231 (2013-10-01)
In this paper we analyse how the biopharmaceutics classification system (BCS) has been used to date. A survey of the literature resulted in a compilation of 242 compounds for which BCS classes were reported. Of these, 183 compounds had been
Grace Chai et al.
Pediatrics, 130(1), 23-31 (2012-06-20)
To describe trends in outpatient prescription drug utilization in US children and the changes in major areas of pediatric therapeutic use for the years 2002 through 2010. Large prescription databases (the IMS Vector One: National and Total Patient Tracker) were
Ichiro Ieiri et al.
International journal of clinical pharmacology and therapeutics, 50(10), 689-700 (2012-08-03)
To test whether the multiple phenotype and genotype relationships established using therapeutic dose, can be reproduced following oral microdosing using substrates of CYP2C9 (warfarin and glibenclamide), CYP2C19 (lansoprazole), CYP2D6 (dextromethorphan), and OATPs (glibenclamide). A cocktail of test drugs was administered
Ken Haruma et al.
Internal medicine (Tokyo, Japan), 54(7), 695-701 (2015-04-04)
Although gastroesophageal reflux disease (GERD), a very common disorder worldwide, is considered to be a lifestyle disease, the pathogenic role of lifestyle factors and consequently the efficacy of lifestyle interventions, remains controversial. Lifestyle factors associated with GERD and the beneficial
Hala H Mosli et al.
The Journal of clinical endocrinology and metabolism, 97(9), E1731-E1735 (2012-06-23)
Chromogranin A (CgA) is used as a generic tumor marker for neuroendocrine tumors. Proton pump inhibitors (PPI) are known to increase CgA, but it is not clear to what extent, and there is little information on how long PPI need
Kazuhiro Iguchi et al.
Oncology letters, 7(5), 1665-1668 (2014-04-26)
Prostate cancer occurs more frequently among older males and such elderly individuals often have chronic underlying disorders for which various drugs are administered for treatment. The levels of prostate-specific antigen (PSA), a widely used prostate cancer marker, are influenced by
Yuanlong Xu et al.
Pakistan journal of pharmaceutical sciences, 26(3), 495-502 (2013-04-30)
As a representative proton pump inhibitor, Lansoprazole was poorly soluble in water which caused the low oral bioavailability. The present study was carried out to enhance the dissolution of lansoprazole by cogrinding with some commonly used hydrophilic polymers (β-CD, PVP
Douglas R Morgan et al.
JAMA, 309(6), 578-586 (2013-02-14)
The long-term effectiveness of Helicobacter pylori eradication programs for preventing gastric cancer will depend on recurrence risk and individual and community factors. To estimate risk of H. pylori recurrence and assess factors associated with successful eradication 1 year after treatment.
Ryohkan Funakoshi et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132(5), 601-607 (2012-06-13)
The urea breath test (UBT) is used widely for assessment of Helicobacter pylori (H. pylori) eradication after treatment. A false-negative UBT is common during administration of anti-ulcer drugs and immediately after their discontinuation. It was thought that the pharmaceutical care
[Is sequential eradication of Helicobacter pylori effective? Sequential treatment more effective than triple therapy in patients with clarithromycin resistance].
P Malfertheiner
Deutsche medizinische Wochenschrift (1946), 138(13), 628-628 (2013-03-21)
Hiroshi Satoh
Current pharmaceutical design, 19(1), 67-75 (2012-09-07)
The proton pump inhibitors (PPIs) lansoprazole (LPZ) and omeprazole (OPZ) have been widely used for more than 20 years in the treatment of acid-related diseases such as gastro-duodenal ulcers and reflux esophagitis. Both LPZ and OPZ are derivatives of 2-[(2-
Carlos Areche et al.
Organic & biomolecular chemistry, 12(33), 6406-6413 (2014-07-11)
Four new mulinane-type diterpenoids besides the known compounds mulin-11,13-dien-20-oic acid, 13α-hydroxyazorellane, 13β-hydroxyazorellane, mulinolic acid, azorellanol, and mulin-11,13-dien-18-acetoxy-16,20-dioic acid were isolated from the Chilean plant Azorella trifurcata. One of the new metabolites isolated, 7α-acetoxy-9-epi-13β-hydroxymulinane, possesses a new trans-syn-trans arrangement in a
Anne M Hanneken et al.
Investigative ophthalmology & visual science, 54(2), 1485-1489 (2013-01-24)
Visual hallucinations (VHs) occur in macular degeneration patients with poor vision but normal cognitive function. The underlying mechanisms are poorly understood. We report the identification of pharmaceutical agents that enhance VH and use these agents to examine the contribution of
Jong Sun Kim et al.
Gut and liver, 8(5), 480-486 (2014-09-18)
Many authors recommend performing a second-look endoscopy (SLE) to reduce the frequency of delayed bleeding after endoscopic submucosal dissection (ESD) for gastric neoplasms, but these recommendations have been made despite a lack of reliable evidence supporting the effectiveness of SLE.
Sungmo Jung et al.
Journal of gastroenterology and hepatology, 30(1), 75-81 (2014-08-05)
Metachronous recurrence often occurs after endoscopic submucosal dissection for early gastric cancer, and a method for preventing recurrence is unknown. We aimed to identify risk factors for metachronous lesions, and the effects of aspirin use and Helicobacter pylori eradication on
Rohan K Mahabaleshwarkar et al.
Current medical research and opinion, 29(4), 315-323 (2013-02-01)
To examine the effect of concomitant use of clopidogrel and PPIs in a national sample of elderly Medicare beneficiaries (age ≥65 years). A nested case-control design was employed. A cohort of Medicare beneficiaries who initiated clopidogrel and did not have
Karin Becker et al.
Pharmaceutical research, 32(5), 1519-1545 (2015-03-20)
Lipid excipients are applied for numerous purposes such as taste masking, controlled release, improvement of swallowability and moisture protection. Several melting techniques have evolved in the last decades. Common examples are melt coating, melt granulation and melt extrusion. The required
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