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Iris J Gonzalez-Leal et al.
PLoS neglected tropical diseases, 8(9), e3194-e3194 (2014-09-26)
Resistance and susceptibility to Leishmania major infection in the murine model is determined by the capacity of the host to mount either a protective Th1 response or a Th2 response associated with disease progression. Previous reports involving the use of
Mingcan Xia et al.
The Journal of allergy and clinical immunology, 134(3), 634-644 (2014-04-29)
CCR10 and CCL27 make up the most skin-specific chemokine receptor/ligand pair implicated in skin allergy and inflammatory diseases, including atopic dermatitis and psoriasis. This pair is thought to regulate the migration, maintenance, or both of skin T cells and is
Barbara Blouw et al.
PloS one, 10(3), e0121003-e0121003 (2015-04-01)
The ability of cancer cells to invade underlies metastatic progression. One mechanism by which cancer cells can become invasive is through the formation of structures called invadopodia, which are dynamic, actin-rich membrane protrusions that are sites of focal extracellular matrix
Mikael Altun et al.
PloS one, 10(1), e0115344-e0115344 (2015-01-16)
Ovarian tumor domain containing proteases cleave ubiquitin (Ub) and ubiquitin-like polypeptides from proteins. Here we report the crystal structure of human otubain 2 (OTUB2) in complex with a ubiquitin-based covalent inhibitor, Ub-Br2. The ubiquitin binding mode is oriented differently to
Masaya Yamaguchi et al.
Journal of molecular biology, 427(8), 1748-1764 (2014-12-10)
The anaphase-promoting complex/cyclosome (APC/C) is a massive E3 ligase that controls mitosis by catalyzing ubiquitination of key cell cycle regulatory proteins. The APC/C assembly contains two subcomplexes: the "Platform" centers around a cullin-RING-like E3 ligase catalytic core; the "Arc Lamp"
Yongwoo Jang et al.
Pflugers Archiv : European journal of physiology, 466(10), 1987-1998 (2014-01-15)
Intracellular Ca(2+) signal is a key regulator of axonal growth during brain development. As transient receptor potential (TRP) channels are permeable to Ca(2+) and mediate numerous brain functions, it is conceivable that many TRP channels would regulate neuronal differentiation. We
Jaime Belkind-Gerson et al.
Inflammatory bowel diseases, 21(4), 870-878 (2015-03-06)
The intestine is known to contain enteric neuronal progenitors, but their precise identity and the mechanisms that activate them remain unknown. Based on the evidence for the neurogenic role of serotonin (5-HT) in the postnatal gut and the observation of
Kalpana Mandal et al.
Nature communications, 5, 5749-5749 (2014-12-11)
Cells sense and respond to their mechanical environment by exerting forces on their surroundings. The way forces are modulated by extra-cellular matrix (ECM) properties plays a key role in tissue homoeostasis. Using highly resolved micropatterns that constrain cells into the
Joseph C Gerding et al.
Veterinary ophthalmology, 17 Suppl 1, 97-106 (2014-04-02)
To review the clinical features, treatments, complications, and outcomes of horses with traumatic orbital fractures. Retrospective study. Eighteen horses with confirmed orbital fractures. Medical records of horses presenting with orbital fractures between 2006 and 2013 were reviewed. Signalment, etiology of
Cammi N Valdez et al.
The American journal of pathology, 184(10), 2618-2626 (2014-08-06)
Diabetes can lead to vision loss because of progressive degeneration of the neurovascular unit in the retina, a condition known as diabetic retinopathy. In its early stages, the pathology is characterized by microangiopathies, including microaneurysms, microhemorrhages, and nerve layer infarcts
Liana R Stein et al.
The EMBO journal, 33(12), 1321-1340 (2014-05-09)
Neural stem/progenitor cell (NSPC) proliferation and self-renewal, as well as insult-induced differentiation, decrease markedly with age. The molecular mechanisms responsible for these declines remain unclear. Here, we show that levels of NAD(+) and nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in
Hany Elmekawey et al.
Journal of glaucoma, 23(7), 437-440 (2013-05-02)
The purpose of this study is to evaluate the efficacy of intracameral ranibizumab (ICR) injections with subsequent mitomycin C (MMC) augmented trabeculectomy in the management of neovascular glaucoma (NVG). This is a prospective, interventional study of NVG, with research conducted
Lee-Wei Chen et al.
Journal of the American College of Surgeons, 219(4), 606-619 (2014-09-23)
Burn patients can incur high rates of hospital-acquired infections. The mechanism of antibiotic exposure on inducing infection vulnerability has not been determined. This study aimed to examine the effects of antibiotic treatment on host defense mechanisms. First we treated C57/BL6
Eunseok Seo et al.
Microvascular research, 98, 172-182 (2014-02-19)
A bio-inspired in vitro disease model was developed to investigate the basic biophysics of atherosclerotic diseases. In vivo study was conducted in advance using zebrafish fed with a normal diet and a cholesterol-enriched diet. The endothelial cells (ECs) of the
Marcio Jose Ferreira et al.
Toxicon : official journal of the International Society on Toxinology, 87, 54-67 (2014-06-03)
Here we evaluated whether Natterins affect the leukocyte-endothelial cell interaction, hampering leukocyte mobilization and extravasation. Leukocyte-endothelial cell interactions were evaluated in venules of mouse cremaster muscle using intravital microscopy. We reported that low doses of Natterins interfere with the cell
Jingjing Qi et al.
PloS one, 9(5), e98052-e98052 (2014-05-23)
Receptor-like protein tyrosine phosphatases (RPTPs) are type I transmembrane glycoproteins with N-glycans whose catalytic activities are regulated by dimerization. However, the intrinsic mechanism involved in dimerizing processes remains obscure. In this study, receptor protein tyrosine phosphatase rho (PTPRT) is identified
Cora Sin et al.
Journal of molecular neuroscience : MN, 55(2), 437-448 (2014-07-17)
FOXP1, FOXP2, and FOXP4 are three members of the FOXP gene subfamily of transcription factors involved in the development of the central nervous system. Previous studies have shown that the transcriptional activity of FOXP1/2/4 is regulated by homo- and heterodimerization.
Akiko Motoyoshi-Yamashiro et al.
The Journal of veterinary medical science, 76(10), 1353-1358 (2014-10-07)
Amphotericin B (AmB) is a polyene antifungal drug and is reported to be one of a few reagents having therapeutic effects on prion diseases, that is, a delay in the appearance of clinical signs and prolongation of the survival time
Tsukasa Kitahashi et al.
Pancreas, 44(1), 76-86 (2014-07-19)
The aim of the present study was to characterize molecular targets for the prevention/diagnosis of pancreatic cancer using a chemically induced hamster pancreatic carcinogenesis model, in which background injuries to the parenchyma, for example, chronic pancreatitis or acinar atrophy, are
Yuka Okura et al.
Journal of clinical immunology, 35(2), 158-167 (2015-02-11)
Chronic granulomatous disease (CGD) is a primary immunodeficiency disease that is characterized by susceptibility to bacterial and fungal infections. Various mutations in CYBB encoding the gp91(phox) subunit of the phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase impair the respiratory burst
Yi-Da Wang et al.
Fish & shellfish immunology, 42(1), 121-131 (2014-12-03)
Nervous necrosis virus (NNV) infects a wide range of larval and juvenile fish species, thereby causing enormous economic losses in the aquaculture industry. Possible solutions to this problem include the use of antimicrobial peptides (AMPs), which directly inhibit bacterial growth
Ying Deng et al.
Biochemical and biophysical research communications, 458(2), 321-327 (2015-02-07)
Single nucleotide polymorphism (SNP) rs11671784 is in the loop of pre-miR-27a and the G/A variation can significantly decrease mature miR-27a expression. This study explored the role of miR-27a in chemo-sensitivity of bladder cancer and how rs11671784 G/A variation affects the
Hsiao-Ling Chen et al.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 27(5), 1057-1068 (2014-05-21)
This study investigated the ability of aerosolized bovine lactoferrin (bLF) to protect the lungs from injury induced by chronic hyperoxia. Female CD-1 mice were exposed to hyperoxia (FiO2 = 80 %) for 7 days to induce lung injury and fibrosis. The therapeutic effects of
Tomio Yabe et al.
Analytical biochemistry, 472, 1-6 (2014-12-03)
We previously identified a peptide heparin-associated peptide Y (HappY) that binds specifically to heparin. In this article, we report a novel heparin detection system using chemically modified HappY as a probe. The photoreactive HappY probe was serially diluted and dispensed
N Maugeri et al.
Journal of thrombosis and haemostasis : JTH, 12(12), 2074-2088 (2014-08-29)
Increasing evidence implicates both platelets and neutrophils in the formation, stabilization, and growth of peripheral and coronary thrombi. Neutrophil extracellular traps (NETs) play a key role. The early events in the deregulated cross-talk between platelets and neutrophils are poorly characterized.
Pramod K Gupta et al.
Bioconjugate chemistry, 25(6), 1091-1102 (2014-05-21)
We have designed lectin functionalized Lipo-polymerosome bearing Amphotericin B (Lec-AmB-L-Psome) for specific internalization via lectin receptors overexpressed on infected macrophages of mononuclear phagocytic system (MPS) for the effective management of intramacrophage diseases such as visceral leishmaniasis. The lipo-polymerosome composed of
Lintao Zhao et al.
Cellular immunology, 293(2), 130-136 (2015-01-27)
TNF-alpha plays an important role in the development of secondary lymphoid tissues. Earlier studies showed that fibroblastic reticular cells express TNF-alpha receptor, suggesting that TNF-alpha may affect the development of FRCs. To test this, we analyzed the development and function
Maria Adriana Skeff et al.
PloS one, 9(12), e113378-e113378 (2014-12-06)
Mucositis induced by anti-neoplastic drugs is an important, dose-limiting and costly side-effect of cancer therapy. To evaluate the effect of the topical application of S-nitrosoglutathione (GSNO), a nitric oxide donor, on 5-fluorouracil (5-FU)-induced oral mucositis in hamsters. Oral mucositis was
Zahra Bateni et al.
Systems biology in reproductive medicine, 60(4), 245-250 (2014-04-08)
Despite extensive research carried out for optimization and commercialization of sperm cryopreservation media, percentage of motility and viability remain low following cryopreservation. These adverse effects have been partially ascribed to reactive oxygen species (ROS) production during cryopreservation. Therefore, we proposed
Zhongliang Ma et al.
Oncology reports, 32(5), 2111-2117 (2014-09-02)
Isatin is an endogenous indole in mammalian tissues and fluids that is expected to have antitumor effects in human breast cancer cells. Human breast cancer cells (MCF-7) were exposed to isatin at various concentrations (0, 50, 100, 200 µmol/l) for 48 h.
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