Y0001259

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Central V1b receptor antagonism in lactating rats: impairment of maternal care but not of maternal aggression.

D S Bayerl et al.

Journal of neuroendocrinology, 26(12), 918-926 (2014-10-07)

Maternal behaviour in rodents is mediated by the central oxytocin and vasopressin systems, amongst others. The role of vasopressin, acting via the V1a receptor (V1aR), on maternal care and maternal aggression has recently been described. However, a potential involvement of the

Catabolic signaling and muscle wasting after acute ischemic stroke in mice: indication for a stroke-specific sarcopenia.

Jochen Springer et al.

Stroke, 45(12), 3675-3683 (2014-10-30)

Muscle wasting is a common complication accompanying stroke. Although it is known to impair poststroke recovery, the mechanisms of subacute catabolism after stroke have not been investigated in detail. The aim of this study is to investigate mechanisms of local

Consumption of ground beef obtained from cattle that had received steroidal growth promotants does not trigger early onset of estrus in prepubertal pigs.

James D Magolski et al.

The Journal of nutrition, 144(11), 1718-1724 (2014-10-22)

The earlier onset of puberty seen in young American girls has led researchers to question if a causal relation exists between dietary sources of estrogenic compounds and precocious puberty. Using the prepubertal gilt (young female pig) as an animal model

Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia.

Yu Bin Ho et al.

The Science of the total environment, 488-489, 261-267 (2014-05-20)

Repeated applications of animal manure as fertilizer are normal agricultural practices that may release veterinary antibiotics and hormones into the environment from treated animals. Broiler manure samples and their respective manure-amended agricultural soil samples were collected in selected locations in

First- and second-generation quinolone antibacterial drugs interacting with zinc(II): structure and biological perspectives.

Alketa Tarushi et al.

Journal of inorganic biochemistry, 121, 53-65 (2013-01-29)

Interaction of equimolar quantities of ZnCl2 with the quinolone antibacterial drugs flumequine (Hflmq), oxolinic acid (Hoxo) or enrofloxacin (Herx) and the N,N'-donor heterocyclic ligands 1,10-phenanthroline (phen) or 2,2'-bipyridine (bipy) results in the formation of 1:1 drug to metal complexes with

Abscesses associated with a Brucella inopinata-like bacterium in a big-eyed tree frog (Leptopelis vermiculatus).

Dominik Fischer et al.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 43(3), 625-628 (2012-10-23)

A 4-yr-old big-eyed tree frog (Leptopelis vermiculatus) was submitted with two pea-sized (4-mm diameter), firm, and painful masses on the right side of its back. The two abscess-like masses were surgically opened, and a whitish-yellow pasty content was removed. A

The development and validation of a rapid method for the determination of antimicrobial agent residues in milk and meat using ultra performance liquid chromatography coupled to quadrupole--Orbitrap mass spectrometry.

Guntis Cepurnieks et al.

Journal of pharmaceutical and biomedical analysis, 102, 184-192 (2014-10-06)

A new multi-class method has been developed for the identification and quantification of the residues of 26 antibiotics from different classes (sulfonamides, macrolides, tetracyclines, penicillins, and quinolones) in milk and meat by ultra performance liquid chromatography coupled to hybrid quadrupole

FAAH-mediated modulation of TLR3-induced neuroinflammation in the rat hippocampus.

Rebecca J Henry et al.

Journal of neuroimmunology, 276(1-2), 126-134 (2014-09-24)

The present study examined the effect of enhancing fatty acid amide hydrolase (FAAH) substrate levels in vivo on Toll-like receptor (TLR)3-induced neuroinflammation. Systemic and central (i.c.v.) administration of the FAAH inhibitor URB597 increased hippocampal levels of the N-acylethanolamines palmitoylethanolamide and

Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines.

Kyoung won Seo et al.

PloS one, 7(8), e42960-e42960 (2012-08-29)

Despite significant advancements in osteosarcoma research, the overall survival of canine and human osteosarcoma patients has remained essentially static over the past 2 decades. Post-operative limb-spare infection has been associated with improved survival in both species, yet a mechanism for

Production and characterization of a monoclonal antibody against enrofloxacin.

Manaspong Chusri et al.

Journal of microbiology and biotechnology, 23(1), 69-75 (2013-01-15)

Enrofloxacin is a fluoroquinolone antibiotic approved for the treatment of infections in animals. Because of the side effects to consumers of animal products, the maximum residue limits (MRLs) of enrofloxacin in animal tissues for consumption are regulated. In this study

A toll-like receptor 9 antagonist improves bladder function and white matter sparing in spinal cord injury.

Brian T David et al.

Journal of neurotrauma, 31(21), 1800-1806 (2014-06-18)

Spinal cord injury (SCI) affects motor, sensory, and autonomic functions. As current therapies do not adequately alleviate functional deficits, the development of new and more effective approaches is of critical importance. Our earlier investigations indicated that intrathecal administration of a

An autologously generated platelet-rich plasma suturable membrane may enhance peripheral nerve regeneration after neurorraphy in an acute injury model of sciatic nerve neurotmesis.

Elisabetta Giannessi et al.

Journal of reconstructive microsurgery, 30(9), 617-626 (2014-05-20)

The aim of this study was to investigate the ability of suturable platelet-rich plasma (PRP) membrane to promote peripheral nerve regeneration after neurotmesis and neurorraphy. A total of 36 rats were used: 32 animals underwent surgery and were split in

Suspected seminal vesiculitis in an Asian elephant (Elephas maximus).

Jennifer J Kilburn et al.

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians, 42(3), 485-489 (2012-09-07)

A 32-year-old male Asian elephant (Elephas maximus) underwent routine transrectal stimulation for semen collection as part of an artificial insemination program. The procedure consisted of a preinsemination semen collection followed by two consecutive days of semen collections for artificial insemination.

Stimulus-timing-dependent modifications of rate-level functions in animals with and without tinnitus.

Roxana A Stefanescu et al.

Journal of neurophysiology, 113(3), 956-970 (2014-11-14)

Tinnitus has been associated with enhanced central gain manifested by increased spontaneous activity and sound-evoked firing rates of principal neurons at various stations of the auditory pathway. Yet, the mechanisms leading to these modifications are not well understood. In a

Isolation of Escherichia coli strains with AcrAB-TolC efflux pump-associated intermediate interpretation or resistance to fluoroquinolone, chloramphenicol and aminopenicillin from dogs admitted to a university veterinary hospital.

Toyotaka Sato et al.

The Journal of veterinary medical science, 76(7), 937-945 (2014-03-22)

Understanding the prevalence of antimicrobial-resistance and the relationship between emergence of resistant bacteria and clinical treatment can facilitate design of effective treatment strategies. We here examined antimicrobial susceptibilities of Escherichia coli isolated from dogs admitted to a university hospital (University

Comparison of different advanced oxidation processes for the degradation of two fluoroquinolone antibiotics in aqueous solutions.

Maria Bobu et al.

Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 48(3), 251-262 (2012-12-19)

In this study a comparative assessment using various advanced oxidation processes (UV/H(2)O(2), UV/H(2)O(2)/Fe(II), O(3), O(3)/UV, O(3)/UV/H(2)O(2) and O(3)/UV/H(2)O(2)/Fe(II)) was attempted to degrade efficiently two fluoroquinolone drugs ENR [enrofloxacin (1-Cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolonecarboxylic acid)] and CIP [ciprofloxacin (1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-quinoline-3-carboxylic acid)] in aqueous solutions at a

High-performance thin-layer chromatography screening of multi class antibiotics in animal food by bioluminescent bioautography and electrospray ionization mass spectrometry.

Yisheng Chen et al.

Journal of chromatography. A, 1356, 249-257 (2014-07-13)

The world-wide usage and partly abuse of veterinary antibiotics resulted in a pressing need to control residues in animal-derived foods. Large-scale screening for residues of antibiotics is typically performed by microbial agar diffusion tests. This work employing high-performance thin-layer chromatography

Growth and metastasis of B16-F10 melanoma cells is not critically dependent on host CD73 expression in mice.

Sandra Burghoff et al.

BMC cancer, 14, 898-898 (2014-12-04)

Recent studies have suggested that adenosine generated by ecto-5'-nucleotidase (CD73) in the tumor microenvironment plays a major role in promoting tumor growth by suppressing the immune response and stimulating angiogenesis via A2A and A2B receptors. However, adenosine has also been

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain.

Debbie Le Blon et al.

Immunology and cell biology, 92(8), 650-658 (2014-07-02)

Although implantation of cellular material in the central nervous system (CNS) is a key direction in CNS regenerative medicine, this approach is currently limited by the occurrence of strong endogenous immune cell responses. In a model of mesenchymal stem cell

Concurrent access to nicotine and sucrose in rats.

Leigh V Panlilio et al.

Psychopharmacology, 232(8), 1451-1460 (2014-11-05)

Animal models that allow concurrent access to drug and nondrug reinforcers provide unique insight into the etiology, maintenance, and treatment of drug use. We sought to develop and utilize a concurrent access procedure with nicotine and sucrose in rats. Pressing

Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.

Diego G Rocha et al.

Journal of chromatography. A, 1379, 83-91 (2015-01-13)

This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and kidney: ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, flumequine, marbofloxacin, nalidixic acid, norfloxacin, ofloxacin, oxolinic acid

Accumulation and elimination of enrofloxacin and its metabolite ciprofloxacin in the ridgetail white prawn Exopalaemon carinicauda following medicated feed and bath administration.

J P Liang et al.

Journal of veterinary pharmacology and therapeutics, 37(5), 508-514 (2014-03-13)

Accumulation and elimination of enrofloxacin and its metabolite ciprofloxacin were evaluated in Exopalaemon carinicauda following medicated feed at dose of 10 mg/kg weight body per day for five consecutive days and 10 mg/L bath for five consecutive days at 18 °C. At different

Cobalt(II) complexes with the antimicrobial drug enrofloxacin: structure, antimicrobial activity, DNA- and albumin-binding.

Catherine Protogeraki et al.

European journal of medicinal chemistry, 86, 189-201 (2014-08-26)

The cobalt(II) complexes with the quinolone antimicrobial agent enrofloxacin (Herx) in the presence of the nitrogen-donor heterocyclic ligands pyridine (py), 2,2'-bipyridylamine (bipyam), 1,10-phenanthroline (phen), 2,2'-bipyridine (bipy) or the oxygen-donor ligand N,N-dimethylformamide (DMF) were synthesized and characterized. The crystal structures of

In vitro selection of RNA aptamers that selectively bind danofloxacin.

Seung Ryul Han et al.

Biochemical and biophysical research communications, 448(4), 397-402 (2014-05-06)

Danofloxacin is a synthetic fluoroquinolone with broad spectrum antibacterial activity that is used for the treatment of respiratory diseases in animal husbandry. However, danofloxacin has many adverse reactions and is toxic to humans. Especially, it detrimentally affects muscle, central nerve

The effect of breed and sex on sulfamethazine, enrofloxacin, fenbendazole and flunixin meglumine pharmacokinetic parameters in swine.

J T Howard et al.

Journal of veterinary pharmacology and therapeutics, 37(6), 531-541 (2014-04-16)

Drug use in livestock has received increased attention due to welfare concerns and food safety. Characterizing heterogeneity in the way swine populations respond to drugs could allow for group-specific dose or drug recommendations. Our objective was to determine whether drug

Lysozyme-triggered epidermal growth factor release from bacterial cellulose membranes controlled by smart nanostructured films.

Guilherme Fadel Picheth et al.

Journal of pharmaceutical sciences, 103(12), 3958-3965 (2014-10-14)

A novel wound-dressing biodevice, sensitive to lysozyme, an enzyme commonly found at infected skin wounds, was assembled by the layer-by-layer deposition of nanopolymeric chitosan and alginate films onto oxidized bacterial cellulose membranes incorporated with epidermal growth factor (EGF). Distinct EGF

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis.

Michael J Flister et al.

Circulation. Cardiovascular genetics, 8(2), 294-304 (2015-01-30)

Genome-wide association studies are powerful tools for nominating pathogenic variants, but offer little insight as to how candidate genes affect disease outcome. Such is the case for SH2B adaptor protein 3 (SH2B3), which is a negative regulator of multiple cytokine

Social preference and maternal defeat-induced social avoidance in virgin female rats: sex differences in involvement of brain oxytocin and vasopressin.

Michael Lukas et al.

Journal of neuroscience methods, 234, 101-107 (2014-04-09)

Research concerning non-reproductive sociability in rodents is mainly restricted to assessing the effects of oxytocin (OXT) and arginine-vasopressin (AVP) in male rats and mice. Comparable studies on natural social preference and social avoidance in females are substantially lacking. Here, we

Gastric vagal motoneuron function is maintained following experimental spinal cord injury.

E M Swartz et al.

Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 26(12), 1717-1729 (2014-10-16)

Clinical reports indicate that spinal cord injury (SCI) initiates profound gastric dysfunction. Gastric reflexes involve stimulation of sensory vagal fibers, which engage brainstem circuits that modulate efferent output back to the stomach, thereby completing the vago-vagal reflex. Our recent studies

Three-dimensional printing of rhBMP-2-loaded scaffolds with long-term delivery for enhanced bone regeneration in a rabbit diaphyseal defect.

Jin-Hyung Shim et al.

Tissue engineering. Part A, 20(13-14), 1980-1992 (2014-02-13)

In this study, recombinant human bone morphogenetic protein-2 (rhBMP-2) delivery system with slow mode was successfully developed in three-dimensional (3D) printing-based polycaprolactone (PCL)/poly(lactic-co-glycolic acid) (PLGA) scaffolds for bone formation of critical-sized rabbit segmental diaphyseal defect. To control the delivery of

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