- Asymmetric synthesis of spiro-3,4-dihydropyrans via a domino organocatalytic sequence.
Asymmetric synthesis of spiro-3,4-dihydropyrans via a domino organocatalytic sequence.
Organic letters (2010-05-01)
Weijun Yao, Lianjie Pan, Yihua Wu, Cheng Ma
PMID20429598
摘要
A cinchona alkaloid-catalyzed domino Michael/hemiacetalization reaction of cyclic beta-oxo aldehydes and aromatic beta,gamma-unsaturated alpha-keto esters, resulting in the formation of spiro-dihydropyran architectures in good yield with high stereoselectivity (up to 97% ee), is presented.
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