Merck
CN

CHRNA4

cholinergic receptor, nicotinic, alpha 4 (neuronal)

别名:
BFNC, EBN, EBN1, NACHR, NACHRA4, NACRA4
物种:
UniProtKB ID:
基因ID:
  • Human(1137) Summary: This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
  • Mouse(11438) cholinergic receptor, nicotinic, alpha polypeptide 4
  • Rat(25590) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • chicken(395606) cholinergic receptor, nicotinic, alpha 4
  • Domestic Rabbit(100345481) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • sheep(101118889) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • naked mole-rat(101714448) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • domestic guinea pig(100716877) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • cow(537251) cholinergic receptor, nicotinic, alpha 4
  • Zebrafish(556619) cholinergic receptor, nicotinic, alpha 4
  • Horse(100146784) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • domestic cat(101101300) cholinergic receptor, nicotinic, alpha 4 (neuronal)
  • dog(485972) cholinergic receptor, nicotinic, alpha 4 (neuronal)

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

货号
说明
物种
卡巴胆碱, ≥98% (titration), crystalline,
物种
human, mouse, rat
十烃溴铵, crystalline,
物种
human
1,1-二甲基-4-苯基哌嗪碘化物, ≥98% (TLC or titration),
物种
human, rat

Small Molecule - Antagonist

货号
说明
物种
卡巴胆碱, ≥98% (titration), crystalline,
物种
human, mouse, rat
美加明 盐酸盐, ,
物种
human
1,1-二甲基-4-苯基哌嗪碘化物, ≥98% (TLC or titration),
物种
human, rat
犬尿喹啉酸, ≥98%,
物种
rat, human

Antibodies

货号
说明
物种反应性
应用
Anti-Nicotinic Acetylcholine Receptor α4 Antibody, from rabbit, purified by affinity chromatography,
物种反应性
human, mouse, rat
应用
western blot
Anti-nAChR α4 Subunit Antibody, clone 369, clone 369, from mouse,
物种反应性
human, monkey, rabbit
应用
immunofluorescence
immunohistochemistry
Anti-ACHA4 antibody produced in rabbit, ,
物种反应性
human, mouse, rat
应用
immunohistochemistry
western blot
Anti-CHRNA4 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
物种反应性
human
应用
western blot

Small Molecule - Blocker

货号
说明
物种
四乙基氯化铵, ≥98% (titration),
物种
human
溴化已烷双胺, ,
物种
human
氯化六甲铵, solid (hygroscopic),
物种
human
犬尿喹啉酸, ≥98%,
物种
rat, human