Merck
CN

TOP2A

topoisomerase (DNA) II alpha 170kDa

别名:
TOP2, TP2A
物种:
Human TOP2A (7153), Mouse Top2a (21973), Rat Top2a (360243), dog TOP2A (480525), Domestic Rabbit TOP2A (100357676), Zebrafish top2a (323733), chicken TOP2A (395570), sheep TOP2A (101108762), domestic guinea pig Top2a (100730168), cow TOP2A (787696)
UniProtKB ID:
P11388, B2RTS1, Q71UN1, Q71UQ5, Q9HB24, Q9HB25, Q9HB26, Q9UP44
基因ID:
  • Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
  • Mouse(21973) topoisomerase (DNA) II alpha
  • Rat(360243) topoisomerase (DNA) II alpha
  • dog(480525) topoisomerase (DNA) II alpha 170kDa
  • Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
  • Zebrafish(323733) topoisomerase (DNA) II alpha
  • chicken(395570) topoisomerase (DNA) II alpha 170kDa
  • sheep(101108762) topoisomerase (DNA) II alpha 170kDa
  • domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
  • cow(787696) topoisomerase (DNA) II alpha 170kDa
  • domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa

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Antibodies

货号
说明
物种反应性
应用
HPA006458
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
物种反应性
human
应用
immunohistochemistry
western blot
ZRB2034
Anti-Topoisomerase II Antibody, clone 3C3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse
应用
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
SAB4502997
Anti-TOP2A, antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
immunohistochemistry
western blot
HPA026773
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
物种反应性
human
应用
immunohistochemistry
SAB4502996
Anti-TOP2A antibody produced in rabbit, affinity isolated antibody,
物种反应性
human
应用
ELISA
western blot

Small Molecule - Inhibitor

货号
说明
物种
M6545
米托蒽醌 二盐酸盐, ≥97% (HPLC),
物种
human
D8809
柔红霉素 盐酸盐, meets USP testing specifications,
物种
human
D1515
阿霉素 盐酸盐, 98.0-102.0% (HPLC),
物种
human
M2305000
米托蒽醌 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human
1445200
米托蒽醌 二盐酸盐, United States Pharmacopeia (USP) Reference Standard,
物种
human

Proteins

货号
说明
物种
T8944
拓扑异构酶 Ⅱα 人, (Single band on SDS-PAGE), liquid,
物种
human

esiRNA

货号
说明
物种
EMU058411
MISSION® esiRNA, targeting mouse Top2a,
物种
mouse
EHU073241
MISSION® esiRNA, targeting human TOP2A,
物种
human