Merck
CN

GRM3

glutamate receptor, metabotropic 3

别名:
GLUR3, GPRC1C, MGLUR3, mGlu3
物种:
UniProtKB ID:
基因ID:
  • Human(2913) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
  • Mouse(108069) glutamate receptor, metabotropic 3
  • Rat(24416) glutamate receptor, metabotropic 3
  • domestic guinea pig(100731837) glutamate receptor, metabotropic 3
  • naked mole-rat(101713039) glutamate receptor, metabotropic 3
  • Zebrafish(565256) glutamate receptor, metabotropic 3
  • sheep(101113057) glutamate receptor, metabotropic 3
  • dog(100683236) glutamate receptor, metabotropic 3
  • Horse(100049918) glutamate receptor, metabotropic 3
  • domestic cat(101095810) glutamate receptor, metabotropic 3
  • cow(541056) glutamate receptor, metabotropic 3
  • chicken(418644) glutamate receptor, metabotropic 3

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Small Molecule - Agonist

货号
说明
物种
反式-(±)-ACPD 一水合物, solid, ≥97% (NMR),
物种
human
L-(+)-2-氨基-4-膦酰基丁酸, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
物种
rat, human
L-谷氨酸, ReagentPlus®, ≥99% (HPLC),
物种
rat, human
L-谷氨酸, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
物种
rat, human
L-谷氨酸, BioUltra, ≥99.5% (NT),
物种
rat, human

Small Molecule - Antagonist

货号
说明
物种
(±)-α-Methyl-(4-carboxyphenyl)glycine, ,
物种
human, rat
DL-2-Amino-3-phosphonopropionic acid, ,
物种
human
L-谷氨酸, ReagentPlus®, ≥99% (HPLC),
物种
rat, human
L-谷氨酸, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
物种
rat, human
L-谷氨酸, BioUltra, ≥99.5% (NT),
物种
rat, human

Small Molecule - Mixed Agonist/Antagonist

货号
说明
物种
(±)-α-Methyl-(4-carboxyphenyl)glycine, ,
物种
human, rat
L-(+)-2-氨基-4-膦酰基丁酸, optical purity optical purity: ≥95% (HPLC, Marfey′s reagent),
物种
rat, human
L-谷氨酸, ReagentPlus®, ≥99% (HPLC),
物种
rat, human
L-谷氨酸, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%,
物种
rat, human
L-谷氨酸, BioUltra, ≥99.5% (NT),
物种
rat, human

esiRNA

货号
说明
物种
MISSION® esiRNA, targeting human GRM3,
物种
human