HPA003575

抗-TRIM22 兔抗

Name: 抗-TRIM22 兔抗
Brand: SIGMA

Ab2, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

别名:

抗-50 kDa刺激的反式作用因子兔抗, 抗-RING指蛋白94 兔抗, 抗-Staf-50 兔抗, 抗-含三结构域蛋白的蛋白质22 兔抗

登录查看组织和合同定价。

选择尺寸

关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

Human Protein Atlas Number:

HPA003575

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, IHC

Citations:

主要文件

查看所有文档

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies^® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

enhanced validation

RNAi knockdown
Learn more about Antibody Enhanced Validation

technique(s)

immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:500-1:1000

immunogen sequence

NEVVKECQEKLQVALQRLIKEDQEAEKLEDDIRQERTAWKNYIQIERQKILKGFNEMRVILDNEEQRELQKLEEGEVNVLDNLAAATDQLVQQRQDASTLISDLQRRLRGSSVEMLQDVIDVMKRSESWTLKKPKSVSKKLKSVFRV

UniProt accession no.

Q8IYM9

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... TRIM22(10346)

正在寻找类似产品? 访问产品对比指南

Immunogen

三结构域蛋白22重组蛋白质表位信号标签（PrEST）

Application

成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）

Biochem/physiol Actions

三结构域蛋白22（tripartite motif-containing 22）是一种由人TRIM22基因编码的蛋白质，属于三结构域（tripartite motif ，TRIM）蛋白超家族。该家族的成员是针对病毒感染胡先天性免疫应答的重要效应因子。它是应干扰素（IFN）诱导蛋白，也是p⁵³靶基因。它通过限制病毒复制在病毒防御中起作用，并可作为泛素E3连接酶。该基因对于RNA 病毒（如乙肝病毒（HBV）、脑心肌炎病毒（ECMV）和人免疫缺陷病毒1型（HIV-1））具有抗病毒活性。它参与 NF-κB的活化。它可作为NF-κB介导的转录的正向调节剂。

Features and Benefits

Prestige抗体^®是经过高度表征和广泛验证的抗体，同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige抗体对其他蛋白质的独特性和低交叉反应性^®是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。针对每一个Prestige 抗体都存在有对应的Prestige抗原对照，并可在链接区域内找到。

每个Prestige 抗体都是按照以下方法进行测试的：

44例正常人类组织以及20例最常见癌症类型组织的IHC组织阵列。
364个人类重组蛋白片段的蛋白阵列。

Physical form

溶于磷酸盐缓冲盐水，pH 7.2，含有40%甘油和0.02%叠氮化钠

Other Notes

相应抗原APREST86655

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途，或人类或动物任何类型的消费或使用。

未找到合适的产品？

试试我们的产品选型工具.

存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

法规信息

常规特殊物品

低风险生物材料

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

A11983

R04091

R004091

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

miR-215 Enhances HCV Replication by Targeting TRIM22 and Inactivating NF-κB Signaling.

Hui Tian et al.

Yonsei medical journal, 59(4), 511-518 (2018-05-12)

Hepatitis C virus (HCV) infection is a major cause of liver disease. Several miRNAs have been found to be associated with HCV infection. This study aimed to investigate the functional roles and possible molecular mechanisms of miR-215 in HCV replication.

TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment.

Ravesh Singh et al.

Journal of virology, 88(8), 4291-4303 (2014-01-31)

The antiviral role of TRIM E3 ligases in vivo is not fully understood. To test the hypothesis that TRIM5α and TRIM22 have differential transcriptional regulation and distinct anti-HIV roles according to infection phase and compartment, we measured TRIM5α, TRIM22, and

Interferon-inducible TRIM22 contributes to maintenance of HIV-1 proviral latency in T cell lines.

Filippo Turrini et al.

Virus research, 269, 197631-197631 (2019-05-29)

The human immunodeficiency virus type-1 (HIV-1) establishes a state of latent infection in a small number of CD4+ T lymphocytes that, nonetheless, represent a major obstacle to viral eradication. We here show that Tripartite Motif-containing protein 22 (TRIM22), an epigenetic

Identification of tripartite motif-containing 22 (TRIM22) as a novel NF-κB activator.

Shanshan Yu et al.

Biochemical and biophysical research communications, 410(2), 247-251 (2011-06-10)

Increasing evidence suggests that TRIM family proteins may play important roles in the regulation of innate immune signaling pathways. Here we report TRIM22 is involved in the activation of NF-κB. It was found that overexpression of TRIM22 could dose-dependently activate

The human IFN-inducible p53 target gene TRIM22 colocalizes with the centrosome independently of cell cycle phase.

Jessica Petersson et al.

Experimental cell research, 316(4), 568-579 (2009-12-17)

TRIM22 (Staf50), a member of the TRIM protein family, is an interferon (IFN)-inducible protein as well as a p53 target gene. The function of TRIM22 is largely unknown, but TRIM22 is suggested to play a role in viral defense by

查看所有相关文献

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持

抗-TRIM22 兔抗

Ab2, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

选择尺寸

关于此项目

主要文件

属性

biological source

conjugate

antibody form

antibody product type

clone

product line

form

species reactivity

enhanced validation

technique(s)

immunogen sequence

UniProt accession no.

shipped in

storage temp.

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Immunogen

Application

Biochem/physiol Actions

Features and Benefits

Physical form

Other Notes

Legal Information

Disclaimer

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

法规信息

文件

分析证书(COA)

已有该产品？

同行评审论文

技术服务

Ab2, Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution