Merck
CN

APP

amyloid beta (A4) precursor protein

Synonyms:
AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
Species:
Human APP (351), Mouse App (11820), Rat App (54226), fruit fly app (39399), chicken APP (374198), dog APP (403407), domestic cat APP (101085564), cow APP (280722), sheep APP (101111593), domestic guinea pig App (100715302)
UniProtKB ID:
P05067, B2R5V1, B4DII8, D3DSD1, D3DSD2, D3DSD3, P09000, P78438
Gene ID:
  • Human(351) Summary: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(11820) amyloid beta (A4) precursor protein
  • Rat(54226) amyloid beta (A4) precursor protein
  • fruit fly(39399) approximated
  • chicken(374198) amyloid beta (A4) precursor protein
  • dog(403407) amyloid beta (A4) precursor protein
  • domestic cat(101085564) amyloid beta (A4) precursor protein
  • cow(280722) amyloid beta (A4) precursor protein
  • sheep(101111593) amyloid beta (A4) precursor protein
  • domestic guinea pig(100715302) amyloid beta (A4) precursor protein
  • naked mole-rat(101724743) amyloid beta (A4) precursor protein

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ELISA

Product Number
Description
Species
EZBRAIN42
Human Amyloid β42 Brain ELISA, This Human Amyloid β42 Brain ELISA is used to measure & quantify Amyloid β42 levels in Neuroscience research.,
Species
human
EZBRAIN-SET
Human Amyloid β40 and Amyloid β42 Brain ELISA, ,
Species
human
RAB0530
Human APP / Amyloid Beta A4 Protein ELISA Kit, for serum, plasma, cell culture supernatants and urine,
Species
human
EZHS
High Sensitivity Human Amyloid β40 and Amyloid β42 ELISA, ,
Species
human
EZHS40
High Sensitivity Human Amyloid β40 ELISA, This High Sensitivity Human Amyloid β40 ELISA is used to measure & quantify Amyloid β40 levels in Neuroscience research.,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
B9934
BTA-1, ≥98% (HPLC), solid,
Species
human
C1386
Curcumin, from Curcuma longa (Turmeric), powder,
Species
human
C7727
Curcumin, ≥94% (curcuminoid content), ≥80% (Curcumin),
Species
human
F8514
Flurbiprofen, cyclooxygenase inhibitor,
Species
human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
A8326
Anti-β-Amyloid Protein (1-40) antibody produced in rabbit, whole antiserum,
Species Reactivity
human
Application
ELISA
immunohistochemistry
ABN1665
Anti-Aβ-42 Antibody, oligomeric (VIA), from rabbit,
Species Reactivity
human
Application
dot blot
neutralization
western blot
MABN2297
Anti-APP Antibody, clone 7H6, clone 7H6, from rat,
Species Reactivity
human
Application
ELISA
flow cytometry
immunocytochemistry
immunoprecipitation (IP)
western blot
PC150
Anti-β-Amyloid (1-42) Rabbit pAb, liquid, Calbiochem®,
Species Reactivity
human
Application
AB9234
Anti-Amyloid Oligomer Antibody, αβ, oligomeric, serum, Chemicon®,
Species Reactivity
eukaryotes, human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot

Proteins

Product Number
Description
Species
A6933
Acetyl-Amyloid β-Protein Fragment 15-20 Amide, ≥97% (HPLC), powder,
Species
human
A2201
Amyloid β-Protein Fragment 35-25, ≥95% (HPLC),
Species
human
A0189
Amyloid β Protein Fragment 1-38, ≥95% (HPLC), powder,
Species
human
A5080
Amyloid β-Protein Fragment 22-35, ≥95% (HPLC),
Species
human
A4848
Amyloid β-Protein Fragment 17-40, ≥87% (HPLC), lyophilized powder,
Species
human

esiRNA

Product Number
Description
Species
EMU012021
MISSION® esiRNA, targeting mouse App,
Species
mouse
EHU085701
MISSION® esiRNA, targeting human APP,
Species
human