Merck
CN

CNR2

cannabinoid receptor 2 (macrophage)

Synonyms:
CB-2, CB2, CX5
Species:
Human CNR2 (1269), Mouse Cnr2 (12802), Rat Cnr2 (57302), chicken CNR2 (428232), Horse CNR2 (100071536), domestic cat CNR2 (101100234), dog CNR2 (612289), cow CNR2 (539769), sheep CNR2 (101119188), domestic guinea pig Cnr2 (100721528)
UniProtKB ID:
P34972, Q4VBK8, Q5JRH7, Q6B0G7, Q6NSY0
Gene ID:
  • Human(1269) Summary: The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008]
  • Mouse(12802) cannabinoid receptor 2 (macrophage)
  • Rat(57302) cannabinoid receptor 2 (macrophage)
  • chicken(428232) cannabinoid receptor 2 (macrophage)
  • Horse(100071536) cannabinoid receptor 2 (macrophage)
  • domestic cat(101100234) cannabinoid receptor 2 (macrophage)
  • dog(612289) cannabinoid receptor 2 (macrophage)
  • cow(539769) cannabinoid receptor 2 (macrophage)
  • sheep(101119188) cannabinoid receptor 2 (macrophage)
  • domestic guinea pig(100721528) cannabinoid receptor 2 (macrophage)
  • Zebrafish(795246) cannabinoid receptor 2

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Small Molecule - Agonist

Product Number
Description
Species
W102
(R)-(+)-WIN 55,212-2 mesylate salt, ≥98% (HPLC),
Species
human
A9719
Arachidonyl-2′-chloroethylamide hydrate, ≥97% (HPLC), oil,
Species
rat, mouse
O0383
N-Oleoylethanolamine, ~98% (TLC),
Species
human, mouse, rat

Small Molecule - Antagonist

Product Number
Description
Species
P5177
Methyl palmitate, ≥99% (capillary GC),
Species
human, rat
P0359
Palmitoylethanolamide, ,
Species
human, rat
A8973
2-Arachidonyl glycerol, ~10 mg/mL, ≥98% (HPLC),
Species
rat, human
A9719
Arachidonyl-2′-chloroethylamide hydrate, ≥97% (HPLC), oil,
Species
rat, mouse
A6226
AM251, >98% (HPLC), solid,
Species
mouse, rat

Antibodies

Product Number
Description
Species Reactivity
Application
WH0001269M1
Monoclonal Anti-CNR2 antibody produced in mouse, clone 3C7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
SAB4500346
Anti-CNR2 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
western blot
C1358
Anti-Cannabinoid Receptor 2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, rat
Application
immunocytochemistry
western blot

Small Molecule - Mixed Agonist/Antagonist

Product Number
Description
Species
C1112
CP-55940, >98% (HPLC), powder,
Species
human, rat
P0359
Palmitoylethanolamide, ,
Species
human, rat

esiRNA

Product Number
Description
Species
EHU120781
MISSION® esiRNA, targeting human CNR2,
Species
human