WH0001269M1
Monoclonal Anti-CNR2 antibody produced in mouse
clone 3C7, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-CB2, Anti-CX5, Anti-cannabinoid receptor 2 (macrophage)
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3C7, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
immunofluorescence: suitable
indirect ELISA: suitable
western blot: 1-5 μg/mL
isotype
IgG1κ
GenBank accession no.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CNR2(1269)
General description
Cannabinoid receptor 2 (CNR2) is encoded by the gene mapped to human chromosome 1p36.11. The encoded protein belongs to a novel cadherin-related multigene family. Members of this family contain six cadherin repeats and conserved DXNDNXPXF and DXD motifs with constitute putative calcium-binding sequences.
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. (provided by RefSeq)
Immunogen
CNR2 (NP_001832.1, 302 a.a. ~ 360 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Sequence
RSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
Application
Monoclonal Anti-CNR2 antibody produced in mouse has been used in western blot analysis.
Biochem/physiol Actions
Cannabinoid receptor 2 (CNR2) plays a crucial role in mediating anti-inflammatory and anti-atherosclerotic effects in vivo. It is also involved in cancer, bone metabolism and pain perception. CNR2 might be implicated in selective cell–cell interaction. Mutations in the gene has been associated with trochanter and hip bone mineral density (BMD).
Physical form
Solution in phosphate buffered saline, pH 7.4
Legal Information
GenBank is a registered trademark of United States Department of Health and Human Services
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Multiple osteoporosis susceptibility genes on chromosome 1p36 in Chinese.
Huang QY
Bone, 44, 984-988 (2009)
Sex-dependent influence of chronic mild stress (CMS) on voluntary alcohol consumption; study of neurobiological consequences
Marco EM, et al.
Pharmacology, Biochemistry, and Behavior, 152, 68-80 (2017)
Diversity Revealed by a Novel Family of Cadherins Expressed in Neurons at a Synaptic Complex
Kohmura N, et al.
Neuron, 20, 1137-1151 (1998)
Common polymorphisms in the cannabinoid CB2 receptor gene (CNR2) are not associated with myocardial infarction and cardiovascular risk factors.
Reinhard W, et al.
International Journal of Molecular Medicine, 22, 165-174 (2008)
Emerging therapeutic targets in cancer induced bone disease: A focus on the peripheral type 2 cannabinoid receptor.
Marino S and Idris A
Pharmacological Research, 119, 391-403 (2017)
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