CN
PTPRC
protein tyrosine phosphatase, receptor type, C
Synonyms:
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Species:
Human PTPRC (5788), Mouse Ptprc (19264), Rat Ptprc (24699), Zebrafish ptprc (559154), chicken PTPRC (386580), domestic cat PTPRC (101097123), Horse PTPRC (100061950), dog PTPRC (490255), sheep PTPRC (101102917), cow PTPRC (407152) ...More
UniProtKB ID:
Gene ID:
- Human(5788) Summary: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- Mouse(19264) protein tyrosine phosphatase, receptor type, C
- Rat(24699) protein tyrosine phosphatase, receptor type, C
- Zebrafish(559154) protein tyrosine phosphatase, receptor type, C
- chicken(386580) protein tyrosine phosphatase, receptor type, C
- domestic cat(101097123) protein tyrosine phosphatase, receptor type, C
- Horse(100061950) protein tyrosine phosphatase, receptor type, C
- dog(490255) protein tyrosine phosphatase, receptor type, C
- sheep(101102917) protein tyrosine phosphatase, receptor type, C
- cow(407152) protein tyrosine phosphatase, receptor type, C
- Domestic Rabbit(100358807) protein tyrosine phosphatase, receptor type, C
- naked mole-rat(101710515) protein tyrosine phosphatase, receptor type, C
- domestic guinea pig(100730564) protein tyrosine phosphatase, receptor type, C
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CD45RB-APC antibody produced in mouse, clone MEM-55, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human, nonhuman primates
Application
flow cytometry
Monoclonal Anti-CD45RA-Biotin antibody produced in mouse, clone MEM-56, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
Monoclonal Anti-CD45 antibody produced in rat, clone EM-05, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
mouse
Application
flow cytometry
Monoclonal Anti-CD45RA-APC antibody produced in mouse, clone MEM-56, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
Monoclonal Anti-CD45-FITC antibody produced in mouse, clone MEM-28, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
flow cytometry
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PTPRC (592-end), active, GST tagged from mouse, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
mouse
CD45 Active human, recombinant, expressed in baculovirus infected insect cells, ≥90% (SDS-PAGE),
Species
human
CD45 Protein, 10 µg, His6-tagged, recombinant, human CD45, amino acids 598-end, for use in Enzyme Assays.,
Species
human