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Synthetic Chemistry Learning Hub

Introduction

Synthetic chemistry drives innovation across drug development, materials science, and sustainable technologies by enabling complex molecule design. Advances in automation, AI, and green methods promise faster, more efficient, and eco-friendly synthesis, shaping the future of research and industry.

Advance your research with our Synthetic Chemistry Learning Center, your trusted hub for expert articles, protocols, product spotlights, and on-demand webinars. Explore the latest in synthetic methodologies, reaction optimization, process scale-up, and lab best practices to enhance your workflows. Whether you're looking to refine cross-coupling reactions, peptide synthesis, or photoredox catalysis, our curated resources help you stay at the forefront of synthetic chemistry innovations.

Featured Articles

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AdQPhos and Pd pre catalysts for alpha arylation reaction
AdQPhos and Pd pre catalysts for alpha arylation reaction
Discover AdQPhos and its Pd pre-catalysts for selective α-arylation of diverse nucleophiles under mild aqueous conditions without hazardous solvents.
Buchwald G6 Precatalysts: Oxidative Addition Complexes
Buchwald G6 Precatalysts: Oxidative Addition Complexes
Buchwald G6 precatalysts are oxidative addition complexes that are thermally, air, and moisture stable. The catalyst activation doesn’t require a base and generates innocuous byproducts.
Baran Diversinates™
Baran Diversinates™
Rapidly diversify (hetero)aromatic scaffolds for chemical industry needs amid resource and time constraints, ensuring efficiency.
PI & PSI–Chiral phosphorus incorporation harnessing the potential of P(V)
PI & PSI–Chiral phosphorus incorporation harnessing the potential of P(V)
PI and PSI reagents are a platform of phosphate-based reagents for phosphorylation and phosphothiolation of nucleotides and peptides developed by the Baran lab.
Fluorinated Azides: Click Chemistry Meets Fluorine
Fluorinated Azides: Click Chemistry Meets Fluorine
Fluorinated azides are a new tool that can be used to introduce fluorinated groups to molecules. These molecules can utilize click chemistry to easily add fluorinated groups.
The Role of High-Purity Metal Salts in Enhancing Chemical Synthesis
The Role of High-Purity Metal Salts in Enhancing Chemical Synthesis
Discover the ways in which high-purity metal salts improve the selectivity, yields, and catalytic efficacy of organic synthesis reactions.

Synthetic Chemistry Techniques & Technologies

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Peptide Synthesis
Peptide Synthesis
Peptide synthesis involves the formation of a peptide bond between two amino acids to create a peptide composed of a chain of multiple amino acids.
Synthetic Methods
Synthetic Methods
Explore our building blocks for cross-coupling, fluorination, metathesis, C-H functionalization, and photocatalysis for a complete organic reaction toolbox for small molecule synthesis methods.
Reaction Design & Optimization
Reaction Design & Optimization
Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.
Organic Reaction Toolbox
Organic Reaction Toolbox
An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.
ADC & Bioconjugation
ADC & Bioconjugation
Bioconjugation involves ligating molecules together in which at least one of the reactants is a biomolecule, often an antibody, protein, or oligonucleotide, for detection, assay, or targeting and tracking of the biomolecule.
Lead Discovery
Lead Discovery
Lead discovery or lead identification for drug discovery utilizes screening methods, such as high throughput screening (HTS) or DNA Encoded Library (DEL) screening, to identify lead compounds.

Resource Library

Recommended Reading

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Article: Peptide Coupling Reagents Selection Guide
Article: Peptide Coupling Reagents Selection Guide
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
Article: Buchwald Phosphine Ligands
Article: Buchwald Phosphine Ligands
Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.
Article: Crosslinkers Selection Guide
Article: Crosslinkers Selection Guide
Choosing the right crosslinker for your biochemical or bioconjugation research can be challenging. Our selection guide can help you find the perfect match for your applications.
Protocols for the Fmoc SPPS of Cysteine-Containing Peptides
Protocols for the Fmoc SPPS of Cysteine-Containing Peptides
Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.
Article: Potassium Organotrifluoroborates
Article: Potassium Organotrifluoroborates
Bench-stable Potassium Organotrifluoroborates enable diverse C-C bond formation reactions.
Article: Palladacycle Coupling Catalysts
Article: Palladacycle Coupling Catalysts
Palladacyclic catalysts by Bedford's group facilitate coupling reactions with low catalyst loadings and challenging aryl chlorides.

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Section Overview

Featured Articles
Synthetic Chemistry Techniques & Technologies
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