21860
CDI
≥97.0% (T), for peptide synthesis
Synonym(s):
1,1′-Carbonyldiimidazole
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About This Item
Empirical Formula (Hill Notation):
C7H6N4O
CAS Number:
Molecular Weight:
162.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352115
EC Number:
208-488-9
MDL number:
Beilstein/REAXYS Number:
6826
Product Name
CDI, ≥97.0% (T)
Quality Level
assay
≥97.0% (T)
form
solid
reaction suitability
reaction type: Carbonylations
greener alternative product characteristics
Designing Safer Chemicals
Learn more about the Principles of Green Chemistry.
sustainability
Greener Alternative Product
mp
115-122 °C, 117-122 °C (lit.)
application(s)
peptide synthesis
greener alternative category
storage temp.
2-8°C
SMILES string
O=C(n1ccnc1)n2ccnc2
InChI
1S/C7H6N4O/c12-7(10-3-1-8-5-10)11-4-2-9-6-11/h1-6H
InChI key
PFKFTWBEEFSNDU-UHFFFAOYSA-N
General description
CDI serves as a powerful coupling reagent in peptide synthesis and organic chemistry.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. 1,1′-carbonyldiimidazole (CDI) is an alternative to highly toxic insidious poison phosgene and thus aligns with the principle "Designing Safer Chemicals". Click here for more information.
Application
CDI (1,1′-Carbonyldiimidazole) can be used:
- In the activation of malonic acid derivatives to prepare carbonyl imidazoles by mild decarboxylation.
- In the activation of cellulose membranes for the development of immunosensors.
- In the synthesis of substituted 1,3-oxazolo[4,5-d] pyridazinones.
- As a reagent for the conversion of various hydroxamic acids to isocyanates by Lossen rearrangement.
- In the synthesis of 1,3,4-oxadiazole derivatives , and peptide thioesters in water.
- As an acylation agent for the synthesis of carbamates.
Other Notes
Reactive reagent for the activation of acids as imidazolides: synthesis of esters, amides, ketones etc. Reagent for immobilizing enzymes and affinity ligands; Carbonyl-transfer reagent for the synthesis of various heterocycles, some recent applications
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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S.K. Kang et al.
Synthetic Communications, 23, 2219-2219 (1993)
1,1'-Carbonyldiimidazole-mediated immobilization of enzymes and affinity ligands.
M T Hearn
Methods in enzymology, 135, 102-117 (1987-01-01)
Mechanochemical 1, 1′-Carbonyldiimidazole-Mediated Synthesis of Carbamates
Lanzillotto M, et al.
ACS sustainable chemistry & engineering, 11(3), 2882-2889 (2015)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 226610-10G | 04061837580741 |
| 226610-1G | 04061838780287 |
| 21860-100G | 04061838775528 |
| 21860-5G | 04061838775542 |
| 21860-25G | 04061838775535 |
| 21860-500G | 04065265030298 |