287199
Sulfadiazine
99%
Synonym(s):
4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide
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About This Item
Empirical Formula (Hill Notation):
C10H10N4O2S
CAS Number:
Molecular Weight:
250.28
EC Number:
200-685-8
UNSPSC Code:
12352103
MDL number:
Beilstein/REAXYS Number:
6733588
assay
99%
mp
253 °C (dec.) (lit.)
SMILES string
Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2
InChI
1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
InChI key
SEEPANYCNGTZFQ-UHFFFAOYSA-N
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Márcia Valéria Gaspar de Araújo et al.
Bioorganic & medicinal chemistry, 16(10), 5788-5794 (2008-04-25)
In this work we prepared and characterized an inclusion complex of the dihydropteroate synthase inhibitor sulfadiazine (SDZ) in 2-hydroxypropyl-beta-cyclodextrin (HPBCD). From the phase-solubility diagram we observed an increase in the water solubility of the drug, calculating a binding constant of
Pascale Meneceur et al.
Antimicrobial agents and chemotherapy, 52(4), 1269-1277 (2008-01-24)
Sulfadiazine, pyrimethamine, and atovaquone are widely used for the treatment of severe toxoplasmosis. Their in vitro activities have been almost exclusively demonstrated on laboratory strains belonging to genotype I. We determined the in vitro activities of these drugs against 17
Ahmed Kamal et al.
Bioorganic & medicinal chemistry, 15(2), 1004-1013 (2006-11-14)
A series of N'-1-[2-anilino-3-pyridyl]carbonyl-1-benzenesulfonohydrazide derivatives (7a-i) was synthesized and five of them were selected by the National Cancer Institute (NCI) and evaluated for their in vitro anticancer activity. Three of the investigated compounds 7d, 7f and 7g exhibited significant anticancer
Recent developments in fragment-based drug discovery.
Miles Congreve et al.
Journal of medicinal chemistry, 51(13), 3661-3680 (2008-05-07)
Young Ah Kim et al.
Journal of medicinal chemistry, 51(13), 3934-3945 (2008-06-20)
Several 7-deaza-6-benzylthioinosine analogues with varied substituents on aromatic ring were synthesized and evaluated against Toxoplasma gondii adenosine kinase (EC.2.7.1.20). Structure-activity relationships indicated that the nitrogen atom at the 7-position does not appear to be a critical structural requirement. Molecular modeling
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