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Merck
CN

30681

L-4-Hydroxyproline methyl ester hydrochloride

≥98.0% (GC)

Synonym(s):

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride, trans-4-Hydroxyproline methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H11NO3 · HCl
CAS Number:
40216-83-9
Molecular Weight:
181.62
NACRES:
NA.22
PubChem Substance ID:
57648453
eCl@ss:
32160406
UNSPSC Code:
12352209
MDL number:
MFCD00080855
Beilstein/REAXYS Number:
4716932

Key Documents

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Product Name

L-4-Hydroxyproline methyl ester hydrochloride, ≥98.0% (GC)

InChI

1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/m1./s1

SMILES string

Cl.COC(=O)[C@@H]1C[C@@H](O)CN1

InChI key

KLGSHNXEUZOKHH-JBUOLDKXSA-N

assay

≥98.0% (GC)

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

application(s)

peptide synthesis

Quality Level

100

Related Categories

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ3391
BCCG9194
BCCG2246
BCBQ5702V
BCBF7170V

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Emily M Christensen et al.
The Journal of biological chemistry, 295(52), 18316-18327 (2020-10-29)
Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of

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