Skip to Content
Merck
CN

Key Documents

View All Documentation

328820

4-Fluorophenylmagnesium bromide solution

1.0 M in THF

Synonym(s):

p-Fluorophenylmagnesium bromide, Bromo(4-fluorophenyl)magnesium, Bromo(p-fluorophenyl)magnesium

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
FC6H4MgBr
CAS Number:
352-13-6
Molecular Weight:
199.30
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
24859751
MDL number:
MFCD00009667
Beilstein/REAXYS Number:
636802
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

reaction suitability

reaction type: Grignard Reaction

packaging

Sure/Seal™ of

concentration

1.0 M in THF

density

1.021 g/mL at 25 °C

functional group

fluoro

SMILES string

Fc1ccc([Mg]Br)cc1

InChI

1S/C6H4F.BrH.Mg/c7-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1

InChI key

QYBFFRXNNFXREA-UHFFFAOYSA-M

Application

4-Fluorophenylmagnesium bromide solution (Grignard reagent) can be used as a reagent in the synthesis of:
  • Useful key intermediate in the synthesis of paroxetine.
  • Arylsulfides via cross-coupling reaction with thiols.
  • 4-Arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as androgen receptor antagonists.
  • Grignard intermediate for preparing aprepitant.

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

Still not finding the right product?

Explore all of our products under 4-Fluorophenylmagnesium bromide solution

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH014,EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-4.0 °F - closed cup

flash_point_c

-20 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
SHBT1904
SHBR3221
SHBQ7276
SHBP5859
SHBN0588

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Enantioselective synthesis of 3-substituted-4-aryl piperidines useful for the preparation of paroxetine
Murthy KS K, et al.
Tetrahedron Letters, 44(28), 5355-5358 (2003)
Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists
Yamamoto S, et al.
Bioorganic & Medicinal Chemistry, 20(7), 2338-2352 (2012)
Understanding the origin of unusual stepwise hydrogenation kinetics in the synthesis of the 3-(4-fluorophenyl) morpholine moiety of NK1 receptor antagonist aprepitant
Brands KMJ, et al.
Organic Process Research & Development, 10(1), 109-117 (2006)
View All Related Papers

Global Trade Item Number

SKUGTIN
328820-4X25ML04065268447406
328820-100ML04061826717875
328820-800ML04061826717882