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334618

trans-Diamminetetrachloroplatinum(IV)

Name: <I>trans</I>-Diamminetetrachloroplatinum(IV)
Brand: ALDRICH

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About This Item

Linear Formula:

Pt(NH₃)₂Cl₄

CAS Number:

16893-06-4

Molecular Weight:

370.95

UNSPSC Code:

12352302

MDL number:

MFCD00050045

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Properties

mp

>300 °C (lit.)

SMILES string

N.N.Cl[Pt](Cl)(Cl)Cl

InChI

1S/4ClH.2H3N.Pt/h4*1H;2*1H3;/q;;;;;;+4/p-4

InChI key

RBHOYUZKIANPPG-UHFFFAOYSA-J

Description

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Lot/Batch Number

05427TW

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Detection of DNA strand breaks in Escherichia coli treated with platinum(IV) antitumor compounds.

M Defais et al.

Chemico-biological interactions, 74(3), 343-352 (1990-01-01)

DNA strand breaks were observed in bacteria treated with Pt(IV) but not Pt(II) antitumor compounds by two methods. First, compounds which cause DNA strand breaks produced an SOS induction signal which was detected by a rapid bacterial assay. In addition

Induction and repair of DNA cross-links in chinese hamster ovary cells treated with various platinum coordination compounds in relation to platinum binding to DNA, cytotoxicity, mutagenicity, and antitumor activity.

A C Plooy et al.

Cancer research, 44(5), 2043-2051 (1984-05-01)

Several effects of four diamminechloroplatinum compounds (II and IV) in Chinese hamster ovary cells were studied. The two cis-compounds [cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV)] are known to possess antitumor activity, whereas the two trans-stereoisomers [trans-diamminedichloroplatinum(II) and trans-diamminetetrachloroplatinum(IV)] are inactive. When the effects

Toxicity, mutagenicity and induction of recA protein in Escherichia coli treated with cis-diamminedichloroplatinum(II) and cis-diamminetetrachloroplatinum(IV).

H Razaka et al.

Chemico-biological interactions, 60(2), 207-215 (1986-11-01)

After exposure of bacteria to equal concentrations of cis-diamminedichloroplatinum(II) (DDP) and cis-diamminetetrachloroplatinum(IV) (DTP), the intracellular concentration of DTP was an order of magnitude greater than DDP. However, at identical intracellular drug concentrations, the Pt(IV) compound formed only half as many