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Merck
CN

38827

Sigma-Aldrich

4,4′-Dimethoxytriphenylmethyl chloride

≥97.0% (HPLC)

Synonym(s):

4,4′-Dimethoxytrityl chloride, Chloro-4,4′-dimethoxytriphenylmethane, DMT, DMT-Cl

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About This Item

Empirical Formula (Hill Notation):
C21H19ClO2
CAS Number:
40615-36-9
Molecular Weight:
338.83
Beilstein:
2471942
EC Number:
255-002-6
MDL number:
MFCD00008409
UNSPSC Code:
12352101
PubChem Substance ID:
57649867
NACRES:
NA.22

Key Documents

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Quality Level

200

Assay

≥97.0% (HPLC)

mp

123-125 °C

functional group

chloro
phenyl

SMILES string

COc1ccc(cc1)C(Cl)(c2ccccc2)c3ccc(OC)cc3

InChI

1S/C21H19ClO2/c1-23-19-12-8-17(9-13-19)21(22,16-6-4-3-5-7-16)18-10-14-20(24-2)15-11-18/h3-15H,1-2H3

InChI key

JBWYRBLDOOOJEU-UHFFFAOYSA-N

Gene Information

human ... HTR2A(3356), HTR2B(3357), HTR2C(3358)
rat ... Htr1a(24473), Htr2a(29595)

Related Categories

Application

4,4′-Dimethoxytriphenylmethyl chloride (DMTrCl) can be used as a protecting agent:
  • For hydroxyl group of nucleosides/nucleotides as its O-(4,4′-dimethoxytrityl)derivative.
  • For 10 sulfhydryl group of oligonucleotide analogs as its DMTr thioether.

Other Notes

Useful protecting-group reagent; Removal

Signal Word

Danger

Hazard Statements

H314,H317,H335,H411

Hazard Classifications

Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8B - Non-combustible corrosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ1645
BCBW4855
BCBJ8463V
1442828V
1442828

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M.D. Matteucci et al.
Tetrahedron Letters, 81, 3243-3243 (1980)
2′-Deoxyimmunosine: stereoselective synthesis, base pairing and duplex stability of oligonucleotides containing 8-oxo-7-thiaguanine
Seela F and Ming X
Organic & Biomolecular Chemistry, 6(8), 1450-1461 (2008)
V. Amarnath et al.
Chemical Reviews, 77, 183-183 (1977)
Yuzhe Du et al.
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