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Merck
CN

441562

trans-1-Acetyl-4-hydroxy-L-proline

≥98%, for peptide synthesis

Synonym(s):

N-Acetyl-L-hydroxyproline

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About This Item

Empirical Formula (Hill Notation):
C7H11NO4
CAS Number:
33996-33-7
Molecular Weight:
173.17
NACRES:
NA.22
PubChem Substance ID:
24867668
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
251-780-6
MDL number:
MFCD00037339
Beilstein/REAXYS Number:
84043

Key Documents

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Product Name

trans-1-Acetyl-4-hydroxy-L-proline, ≥98%

Quality Level

100

InChI key

BAPRUDZDYCKSOQ-RITPCOANSA-N

InChI

1S/C7H11NO4/c1-4(9)8-3-5(10)2-6(8)7(11)12/h5-6,10H,2-3H2,1H3,(H,11,12)/t5-,6+/m1/s1

SMILES string

CC(=O)N1C[C@H](O)C[C@H]1C(O)=O

assay

≥98%

form

powder

optical activity

[α]20/D −119°, c = 4 in H2O

reaction suitability

reaction type: solution phase peptide synthesis

mp

132-133 °C (dec.) (lit.)

application(s)

peptide synthesis

Related Categories

Application

trans-1-Acetyl-4-hydroxy-L-proline can be used:
  • In the stereospecific synthesis of 4-fluoroglutamic acid.
  • To synthesize molecular targets for von Hippel-Lindau (VHL) E3 ubiquitin ligase.
  • As a precursor to synthesize pseudopoly(amino acids) such as poly(trans-4-hydroxy-4-acyl-L-proline ester) and a biodegradable polymer, poly(lactic acid-glycolic acid-4-hydroxyproline).

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H318

Hazard Classifications

Eye Dam. 1

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCZ4845
MKCX8097
MKCW4937
MKCM2266
MKCM2330

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Pseudopoly (amino acids): A Study of the Synthesis and Characterization of Poly (trans-4-hydroxy-N-acyl-L-proline esters).
Kwon H Y and Langer R
Macromolecules, 22(8), 3250-3255 (1989)
Stereospecific syntheses of all four stereoisomers of 4-fluoroglutamic acid.
Hudlicky M.
Journal of Fluorine Chemistry, 60(2-3), 193-210 (1993)
Structure-guided design and optimization of small molecules targeting the protein?protein interaction between the von Hippel?Lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities.
Galdeano C, et al.
Journal of Medicinal Chemistry, 57(20), 8657-8663 (2014)
Thi Mai Hoa Bach et al.
Applied microbiology and biotechnology, 97(1), 247-257 (2012-06-19)
The proline analogue cis-4-hydroxy-L-proline (CHOP), which inhibits the biosynthesis of collagen, has been clinically evaluated as an anticancer drug, but its water solubility and low molecular weight limits its therapeutic potential since it is rapidly excreted. In addition, CHOP is
H Riera et al.
Revue du rhumatisme et des maladies osteo-articulaires, 57(7-8), 579-583 (1990-07-01)
The authors have studied in organ culture, the effects of oxaceprol-structural analogue of hydroxyproline, on the proteoglycan and protein synthesis and degradation by calf articular chondrocytes. A stimulation of the incorporation of 35SO4, which indicate proteoglycan synthesis, was shown. The
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