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Merck
CN

459224

(S)-α-Amino-γ-butyrolactone hydrochloride

97%

Synonym(s):

L-Homoserine lactone hydrochloride, HSI

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About This Item

Empirical Formula (Hill Notation):
C4H7NO2 · HCl
CAS Number:
2185-03-7
Molecular Weight:
137.56
UNSPSC Code:
12352202
NACRES:
NA.22
PubChem Substance ID:
24869524
EC Number:
218-571-1
Beilstein/REAXYS Number:
3562187
MDL number:
MFCD00058172

Key Documents

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Product Name

(S)-α-Amino-γ-butyrolactone hydrochloride, 97%

InChI key

XBKCXPRYTLOQKS-DFWYDOINSA-N

InChI

1S/C4H7NO2.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H/t3-;/m0./s1

SMILES string

Cl.N[C@H]1CCOC1=O

assay

97%

form

powder or crystals

optical activity

[α]20/D −27.8°, c = 1 in H2O

mp

210-220 °C (dec.) (lit.)

application(s)

peptide synthesis

Quality Level

100

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Application

(S)-α-Amino-γ-butyrolactone hydrochloride can be used:
  • As a precursor for the preparation of amino-keto-alcohols and β-amino acids.
  • To prepare N-acylhomoserine lactone (AHL) analogs by reacting with substituted 2-chloro-N-phenylacetamide and different halides.
  • As a starting material for the synthesis of L-discadenine.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKBC9254V
MKBC9254
18911JR
11903EQ

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Design, synthesis and antibacterial evaluation of novel AHL analogues
Ren J, et al.
Bioorganic & Medicinal Chemistry Letters, 23(14), 4154-4156 (2013)
Natural products from social amoebae
Barnett R and Stallforth P
Chemistry?A European Journal , 24(17), 4202-4214 (2018)
Reaction of (S)-homoserine lactone with Grignard reagents: synthesis of amino-keto-alcohols and β-amino acid derivatives
Gundogdu O, et al.
Tetrahedron Asymmetry, 28(9), 1163-1168 (2017)
L R Brunham et al.
The pharmacogenomics journal, 14(6), 555-563 (2014-05-28)
Differences in the frequency of pharmacogenomic variants may influence inter-population variability in drug efficacy and risk of adverse drug reactions (ADRs). We investigated the diversity of ∼ 4500 genetic variants in key drug-biotransformation and -response genes among three South East
Fiorela Nievas et al.
Sensors (Basel, Switzerland), 12(3), 2851-2873 (2012-06-28)
Bacteria of the genus Bradyrhizobium are able to establish a symbiotic relationship with peanut (Arachis hypogaea) root cells and to fix atmospheric nitrogen by converting it to nitrogenous compounds. Quorum sensing (QS) is a cell-cell communication mechanism employed by a
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