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About This Item
Empirical Formula (Hill Notation):
C18H17NO4
CAS Number:
Molecular Weight:
311.33
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
MDL number:
Beilstein/REAXYS Number:
2302327
InChI
1S/C18H17NO4/c20-17(21)9-10-19-18(22)23-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,19,22)(H,20,21)
SMILES string
OC(=O)CCNC(=O)OCC1c2ccccc2-c3ccccc13
InChI key
LINBWYYLPWJQHE-UHFFFAOYSA-N
assay
≥99.0% (HPLC)
form
powder or crystals
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
mp
142-147 °C
application(s)
peptide synthesis
functional group
Fmoc
storage temp.
2-8°C
Quality Level
Application
Fmoc-β-Ala-OH is used as a linker to synthesize peptides on a monolithic GMA-EDMA (glycidyl methacrylate-co-ethylene dimethacrylate) matrix via Fmoc solid phase peptide synthesis.
General description
Fmoc-β-Ala-OH also known as Fmoc-β-alanine, is a versatile reagent for solid phase peptide synthesis.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Solid phase peptide synthesis on epoxy-bearing methacrylate monoliths
E Vlakh
Journal of Peptide Science, 10, 719-730 (2004)
Sofie Trier et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 96, 329-337 (2015-09-09)
Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation, as well as increasing enzymatic stability and interactions with lipid cell membranes. Thus, acylation offers several potential benefits for oral delivery of therapeutic peptides, and
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