Key Documents

View All Documentation

663190

Ethyl 5-methylindole-2-carboxylate

Name: Ethyl 5-methylindole-2-carboxylate
Brand: ALDRICH

97%

Synonym(s):

5-Methylindole-2-carboxylic acid ethyl ester, NSC 30928

Select a Size

Change View

About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₃NO₂

CAS Number:

16382-15-3

Molecular Weight:

203.24

NACRES:

NA.22

PubChem Substance ID:

24884618

UNSPSC Code:

12352100

MDL number:

MFCD00022703

Assay:

97%

Form:

solid

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Quality Level

100

assay

97%

form

solid

mp

160-164 °C

functional group

ester

SMILES string

CCOC(=O)c1cc2cc(C)ccc2[nH]1

InChI

1S/C12H13NO2/c1-3-15-12(14)11-7-9-6-8(2)4-5-10(9)13-11/h4-7,13H,3H2,1-2H3

InChI key

KMVFKXFOPNKHEM-UHFFFAOYSA-N

Description

General description

Ethyl 5-methylindole-2-carboxylate (5-Methylindole-2-carboxylic acid ethyl ester) is an indole derivative. Indole ring system is an important building block or intermediate in the synthesis of many pharmaceutical agents. It is formed during the Fischer indolization of ethyl pyruvate 2-[2-(methanesulfonyloxy)-4-methyl]phenylhydrazine.

Application

Reactant for synthesis of oxazino[4,3-a]indoles via cascade addition-cyclization reactions
Reactant for preparation of indolecarboxamides as cannabinoid CB1 receptor antagonists
Reactant for preparation of indole-3-propionic acids as antiinflammatory and analgesic agents
Reactant for Friedel-Crafts acylation with nitrobenzoyl chloride
Reactant for oximation reactions

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

新产品

This item has

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Articles

Friedel–Crafts Acylation

Friedel-Crafts acylation with Lewis acid catalysts forms monoacylated products via electrophilic aromatic substitution of arenes.

傅-克酰基化反应

傅-克酰基化反应是一种芳烃与酰氯或酸酐使用强路易斯酸催化剂的反应。该反应通过亲电芳族取代进行，形成单酰化产物。

Substituent Effects in the Fischer Indolization of (2-Sulfonyloxyphenyl) hydrazones (Fischer Indolization and Related Compounds. XXX).

Murakami Y, et al.

Chemical & Pharmaceutical Bulletin, 47, 791-797 (1999)

Global Trade Item Number

SKU	GTIN
663190-5G	04061832842028
663190-1G	04061826138137