679585
4-Methoxybenzyl-2,2,2-trichloroacetimidate
Synonym(s):
p-Methoxybenzyl trichloroacetimidate
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About This Item
Empirical Formula (Hill Notation):
C10H10Cl3NO2
CAS Number:
Molecular Weight:
282.55
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352101
MDL number:
impurities
Major impurity is Trichloroacetamide by GCMS.
Quality Segment
refractive index
n
bp
135-137 °C/0.7 mmHg
density
1.361 g/mL at 25 °C
functional group
chloro, ether
storage temp.
2-8°C
SMILES string
COc1ccc(COC(=N)C(Cl)(Cl)Cl)cc1
InChI
1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3
InChI key
TYHGKLBJBHACOI-UHFFFAOYSA-N
Application
4-Methoxybenzyl-2,2,2-trichloroacetimidate can be used as a reagent for the protection of alcohols as the p-methoxybenzyl ether. 1o, 2o, and 3o alcohols can be easily protected using this reagent with equal efficiency in the presence of a variety of different protective groups. This reagent is commonly used under acidic conditions therefore it offers an alternative method to the Williamson ether synthesis, which is typically used basic conditions to protect base-sensitive alcohols.
signalword
Warning
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
>230.0 °F
flash_point_c
> 110 °C
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