4-Methoxybenzyl-2,2,2-trichloroacetimidate

Name: 4-Methoxybenzyl-2,2,2-trichloroacetimidate
Brand: ALDRICH

Synonym(s):

p-Methoxybenzyl trichloroacetimidate

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₀Cl₃NO₂

CAS Number:

89238-99-3

Molecular Weight:

282.55

NACRES:

NA.22

PubChem Substance ID:

24885502

UNSPSC Code:

12352101

MDL number:

MFCD00134547

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Properties

impurities

Major impurity is Trichloroacetamide by GCMS.

Quality Level

100

refractive index

n20/D 1.5488

bp

135-137 °C/0.7 mmHg

density

1.361 g/mL at 25 °C

functional group

chloro, ether

storage temp.

2-8°C

SMILES string

COc1ccc(COC(=N)C(Cl)(Cl)Cl)cc1

InChI

1S/C10H10Cl3NO2/c1-15-8-4-2-7(3-5-8)6-16-9(14)10(11,12)13/h2-5,14H,6H2,1H3

InChI key

TYHGKLBJBHACOI-UHFFFAOYSA-N

Description

Application

4-Methoxybenzyl-2,2,2-trichloroacetimidate can be used as a reagent for the protection of alcohols as the p-methoxybenzyl ether. 1^o, 2^o, and 3^o alcohols can be easily protected using this reagent with equal efficiency in the presence of a variety of different protective groups. This reagent is commonly used under acidic conditions therefore it offers an alternative method to the Williamson ether synthesis, which is typically used basic conditions to protect base-sensitive alcohols.