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687901

4-(Trifluoromethoxy)phenylmagnesium bromide solution

0.5 M in THF

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About This Item

Empirical Formula (Hill Notation):
C7H4BrF3MgO
Molecular Weight:
265.31
NACRES:
NA.22
PubChem Substance ID:
329760826
UNSPSC Code:
12352103
MDL number:
MFCD09842767
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form

liquid

Quality Level

100

reaction suitability

reaction type: Grignard Reaction

packaging

Sure/Seal™ of

concentration

0.5 M in THF

density

0.975 g/mL at 25 °C

functional group

fluoro

SMILES string

FC(F)(F)Oc1ccc([Mg]Br)cc1

InChI

1S/C7H4F3O.BrH.Mg/c8-7(9,10)11-6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1

InChI key

UFMHNMPAQCQXMW-UHFFFAOYSA-M

Application

Reactant for:
  • Preparation of chromanol derivatives as novel class of CETP inhibitors for treatment of cardiovascular disease
  • Pd-catalyzed cross coupling
  • Preparation of indazole-pyridine derivatives as protein kinase B/Akt inhibitors with reduced hypotension, via Stille coupling, Mitsunobu reaction and copper-catalyzed aziridine ring-opening reaction

Legal Information

Sure/Seal is a trademark of Sigma-Aldrich Co. LLC

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH014,EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

-22.0 - -4.0 °F - closed cup

flash_point_c

-30 - -20 °C - closed cup

Regulatory Information

危险化学品

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Certificates of Analysis (COA)

Lot/Batch Number
0000352486
0000300117
0000300117
0000352486
SHBG6030V

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Global Trade Item Number

SKUGTIN
687901-50ML04061838128928