759317
4,4,4,4′,4′,4′-Hexafluoro-DL-valine
97%
Synonym(s):
2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric acid, 4,4,4,5,5,5-Hexafluoro-DL-valine
Sign Into View Organizational & Contract Pricing
Select a Size
About This Item
Linear Formula:
(CF3)2CHCH(NH2)COOH
CAS Number:
Molecular Weight:
225.09
Beilstein:
2416649
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
Quality Level
Assay
97%
form
crystals
mp
196-217 °C
application(s)
peptide synthesis
functional group
amine
carboxylic acid
fluoro
SMILES string
NC(C(C(F)(F)F)C(F)(F)F)C(O)=O
InChI
1S/C5H5F6NO2/c6-4(7,8)2(5(9,10)11)1(12)3(13)14/h1-2H,12H2,(H,13,14)
InChI key
KRNSHCKTGFAMPQ-UHFFFAOYSA-N
Looking for similar products? Visit Product Comparison Guide
Related Categories
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
W H Vine et al.
Journal of medicinal chemistry, 24(9), 1043-1047 (1981-09-01)
Gamma, gammma, gammma, gammma', gamma', gammma'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis. Hexafluorovaline derivatives showed general resistance toward various enzymatic digestions and the tendency to racemize extensively upon carboxyl
K H Hsieh et al.
Journal of medicinal chemistry, 30(6), 1097-1100 (1987-06-01)
An improved synthesis of hexafluorovaline (Hfv) derivatives, i.e., DL-Hfv-OBzl and Boc-DL-Hfv, is described. Incorporation of hexafluorovaline into angiotensin resulted in [Sar1,Hfv8]AII and [Sar1,D-Hfv8]AII. At the nanogram/milliliter dose range, the L congener was 20-100 times more active as either angiotensin agonist
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service