Skip to Content
Merck
CN

Key Documents

View All Documentation

759317

4,4,4,4′,4′,4′-Hexafluoro-DL-valine

97%

Synonym(s):

2-Amino-4,4,4-trifluoro-3-(trifluoromethyl)butyric acid, 4,4,4,5,5,5-Hexafluoro-DL-valine

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
(CF3)2CHCH(NH2)COOH
CAS Number:
16063-80-2
Molecular Weight:
225.09
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
329766772
EC Number:
240-207-5
Beilstein/REAXYS Number:
2416649
MDL number:
MFCD00014349
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Level

100

assay

97%

form

crystals

mp

196-217 °C

application(s)

peptide synthesis

functional group

amine, carboxylic acid, fluoro

SMILES string

NC(C(C(F)(F)F)C(F)(F)F)C(O)=O

InChI

1S/C5H5F6NO2/c6-4(7,8)2(5(9,10)11)1(12)3(13)14/h1-2H,12H2,(H,13,14)

InChI key

KRNSHCKTGFAMPQ-UHFFFAOYSA-N

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKBM1254

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

W H Vine et al.
Journal of medicinal chemistry, 24(9), 1043-1047 (1981-09-01)
Gamma, gammma, gammma, gammma', gamma', gammma'-Hexafluorovaline and derivatives have been prepared and incorporated into angiotensin II by fragment condensation and solid-phase peptide synthesis. Hexafluorovaline derivatives showed general resistance toward various enzymatic digestions and the tendency to racemize extensively upon carboxyl
K H Hsieh et al.
Journal of medicinal chemistry, 30(6), 1097-1100 (1987-06-01)
An improved synthesis of hexafluorovaline (Hfv) derivatives, i.e., DL-Hfv-OBzl and Boc-DL-Hfv, is described. Incorporation of hexafluorovaline into angiotensin resulted in [Sar1,Hfv8]AII and [Sar1,D-Hfv8]AII. At the nanogram/milliliter dose range, the L congener was 20-100 times more active as either angiotensin agonist

Global Trade Item Number

SKUGTIN
759317-250MG04061831832174