760668
Dibenzocyclooctyne-maleimide
for Copper-free Click Chemistry
Synonym(s):
DBCO-maleimide
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About This Item
Empirical Formula (Hill Notation):
C25H21N3O4
Molecular Weight:
427.45
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352111
MDL number:
Form:
solid
Quality Segment
form
solid
reaction suitability
reaction type: click chemistry, reagent type: cross-linking reagent
functional group
maleimide
storage temp.
−20°C
SMILES string
O=C(N1CCC(NCCC(N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4)=O)=O)C=CC1=O
InChI
1S/C25H21N3O4/c29-22(14-16-27-23(30)11-12-24(27)31)26-15-13-25(32)28-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)28/h1-8,11-12H,13-17H2,(H,26,29)
InChI key
NHFQNAGPXIVKND-UHFFFAOYSA-N
Application
Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Applications Include:
Applications Include:
- Protein-peptide conjugates
- Antibody-enzyme or antibody-drug conjugates
- Protein or peptide-oligonucleotide conjugates
- Surface modification
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