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Merck
CN

901594

Diisopropylcarbodiimide solution

1 M in THF

Synonym(s):

Diisopropylmethanediimine

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About This Item

Linear Formula:
C7H14N2
CAS Number:
693-13-0
UNSPSC Code:
12352111
NACRES:
NA.22
MDL number:
MFCD00065689

Key Documents

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Product Name

Diisopropylcarbodiimide solution, 1 M in THF

SMILES string

N(=C=NC(C)C)C(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

form

liquid

reaction suitability

reaction type: Coupling Reactions

concentration

1 M in THF

density

0.870 g/mL

application(s)

peptide synthesis

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Related Categories

Application

Coupling reagent for peptide syntheses.
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Valuable reagent offered as a solution in tetrahydrofuran for more convenient handling.

signalword

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

supp_hazards

EUH019

Storage Class

3 - Flammable liquids

wgk

WGK 3

flash_point_f

2.0 °F

flash_point_c

-16.66 °C

Regulatory Information

危险化学品
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Certificates of Analysis (COA)

Lot/Batch Number
MKCX5315
MKCG2872
MKCW1383
MKCR3315

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Stéphane Chantepie et al.
PloS one, 10(7), e0133140-e0133140 (2015-07-29)
Do all traits within an organism age for the same reason? Evolutionary theories of aging share a common assumption: the strength of natural selection declines with age. A corollary is that additive genetic variance should increase with age. However, not
Cody L Gilleland et al.
Genetics, 201(1), 39-46 (2015-07-15)
A major goal in the study of human diseases is to assign functions to genes or genetic variants. The model organism Caenorhabditis elegans provides a powerful tool because homologs of many human genes are identifiable, and large collections of genetic
Qiu Dai et al.
Journal of the American Chemical Society, 127(22), 8008-8009 (2005-06-02)
Gold nanoparticles with a single carboxylic acid group on the surface were prepared from a solid phase place exchange reaction and then coupled to polylysine using an in situ activation agent, diisopropylcarbodiimide (DIPCDI). The covalent amide bond linkage between the
Adam B Weinglass et al.
The Journal of biological chemistry, 280(9), 7487-7492 (2004-12-30)
EmrE is a small multidrug transporter in Escherichia coli that extrudes various positively charged drugs across the plasma membrane in exchange with protons, thereby rendering cells resistant to these compounds. Biochemical experiments indicate that the basic functional unit of EmrE
Tianyi Zhang et al.
Journal of cell science, 128(15), 2938-2950 (2015-06-21)
The v-ATPase is a fundamental eukaryotic enzyme that is central to cellular homeostasis. Although its impact on key metabolic regulators such as TORC1 is well documented, our knowledge of mechanisms that regulate v-ATPase activity is limited. Here, we report that
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