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Merck
CN

914924

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid

≥95%

Synonym(s):

3-((2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)disulfaneyl)propanoic acid, Biotin-SS-COOH, Cleavable biotin linker

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About This Item

Empirical Formula (Hill Notation):
C15H25N3O4S3
CAS Number:
104582-29-8
Molecular Weight:
407.57
UNSPSC Code:
12352106
NACRES:
NA.22
MDL number:
MFCD04039425

Key Documents

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Product Name

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid, ≥95%

SMILES string

S1[C@H]([C@H]2NC(=O)N[C@H]2C1)CCCCC(=O)NCCSSCCC(=O)O

InChI

1S/C15H25N3O4S3/c19-12(16-6-8-25-24-7-5-13(20)21)4-2-1-3-11-14-10(9-23-11)17-15(22)18-14/h10-11,14H,1-9H2,(H,16,19)(H,20,21)(H2,17,18,22)/t10-,11-,14-/m0/s1

InChI key

LUKYYZVIDAWYMZ-MJVIPROJSA-N

assay

≥95%

form

powder

mp

172-175 °C

storage temp.

−20°C

Quality Level

100

Application

3-[2-N-(Biotinyl)aminoethyldithio]propanoic acid (Biotin-SS-COOH) is a cleavable, biotinylated crosslinkers. The linker can also be used for synthesis of chemical biology tools for labeling target proteins in biological experiments and assays. It possesses dual functionality: enrichment via the biotin and an embedded disulfide bridge for cleavage under reducing conditions.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

Other Notes

Uniformly Cationized Protein Efficiently Reaches the Cytosol of Mammalian Cells

A Mechanism-Based ICAT Strategy for Comparing Relative Expression and Activity Levels of Glycosidases in Biological Systems

Dissociation-independent selection of high-affinity anti-hapten phage antibodies using cleavable biotin-conjugated haptens

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
MKCM5501
MKCT2569

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