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H8378

D-α-Hydroxyglutaric acid disodium salt

Name: <SC>D</SC>-&#945;-Hydroxyglutaric acid disodium salt
Brand: ALDRICH

≥95% (GC), cell analysisfor peptide synthesis

Synonym(s):

(R)-2-Hydroxypentanedioic acid disodium salt, Disodium (R)-2-hydroxyglutarate

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About This Item

Linear Formula:

C₅H₆O₅Na₂

CAS Number:

103404-90-6

Molecular Weight:

192.08

NACRES:

NA.22

PubChem Substance ID:

57654274

UNSPSC Code:

12352106

MDL number:

MFCD00069573

Beilstein/REAXYS Number:

5318041

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Product Name

D-α-Hydroxyglutaric acid disodium salt, ≥95% (GC)

Quality Level

200

assay

≥95% (GC)

form

powder

color

white to off-white

application(s)

cell analysis
peptide synthesis

storage temp.

−20°C

SMILES string

[Na].O[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H8O5.2Na/c6-3(5(9)10)1-2-4(7)8;;/h3,6H,1-2H2,(H,7,8)(H,9,10);;/q;2*+1/p-2/t3-;;/m1../s1

InChI key

DZHFTEDSQFPDPP-HWYNEVGZSA-L

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Related Categories

Amino Acids, Resins & Reagents for Peptide Synthesis

Biochemicals

Cell Culture Supplements & Reagents

Building Blocks, Resins, and Coupling Reagents for GLP-1 Synthesis

Amino Acids – Building Blocks of Life Science

Application

D-α-Hydroxyglutaric acid disodium salt can be used as a reagent in peptide synthesis.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis.

Shan Jin et al.

Nature communications, 14(1), 6638-6638 (2023-10-21)

Mammalian lactate dehydrogenase D (LDHD) catalyzes the oxidation of D-lactate to pyruvate. LDHD mutations identified in patients with D-lactic acidosis lead to deficient LDHD activity. Here, we perform a systematic biochemical study of mouse LDHD (mLDHD) and determine the crystal

The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells.

Liu Y, Gilbert MR, Kyprianou N, et al.

Acta Neuropathologica, 128(5), 723-732 (2014)

2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.

M Hans et al.

European journal of biochemistry, 265(1), 404-414 (1999-09-22)

Component D (HgdAB) of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum was purified to homogeneity. It is able to use component A from Acidaminococcus fermentans (HgdC) to initiate catalysis together with ATP, Mg2+ and a strong reducing agent such as Ti(III)citrate. Component

Postoperative risk of IDH mutant glioma-associated seizures and their potential management with IDH mutant inhibitors.

Drumm, et al.

The Journal of Clinical Investigation (2023)

Mutant IDH Sensitizes Gliomas to Endoplasmic Reticulum Stress and Triggers Apoptosis via miR-183-Mediated Inhibition of Semaphorin 3E.

Ying Zhang et al.

Cancer research, 79(19), 4994-5007 (2019-08-09)

Human astrocytomas and oligodendrogliomas are defined by mutations of the metabolic enzymes isocitrate dehydrogenase (IDH) 1 or 2, resulting in the production of the abnormal metabolite D-2 hydroxyglutarate. Here, we studied the effect of mutant IDH on cell proliferation and

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Protocols

Chiral LC-MS/MS of D- and L-2-Hydroxyglutaric Acid Biomarkers

We describe here a rapid and sensitive method to separate and measure D-2-OHG and L-2-OHG enantiomers using high-resolution mass spectrometry (HRMS) detection.

Global Trade Item Number

SKU	GTIN
H8378-250MG	04061833810651
H8378-100MG	04061833809198

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