C195
(2S,3R,4S)-α-(Carboxycyclopropyl)glycine
solid
Synonym(s):
(2S,1′R,2′S)-2-(2-Carboxycyclopropyl)glycine, (2S,3R,4S)-CCG, L-CCG-IV
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About This Item
Empirical Formula (Hill Notation):
C6H9NO4
CAS Number:
Molecular Weight:
159.14
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
12352209
MDL number:
form
solid
optical activity
[α]/D +69.5°, c = 0.4 in H2O(lit.)
reaction suitability
reaction type: solution phase peptide synthesis
color
off-white
solubility
H2O: soluble
application(s)
peptide synthesis
SMILES string
[H][C@]1(C[C@@H]1C(O)=O)[C@H](N)C(O)=O
InChI
1S/C6H9NO4/c7-4(6(10)11)2-1-3(2)5(8)9/h2-4H,1,7H2,(H,8,9)(H,10,11)/t2-,3+,4+/m1/s1
InChI key
GZOVEPYOCJWRFC-UZBSEBFBSA-N
Biochem/physiol Actions
Potent NMDA receptor agonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Jennifer A Feeley Kearney et al.
Experimental neurology, 184 Suppl 1, S30-S36 (2003-11-05)
Metabotropic glutamate receptors (mGluRs) are G-protein-coupled excitatory amino acid (glutamate) receptors and are abundantly expressed in basal ganglia nuclei. We used behavioral, regional glucose uptake metabolic mapping, and FOS protein expression to examine the effects of stimulating striatal and subthalamic
Timo Kirschstein et al.
Neuropharmacology, 47(2), 157-162 (2004-06-30)
Specific agonists of metabotropic glutamate receptors (mGluRs) provide powerful tools to discriminate afferent fibers originating from different presynaptic neurons. The group II mGluR agonists L-CCG-I ((2S,1'S,2'S)-2-(2-carboxycyclopropyl)glycine) and DCG-IV ((2S,2'R,3'R)-2-(2',3'-dicarboxy-cyclopropyl)glycine) are commonly used to distinguish between mossy fiber and associational-commissural (A/C)
Ke-Zhong Shen et al.
The Journal of physiology, 553(Pt 2), 489-496 (2003-09-23)
Patch pipettes were used to record currents in whole-cell configuration to study the effects of group II metabotropic glutamate receptor (mGluR) stimulation on synaptic transmission in slices of rat subthalamic nucleus. Evoked glutamatergic excitatory postsynaptic currents (EPSCs) were reversibly reduced
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB1300517-100UG | 04061831470222 |
| C195-1MG | 04061826107539 |