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Merck
CN

N22908

3-Nitropropionic acid

97%

Synonym(s):

β-Nitropropionic acid, 3-Nitropropanoic acid, Bovinocidin, Hiptagenic acid

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About This Item

Linear Formula:
O2N(CH2)2CO2H
CAS Number:
Molecular Weight:
119.08
UNSPSC Code:
12352103
NACRES:
NA.22
PubChem Substance ID:
EC Number:
208-003-0
Beilstein/REAXYS Number:
1759889
MDL number:
Assay:
97%
Form:
crystals
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InChI key

WBLZUCOIBUDNBV-UHFFFAOYSA-N

InChI

1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)

SMILES string

OC(CC[N+]([O-])=O)=O

assay

97%

form

crystals

mp

68-70 °C (lit.)

storage temp.

2-8°C

Quality Level

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Biochem/physiol Actions

Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.

pictograms

Skull and crossbones

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Danger

hcodes

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges


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Emmanuel Brouillet et al.
Journal of neurochemistry, 95(6), 1521-1540 (2005-11-23)
Huntington's disease (HD) is a neurodegenerative disorder caused by a mutation in the gene encoding Huntingtin. The mechanisms underlying the preferential degeneration of the striatum, the most striking neuropathological change in HD, are unknown. Of those probably involved, mitochondrial defects
C V Borlongan et al.
Neuroscience and biobehavioral reviews, 21(3), 289-293 (1997-05-01)
Huntington's disease (HD) is a progressive neurodegenerative disorder associated with severe degeneration of basal ganglia neurons, especially the intrinsic neurons of the striatum, and characterized by progressive dementia and involuntary abnormal choreiform movements. Despite our increasing knowledge of the pathophysiology
Tohru Yamamori et al.
Free radical biology & medicine, 53(2), 260-270 (2012-05-15)
Whereas ionizing radiation (Ir) instantaneously causes the formation of water radiolysis products that contain some reactive oxygen species (ROS), ROS are also suggested to be released from biological sources in irradiated cells. It is now becoming clear that these ROS
E Brouillet et al.
Current opinion in neurology, 8(6), 469-473 (1995-12-01)
Compelling evidence suggests that a defect in energy metabolism may play a role in the pathogenesis of various degenerative disorders including Parkinson's disease and Huntington's disease. The behavioural and neuropathological consequences in primates of chronic systemic administration of mitochondrial toxins
Rajat Sandhir et al.
Biochimica et biophysica acta, 1832(3), 421-430 (2012-12-12)
The study was designed to investigate the beneficial effect of quercetin supplementation in 3-nitropropionic acid (3-NP) induced model of Huntington's disease (HD). HD was induced in rats by administering sub-chronic dose of 3-NP, intraperitoneally, twice daily for 17days. Quercetin was

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