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About This Item
Linear Formula:
(C6H5)3CCl
CAS Number:
Molecular Weight:
278.78
UNSPSC Code:
12352101
NACRES:
NA.22
PubChem Substance ID:
EC Number:
200-986-4
Beilstein/REAXYS Number:
397363
MDL number:
Product Name
Trityl chloride, 97%
InChI
1S/C19H15Cl/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
InChI key
JBWKIWSBJXDJDT-UHFFFAOYSA-N
SMILES string
ClC(c1ccccc1)(c2ccccc2)c3ccccc3
assay
97%
bp
230-235 °C/20 mmHg (lit.)
mp
109-112 °C (lit.)
Quality Level
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Application
Protecting reagent for amines, alcohols, and thiols.
Trityl chloride can be used as a catalyst:
- In Ritter type synthesis of 1-amidoalkyl-2-naphtols through a one-pot three-component reaction of naphthol, aryl aldehydes and acetonitrile.
- In the synthesis of 1,2,4,5-tetrasubstituted imidazoles via a one-pot multi-component reaction of benzil with aldehydes, primary amines, and ammonium acetate.
- In the preparation of amido alkyl phenols via one-pot, multi-component reaction of phenols, aromatic aldehydes, and amides under solvent-free conditions.
- In one-pot, multi-component synthesis of substituted piperidines using aromatic aldehydes, amines, and β-ketoesters.
signalword
Danger
hcodes
Hazard Classifications
Skin Corr. 1B
Storage Class
8A - Combustible corrosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Tetrahedron Letters, 48, 5017-5017 (2007)
One pot synthesis of 1, 2, 4, 5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media
Moosavi-Zare AR, et al.
Royal Society of Chemistry Advances, 4(105), 60636-60639 (2014)
Trityl chloride as an efficient organic catalyst for one-pot, five-component and diastereoselective synthesis of highly substituted piperidines
Sajadikhah SS, et al.
Research on Chemical Intermediates, 40(2), 723-736 (2014)
Trityl chloride as an efficient organic catalyst for the synthesis of 1-amidoalkyl-2-naphtols in neutral media at room temperature
Khazaei A, et al.
Applied Catalysis A: General, 386(1-2), 179-187 (2010)
Solvent-free preparation of amidoalkyl phenols catalyzed by trityl chloride under neutral media
Moosavi-Zare AZ, et al.
Canadian Journal of Chemistry, 93(11), 1245-1248 (2015)
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