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Merck
CN

16-233

Anti-FAK Antibody, clone 4.47, Alexa Fluor™ 488 conjugate

clone 4.47, Upstate®, from mouse

Synonym(s):

Anti-FADK, Anti-FADK 1, Anti-FAK, Anti-FAK1, Anti-FRNK, Anti-PPP1R71, Anti-p125FAK, Anti-pp125FAK

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
ALEXA FLUOR™ 488
Clone:
4.47, monoclonal
Application:
FACS, ICC, WB
Citations:
15

Key Documents

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biological source

mouse

conjugate

ALEXA FLUOR™ 488

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4.47, monoclonal

species reactivity

human, rat, mouse

manufacturer/tradename

Upstate®

technique(s)

flow cytometry: suitable, immunocytochemistry: suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NM_005607.3, NM_153831.2

UniProt accession no.

Q05397

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... PTK2(5747)

Related Categories

General description

125kDa

Immunogen

GST fusion protein corresponding to residues 1-423 of human FAK (focal adhesion kinase)

Application

Detect FAK using this Anti-FAK Antibody, clone 4.47, Alexa Fluor 488 conjugate validated for use in FC, WB & IC.
Research Category
Signaling
Research Sub Category
Cytoskeletal Signaling

Biochem/physiol Actions

p125FAK, does not cross react with Pyk-2

Physical form

Protein G Purified

Preparation Note

1 year at 4°C from date of shipment

Analysis Note

Routinely evaluated by immunostaining of 3T3 cells.

Legal Information

ALEXA FLUOR is a trademark of Life Technologies
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Alexa Fluor™ is a registered trademark of Molecular Probes, Inc.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Focal adhesion kinase: in command and control of cell motility.
Mitra, Satyajit K, et al.
Nature Reviews in Molecular and Cell Biology, 6, 56-68 (2005)
Steven K Hanks et al.
Frontiers in bioscience : a journal and virtual library, 8, d982-d996 (2003-04-18)
Focal adhesion kinase (FAK) was first described in 1992 as a novel nonreceptor protein-tyrosine kinase localized prominently within focal adhesions, suggesting a signaling role in regulating cell behavior resulting from integrin interaction with the extracellular matrix. Subsequent studies over the
Nam Cong-Nhat Huynh et al.
PloS one, 11(7), e0159843-e0159843 (2016-07-22)
Rinsing the mouth with sodium chloride (NaCl) solution is believed to promote healthy gum and improve oral ulcer healing. Scientific evidence to support this assumption is, however, lacking. This study aims to investigate the effect and clarify underlying mechanisms of
David D Schlaepfer et al.
Current opinion in genetics & development, 14(1), 92-101 (2004-04-28)
The ability of intracellular signaling networks to orchestrate a complex biological response such as cell motility requires that individual signaling proteins must act as integrators, responding to multiple extracellular inputs and regulating multiple signaling pathway outputs. In this review, we
Julia Meller et al.
JCI insight, 2(11) (2017-06-02)
Microglia play a critical role in the development and homeostasis of the CNS. While mobilization of microglia is critical for a number of pathologies, understanding of the mechanisms of their migration in vivo is limited and often based on similarities
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