Tumor necrosis factor receptor superfamily member 3 (UniProt: P50284; also known as Lymphotoxin-beta receptor, LTBR) is encoded by the Ltbr (also known as Tnfcr, Tnfrsf3) gene (Gene ID: 17000) in murine species. The tumor necrosis factor (TNF) receptor superfamily comprises more than 20 type-I transmembrane proteins. LTBR is a single-pass type I membrane protein that contains 4 TNFR-Cys repeats and serves as a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. LTBR plays critical roles in inflammation and lymphoid organogenesis through activation of NF-kB pathway. The binding of heterotrimeric lymphotoxin to LTBR is shown to induce NF-kB activation and cell death in HT29 adenocarcinoma cells. LTBR activation promotes apoptosis via TRAF3 and TRAF5. It is also reported to play a role in the development of lymphoid organs. Mice deficient in the LTBR gene fail to form lymph nodes and lack NK and NK-T cells. In the adults, LTBR signaling is essential for maintaining the splenic architecture, for the integrity of marginal zones, and for compartmentalization of T and B cells.

Clone 3C8 detects Tumor necrosis factor receptor superfamily member 3 in NIH3T3 cells.

LT betaR-Fc decoy protein.

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Zhu, M., et. al. (2006). J Clin Invest. 116(11):2964-71).

Flow Cytometry Analysis: A representative lot detected LTBR in Flow Cytometry applications (Yi, T., et. al. (2013). Elife. 2:e00757).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Dejardin, E., et. al. (2002). Immunity. 17(4):525-35).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Vondenhoff, M.F., et. al. (2009). J Immunol. 182(9):5439-45).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Yi, T., et. al. (2013). Elife. 2:e00757).

Agonist or Inhibitor Analysis: A representative lot detected LTBR in Agonist or Inhibitor applications (Banks, T.A., et. al. (2005). J Immunol. 174(11):7217-25).

Research Category
Inflammation & Immunology

This rat monoclonal Anti-LTBR, clone 3C8, Cat. No. MABF2049, is tested for use in Flow Cytometry and in functional studies for the detection of Lymphotoxin-beta receptor/LTbeta R.

Evaluated by Flow Cytometry in NIH/3T3 cells.

Flow Cytometry Analysis: 1 µg of this antibody detected LTBR in one million NIH/3T3 cells.

44.95 kDa calculated.

Format: Purified

Protein G purified

Purified rat monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Concentration: Please refer to lot specific datasheet.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.