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Merck
CN

04712

Phenobarbital sodium salt

≥95.0% (NT)

Synonym(s):

5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt, 5-Ethyl-5-phenylbarbituric acid sodium salt, Luminal sodium salt, Sodium 5-ethyl-5-phenylbarbiturate

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About This Item

Empirical Formula (Hill Notation):
C12H11N2NaO3
CAS Number:
57-30-7
Molecular Weight:
254.22
EC Number:
200-322-3
UNSPSC Code:
12352200
MDL number:
MFCD00036211
Beilstein/REAXYS Number:
3802044

Key Documents

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assay

≥95.0% (NT)

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

loss

2-5% loss on drying

SMILES string

[Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2

InChI

1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1

InChI key

WRLGYAWRGXKSKG-UHFFFAOYSA-M

Biochem/physiol Actions

Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.

Other Notes

Sales restrictions may apply

pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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Jiahua Guo et al.
Ecotoxicology and environmental safety, 160, 94-103 (2018-05-25)
This work aimed at evaluating the toxic effects of in ovo exposure to phenobarbital (PB) and unveiling the mode of action by transcriptome analysis in the embryonic liver of a model avian species, chicken (Gallus gallus). Embryos were initially treated
Richard C Peffer et al.
Toxicological sciences : an official journal of the Society of Toxicology, 162(2), 582-598 (2017-12-16)
Experimental data demonstrate a mode of action (MOA) for liver tumors in male rats and mice treated with sedaxane that starts with activation of CAR, followed by altered expression of CAR-responsive genes, increased cell proliferation, and eventually clonal expansion of
Sayaka Mizukami et al.
Toxicology and applied pharmacology, 334, 207-216 (2017-09-14)
We previously found downregulation of ubiquitin-conjugating enzyme E2E 2 (UBE2E2) in GST-P-positive
Sayaka Mizukami et al.
Toxicological sciences : an official journal of the Society of Toxicology, 159(1), 211-223 (2017-09-15)
We previously observed downregulation of mitochondrial oxidative phosphorylation-related protein, TMEM70, which is suggestive of disrupted cellular senescence, in GST-P-expressing (+) proliferative lesions from early hepatocarcinogenesis stages in rats. The present study investigated the immunohistochemical relationship between TMEM70 downregulation and cellular
Joshua A Harrill et al.
Toxicology and applied pharmacology, 354, 24-39 (2018-04-08)
Medium- to high-throughput in vitro assays that recapitulate the critical processes of nervous system development have been proposed as a means to facilitate rapid testing and identification of chemicals which may affect brain development. In vivo neurodevelopment is a complex

Global Trade Item Number

SKUGTIN
32406-100MG04061826709535
107271-25ML04061838674722
107271-500ML04061838674760

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