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Merck
CN

09415

Sodium 4-aminosalicylate dihydrate

≥97.0% (T)

Synonym(s):

4-Amino-2-hydroxybenzoic acid sodium salt, 4-Amino-salicylic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C7H6NNaO3 · 2H2O
CAS Number:
Molecular Weight:
211.15
NACRES:
NA.22
PubChem Substance ID:
UNSPSC Code:
41116107
EC Number:
205-091-2
MDL number:
Assay:
≥97.0% (T)
Form:
powder
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InChI key

GMUQJDAYXZXBOT-UHFFFAOYSA-M

InChI

1S/C7H7NO3.Na.2H2O/c8-4-1-2-5(7(10)11)6(9)3-4;;;/h1-3,9H,8H2,(H,10,11);;2*1H2/q;+1;;/p-1

SMILES string

O.O.[Na+].Nc1ccc(c(O)c1)C([O-])=O

assay

≥97.0% (T)

form

powder

reaction suitability

reaction type: solution phase peptide synthesis

technique(s)

ligand binding assay: suitable

color

white to faintly beige

application(s)

peptide synthesis

Quality Level

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pictograms

Exclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves


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Sumit Chakraborty et al.
Science (New York, N.Y.), 339(6115), 88-91 (2012-11-03)
Folate biosynthesis is an established anti-infective target, and the antifolate para-aminosalicylic acid (PAS) was one of the first anti-infectives introduced into clinical practice on the basis of target-based drug discovery. Fifty years later, PAS continues to be used to treat
Cezary Chojnacki et al.
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 31(182), 92-96 (2011-09-23)
In order to maintain ulcerative colitis (UC) in remission, chronic use of aminosalicylates is recommended. All patients have a fear of the recurrence of symptoms, which makes their mental state and quality of life worse. Because of this a number
Amanda S Fivian-Hughes et al.
Microbiology (Reading, England), 158(Pt 2), 308-318 (2011-10-29)
Thymidylate synthase (TS) enzymes catalyse the biosynthesis of deoxythymidine monophosphate (dTMP or thymidylate), and so are important for DNA replication and repair. Two different types of TS proteins have been described (ThyA and ThyX), which have different enzymic mechanisms and
A C Liwa et al.
Journal of tropical pediatrics, 59(2), 90-94 (2012-11-24)
There are no paediatric data regarding slow-release para-aminosalicylic acid (PAS). We studied PAS plasma concentrations in 10 children receiving a single 150 mg/kg dose daily or 75 mg/kg twice daily and 12 adults receiving 4 g twice daily. Blood specimens
Lan Hong et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(10), 1904-1909 (2011-07-20)
para-aminosalicylic acid (PAS; 4-amino-2-hydroxybenzoic acid), an antituberculosis drug in use since the 1950s, has recently been suggested to be an effective agent for treatment of manganese-induced parkinsonian disorders. However, the neuropharmacokinetics of PAS and its metabolite N-acetyl-para-aminosalicylic acid (AcPAS; N-acetyl-4-amino-2-hydroxybenzoic

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