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16730

2-Bromo-2-chloro-1,1,1-trifluoroethane

≥99.0% (GC)

Synonym(s):

Halothane

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About This Item

Linear Formula:
BrCH(Cl)CF3
CAS Number:
151-67-7
Molecular Weight:
197.38
EC Number:
205-796-5
UNSPSC Code:
12352202
PubChem Substance ID:
329751365
Beilstein/REAXYS Number:
1736947
MDL number:
MFCD00009602
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vapor pressure

4.5 psi ( 20 °C)

assay

≥99.0% (GC)

refractive index

n20/D 1.369

bp

50.2 °C (lit.)

density

1.872 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

FC(F)(F)C(Cl)Br

InChI

1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

InChI key

BCQZXOMGPXTTIC-UHFFFAOYSA-N

Gene Information

human ... ATP5D(513), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GLRA1(2741), GLRB(2743), GRIA1(2890), KCNK10(54207), KCNK18(338567), KCNK2(3776), KCNK3(3777), KCNK9(51305), KCNN4(3783)

Biochem/physiol Actions

2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
Inhalation anesthetic.

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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Leigh D Plant et al.
Science signaling, 5(251), ra84-ra84 (2012-11-22)
The standing outward K(+) current (IKso) governs the response of cerebellar granule neurons to natural and medicinal stimuli including volatile anesthetics. We showed that SUMOylation silenced half of IKso at the surface of cerebellar granule neurons because the underlying channels
Jason T Moore et al.
Current biology : CB, 22(21), 2008-2016 (2012-10-30)
Despite seventeen decades of continuous clinical use, the neuronal mechanisms through which volatile anesthetics act to produce unconsciousness remain obscure. One emerging possibility is that anesthetics exert their hypnotic effects by hijacking endogenous arousal circuits. A key sleep-promoting component of
T Russell et al.
Anaesthesia, 67(9), 1021-1024 (2012-06-28)
We present the case of a 20-year-old woman who developed rhabdomyolysis, disseminated intravascular coagulopathy and multi-organ failure induced by ecstasy. Following initial improvement, she developed delayed rhabdomyolysis then haloperidol-induced neuroleptic malignant syndrome, which was treated with a total of 50
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Global Trade Item Number

SKUGTIN
CDS008204-250MG04061828977062