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Merck
CN

16730

2-Bromo-2-chloro-1,1,1-trifluoroethane

≥99.0% (GC)

Synonym(s):

Halothane

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About This Item

Linear Formula:
BrCH(Cl)CF3
CAS Number:
151-67-7
Molecular Weight:
197.38
EC Number:
205-796-5
UNSPSC Code:
12352202
PubChem Substance ID:
329751365
Beilstein/REAXYS Number:
1736947
MDL number:
MFCD00009602

Key Documents

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InChI key

BCQZXOMGPXTTIC-UHFFFAOYSA-N

InChI

1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H

SMILES string

FC(F)(F)C(Cl)Br

vapor pressure

4.5 psi ( 20 °C)

assay

≥99.0% (GC)

Gene Information

human ... ATP5D(513), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRD(2563), GABRE(2564), GABRG1(2565), GABRG2(2566), GABRG3(2567), GABRP(2568), GABRQ(55879), GLRA1(2741), GLRB(2743), GRIA1(2890), KCNK10(54207), KCNK18(338567), KCNK2(3776), KCNK3(3777), KCNK9(51305), KCNN4(3783)

bp

50.2 °C (lit.)

density

1.872 g/mL at 25 °C (lit.)

storage temp.

2-8°C

Biochem/physiol Actions

2-Bromo-2-chloro-1,1,1-trifluoroethane is an inhalation anesthetic. In an effect believed to be independent of anesthesia, halothane inhibits the synthesis of 5-hydroxytryptamine in brain tissue, probably at the tryptophan hydroxylase step.
Inhalation anesthetic.

signalword

Danger

Hazard Classifications

Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves

Regulatory Information

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William R Proctor et al.
Hepatology (Baltimore, Md.), 57(5), 2026-2036 (2012-12-15)
Drug-induced liver injury (DILI) is a major health issue, as it remains difficult to predict which new drugs will cause injury and who will be susceptible to this disease. This is due in part to the lack of animal models
Shinya Endo et al.
Toxicology, 319, 75-84 (2014-03-07)
MicroRNAs (miRNA) form a class of small non-coding RNA molecules that negatively regulate gene expression. Most cellular pathways are modulated by miRNAs. However, the pathophysiological role of miRNAs during drug-induced liver injury (DILI) remains largely unknown. In this study, the
Hilmi Orhan et al.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 18(1), 73-81 (2012-11-10)
To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane. Urine and blood samples were collected from patient groups. Excretion of
Barbara W Brandom et al.
Anesthesia and analgesia, 116(5), 1078-1086 (2013-04-06)
Mutations in the ryanodine receptor type 1 gene (RYR1) that encodes the skeletal muscle-specific intracellular calcium (Ca(2+)) release channel are a cause of malignant hyperthermia (MH). In this study, we examined RYR1 mutations in a large number of North American
Albert Quintana et al.
PloS one, 7(8), e42904-e42904 (2012-08-23)
Anesthetics are in routine use, yet the mechanisms underlying their function are incompletely understood. Studies in vitro demonstrate that both GABA(A) and NMDA receptors are modulated by anesthetics, but whole animal models have not supported the role of these receptors
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