932191
SPhos ChemBeads
solid
Sustainability features
Synonym(s):
2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl, S Phos, SPhos
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About This Item
Empirical Formula (Hill Notation):
C26H35O2P
CAS Number:
Molecular Weight:
410.53
MDL number:
UNSPSC Code:
12352128
NACRES:
NA.22
Product Name
SPhos ChemBeads,
Quality Segment
product line
ChemBeads
form
solid
reaction suitability
reagent type: catalyst
reaction type: Cross Couplings
sustainability
Sustainability features
SMILES string
P(C4CCCCC4)(C3CCCCC3)c1c(cccc1)c2c(cccc2OC)OC
InChI
1S/C26H35O2P/c1-27-23-17-11-18-24(28-2)26(23)22-16-9-10-19-25(22)29(20-12-5-3-6-13-20)21-14-7-4-8-15-21/h9-11,16-21H,3-8,12-15H2,1-2H3
InChI key
VNFWTIYUKDMAOP-UHFFFAOYSA-N
General description
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SPhos [2-Dicyclohexylphosphino-2′,6′-dimethoxybiphenyl] is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.
Application
SPhos may be used as a ligand in the following processes:
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
Learn more about ChemBeads products
Product is also available as neat ligand (638072)
- Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between Boc-protected aminomethyltrifluoroborate and aryl chlorides or hetaryl chlorides to form the corresponding aminomethylarenes.
- Palladium catalyzed Suzuki-Miyaura cross-coupling reaction between 4-methyl-substituted piperidinylzinc reagent and different aryl or heteroaryl iodides to form various substituted piperidines.
- Intramolecular Suzuki-Miyaura coupling to form the 18-membered macrocyclic ring during the multi-step synthesis of riccardin C.
Highly universal ligand for Suzuki-Miyaura coupling; aryl chlorides, hindered biaryls, heterobiaryls.
ChemBeads are chemical coated glass beads. ChemBeads offer improved flowability and chemical uniformity perfect for automated solid dispensing and high-throughput experimentation. The method of creating ChemBeads uses no other chemicals or surfactants allowing the user to accurately dispense sub-milligram amounts of chemical.
Learn more about ChemBeads products
Product is also available as neat ligand (638072)
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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