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Merck
CN

L4509

Sodium dodecyl sulfate

greener alternative

ReagentPlus®, ≥98.5% (GC)

Synonym(s):

SDS, Sodium lauryl sulfate, Dodecyl sodium sulfate, Dodecyl sulfate sodium salt, Lauryl sulfate sodium salt

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About This Item

Linear Formula:
CH3(CH2)11OSO3Na
CAS Number:
151-21-3
Molecular Weight:
288.38
NACRES:
NA.21
PubChem Substance ID:
24896370
eCl@ss:
39093306
UNSPSC Code:
12161900
EC Number:
205-788-1
MDL number:
MFCD00036175
Beilstein/REAXYS Number:
3599286

Key Documents

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biological source

synthetic

Quality Level

200

description

anionic

product line

ReagentPlus®

assay

≥98.5% (GC)

form

powder

mol wt

micellar avg mol wt 18,000

greener alternative product characteristics

Catalysis
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sustainability

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aggregation number

62

impurities

<2.0% water (Karl Fischer)

CMC

7-10 mM (20-25°C)

mp

204-207 °C (lit.)

transition temp

cloud point >100 °C

solubility

water: soluble

density

0.425 g/cm3

cation traces

Na: 7.0-9.0%

HLB

40

greener alternative category

Aligned

SMILES string

[Na+].CCCCCCCCCCCCOS([O-])(=O)=O

InChI

1S/C12H26O4S.Na/c1-2-3-4-5-6-7-8-9-10-11-12-16-17(13,14)15;/h2-12H2,1H3,(H,13,14,15);/q;+1/p-1

InChI key

DBMJMQXJHONAFJ-UHFFFAOYSA-M

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General description

Sodium dodecyl sulfate (SDS), or sodium lauryl sulfate, is widely recognized as an anionic surfactant within the organosulfate class of organic compounds. Its effectiveness as a detergent spans both ionic and anionic conditions. SDS plays a critical role as a protein denaturant, facilitating the solubilization and denaturation of proteins in procedures like protein extraction and SDS-PAGE. Its significance in the electrophoretic separation of proteins and lipids establishes its indispensability for the examination of these molecules in diverse biological experiments. In conclusion, Sodium dodecyl sulfate proves to be an indispensable element in the exploration of biological molecules within the realms of biochemical and cell biology research.
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Application

Sodium dodecyl sulphate (SDS) has been used:
  • in the characterization of Enterobacteriaceae strain based on sensitivity to selective compounds
  • to treat human skin in vitro and in vivo to evaluate the role of nuclear localization of 27-kDa heat shock protein (HSP27) in potential skin irritation
  • in the decellularization of porcine heart valve tissue
  • to treat sperm for in vitro induction of sperm decondensation

Anionic detergent

Biochem/physiol Actions

Sodium dodecyl sulphate (SDS) helps to quickly disrupt the biological membranes. It is usually used as one of the major constituent of several reagents, that are used to purify nucleic acids. SDS can block the activity of RNase and deoxyribonuclease (DNase).

Features and Benefits

  • Suitable for Cell Biology and Biochemical Research
  • High purity chemical suitable for multiple research applications

Other Notes

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Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

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Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Flam. Sol. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

4.1B - Flammable solid hazardous materials

flash_point_f

338.0 °F

flash_point_c

170 °C

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
0000543627
0000491828
0000541306
0000536483
0000509840

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A rapid and reliable alternative to ISO 21528-1: 2004 for detection of Enterobacteriaceae
Joosten H, et al.
International Journal of Food Microbiology, 125(3), 344-346 (2008)
Resilient ribonucleases
RNA Methodologies: A Laboratory Guide for Isolation and Characterization, 32-45 (1993)
Utility of light scatter in the morphological analysis of sperm
Zucker RM, et al.
Cytometry, 39-47 (1992)
Sub-Micellar Concentration of Sodium Dodecyl Sulphate Prevents Thermal Denaturation Induced Aggregation of Plant Lectin, Jacalin
Lavanya V, et al
The Protein Journal, 36(1), 17-27 (2017)
Minimally immunogenic decellularized porcine valve provides in situ recellularization as a stentless bioprosthetic valve.
Iwai S, et al.
Journal of Artificial Organs : The Official Journal of the Japanese Society for Artificial Organs, 10(1), 29-35 (2007)
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Global Trade Item Number

SKUGTIN
L4509-100G04061835546060
L4509-1KG04061835546084
L4509-25G04061833957561
L4509-10G04061835546077
L4509-500G04061835546107
L4509-250G04061835546091

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