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B3916

Boldine

analytical standard

Synonym(s):

2,9-Dihydroxy-1,10-dimethoxyaporphine

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About This Item

Empirical Formula (Hill Notation):
C19H21NO4
CAS Number:
476-70-0
Molecular Weight:
327.37
UNSPSC Code:
41116107
NACRES:
NA.24
PubChem Substance ID:
329773223
EC Number:
207-509-9
Beilstein/REAXYS Number:
94036
MDL number:
MFCD00135040
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biological source

plant (Peumus boldus molina)

Quality Level

100

grade

analytical standard

assay

≥98% (TLC)

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

impurities

≤1% isopropanol

mp

157-164  °C

solubility

ethanol: 50 mg/mL

application(s)

food and beverages
forensics and toxicology
veterinary

format

neat

storage temp.

room temp

SMILES string

COc1cc-2c(CC3N(C)CCc4cc(O)c(OC)c-2c34)cc1O

InChI

1S/C19H21NO4/c1-20-5-4-10-7-15(22)19(24-3)18-12-9-16(23-2)14(21)8-11(12)6-13(20)17(10)18/h7-9,13,21-22H,4-6H2,1-3H3/t13-/m0/s1

InChI key

LZJRNLRASBVRRX-ZDUSSCGKSA-N

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General description

Boldine is an aporphine alkaloid isolated from Boldo tree and other plant species. It is a free radical scavenger with anti-inflammatory activity while exhibiting other pharmacological effects such as antidiabetic, antiplatelet aggregation, antipyretic, antinociceptive, antiatherogenic, hepatoprotective and endothelium-protective activity.

Application

Boldine may be used as an analytical reference standard for the quantification of the analyte in biological samples and pharmaceutical preparations using chromatography techniques.
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL3487
BCBX5558
SLBB0164V

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J Fernández et al.
Phytotherapy research : PTR, 23(7), 1024-1027 (2009-01-16)
Peumus boldus Molina (Monimiaceae), commonly referred to as 'boldo', is used in traditional Chilean medicine to treat hepatic and gastrointestinal diseases. Its leaves are rich in antioxidant compounds, principally alkaloids and flavonoids. This study evaluates the protective effect of a
J Hung et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 59(13), 3177-3183 (2003-10-30)
In this work we present spectroscopic study of Boldine (aporphine alkaloid) that possesses important biological activities, in particular, in interaction with the promastigotes of Leishmania mexicana. The results show the applicability of autofluorescence of this drug to determinate the possible
C I Cámara et al.
Talanta, 83(2), 623-630 (2010-11-30)
The quantitative determination of boldine alkaloid in boldo leaf extracts by employing cyclic voltammetry, at a liquid/liquid interface as well as the validation of this methodology against the reference method, high performance liquid chromatography (HPLC), are reported in the present
N Santanam et al.
Atherosclerosis, 173(2), 203-210 (2004-04-06)
A corollary to the oxidation hypothesis of atherosclerosis is that the consumption of antioxidants is beneficial. However, the literature is divided in support of this conclusion. In this study, Boldine, an alkaloid of Peumus boldus and reduced form of RU486
Development of an HPLC fluorescence method for determination of boldine in plasma, bile and urine of rats and identification of its major metabolites by LC?MS/MS
Hroch M, et al.
Journal of Chromatography A, 936, 48-56 (2013)
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Global Trade Item Number

SKUGTIN
B3916-5G04061833429082
B3916-1G04061833429068

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